{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:53:39Z","timestamp":1791420819580,"version":"4.3.3"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Primary intrathoracic liposarcoma is extremely rare, and most published series lack genetic analyses. The aim of our study is to better understand the clinicopathologic and genetic features of these rare lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Forty-three primary intrathoracic liposarcomas were identified and most cases were analyzed by systematic genetic studies, including fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH), whole-exome sequencing (WES), and Sanger sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This series included 27 males and 16 females (ratios, 1.68:1) aged 24-73 years (median, 53 years). Tumors mainly occurred in the mediastinum (n=23, 53.5%), followed by pleural cavity (n=16, 37.2%) and lung (n=4, 9.3%). The study included 21 well-differentiated liposarcomas (WDLs), 19 dedifferentiated liposarcomas (DDLs), 2 myxoid pleomorphic liposarcomas (MPLs) and 1 pleomorphic liposarcoma (PL), without identification of myxoid liposarcoma. FISH analysis identified <jats:italic>MDM2<\/jats:italic> amplification in 17 of 18 WDLs (94.4%) and all DDLs (16\/16, 100.0%). The <jats:italic>MDM2<\/jats:italic>-nonamplified WDL was <jats:italic>CDK4<\/jats:italic>-nonamplified but <jats:italic>FRS2<\/jats:italic>-amplified. WES and Sanger sequencing found somatic <jats:italic>TP53<\/jats:italic> mutation in the 2 MPLs. Follow-up information was available for 33 of 38 cases (86.8%). Thirteen patients (39.4%) showed no evidence of disease, 10 patients (30.3%) were alive with disease, and 8 patients (24.2%) died of disease. Fourteen cases developed recurrence and 1 with metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>WDL\/DDL was the overwhelming subtype in this location, followed by MPL and PL. Analysis of the <jats:italic>FRS2<\/jats:italic> gene, in combination with <jats:italic>MDM2<\/jats:italic> and other genes of 12q13-15, may more precisely characterize WDL\/DDLs. MPL is the most fatal subtype of this site. Further studies are needed to explore the role of <jats:italic>TP53<\/jats:italic> in the pathogenesis of MPL.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.949962","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T07:50:52Z","timestamp":1660722652000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Primary intrathoracic liposarcomas: A clinicopathologic and molecular study of 43 cases in one of the largest medical centers of China"],"prefix":"10.3389","volume":"12","author":[{"given":"You","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"B1","article-title":"Atypical lipomatous tumour\/well-differentiated liposarcoma","volume-title":"WHO classification of tumours editorial board ed. world health organization classification of soft tissue and bone tumours","author":"Sbaraglia","year":"2020"},{"key":"B2","first-page":"39","article-title":"Dedifferentiated liposarcoma","volume-title":"WHO classification of tumours editorial board ed. world health organization classification of soft tissue and bone tumours","author":"Dei Tos","year":"2020"},{"key":"B3","article-title":"Myxoid liposarcoma","volume-title":"WHO classification of tumours editorial board ed. world health organization classification of soft tissue and bone tumours","author":"Thway","year":"2020"},{"key":"B4","article-title":"Pleomorphic liposarcoma","volume-title":"WHO classification of tumours editorial board ed. world health organization classification of soft tissue and bone tumours","author":"Pedeutour","year":"2020"},{"key":"B5","article-title":"Myxoid pleomorphic liposarcoma","volume-title":"WHO classification of tumours editorial board ed. world health organization classification of soft tissue and bone tumours","author":"Alaggio","year":"2020"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197912000-00004","article-title":"Liposarcoma: a study of 55 cases with a reassessment of its classification","volume":"3","author":"Evans","year":"1979","journal-title":"Am J Surg Pathol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5223(19)33575-5","article-title":"Lipoma and liposarcoma of the mediastinum: A report of 14 tumors including one lipoma of the thymus","volume":"47","author":"Cicciarelli","year":"1964","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199507000-00006","article-title":"Liposarcoma of the anterior mediastinum and thymus. 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