{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T23:16:49Z","timestamp":1783207009278,"version":"3.54.6"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The study aims to assess the incidence of short-term patient-reported postoperative gastrointestinal symptoms (PGISs) after gastric cancer surgery and explore the relative risk factors for the symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with radical gastrectomy were included for this retrospective and observational study. Symptoms extracted from the MD Anderson Symptom Inventory Gastrointestinal Cancer Module (MDASI-GI) were collected in postdischarge week (PDW) 1 and postoperative month (POM) 1. The distributing states of symptoms were analyzed in PDW1 and POM1. Logistic regression models were used to identify risk factors for PGISs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 356 patients with complete interviews, 156 (43.8%) patients reported abdominal distention in PDW1, which was significantly higher than patients in POM1 [103 (28.9%), <jats:italic>p<\/jats:italic> &amp;lt; 0.001]. Pain (15.2% vs. 9.8%), dysphagia (5.6% vs. 7.0%), diarrhea (3.7% vs. 3.4%), and vomiting (2.5% vs. 2.8%) had no significant differences between PDW1 and POM1. Logistic models found that risk factors for PGISs were total gastrectomy [odds ratio (OR): 1.948; 95% CI: 1.097\u20133.459; <jats:italic>p<\/jats:italic> = 0.023] and disturbed sleep (OR: 3.116; 95% CI: 1.831\u20135.303; <jats:italic>p<\/jats:italic> &amp;lt; 0.001) in PDW1 and female gender (OR: 1.726; 95% CI: 1.071\u20132.782; <jats:italic>p<\/jats:italic> = 0.025), total gastrectomy (OR: 1.729; 95% CI: 1.055\u20132.834; <jats:italic>p<\/jats:italic> = 0.030), and disturbed sleep (OR: 3.533; 95% CI: 1.757\u20137.106; <jats:italic>p<\/jats:italic> &amp;lt; 0.001) in POM1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The main symptom after gastric cancer surgery was abdominal distention. The relative risk factors for gastrointestinal symptoms after gastric cancer surgery were total gastrectomy and disturbed sleep. Timely symptom intervention may improve the quality of life of postgastrectomy patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.951485","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T09:49:55Z","timestamp":1663148995000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Patient-reported gastrointestinal symptoms following surgery for gastric cancer and the relative risk factors"],"prefix":"10.3389","volume":"12","author":[{"given":"Rui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuomeng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries]","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-043535","article-title":"Comparison of short-term outcomes and quality of life in totally laparoscopic distal gastrectomy and totally robotic distal gastrectomy for clinical stage I-III gastric cancer: study protocol for a multi-institutional randomised clinical trial","volume":"11","author":"Cui","year":"2021","journal-title":"BMJ Open"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.6133\/apjcn.202009_29(3).0004","article-title":"Does early postoperative enteral ecoimmunonutrition enhance intestinal function in gastric cancer","volume":"29","author":"Xu","year":"2020","journal-title":"Asia Pac J Clin Nutr"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4256347","article-title":"Short-term efficacy and quality of life of gastric cancer patients undergoing radical gastrectomy assisted by external vision","volume":"2021","author":"Zheng","year":"2021","journal-title":"Comput Math Methods Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn.441530-20210728-00301","article-title":"Shifting paradigm toward minimally invasive gastrectomy for gastric cancer\u2013china's contribution","volume":"24","author":"Li","year":"2021","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-021-01391-z","article-title":"Status of minimally invasive gastrectomy: Current advancements: robotic surgery and intraoperative imaging for gastric cancer]","volume":"92","author":"Berlth","year":"2021","journal-title":"Chirurg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2020.1270","article-title":"Development and validation of a symptom-focused quality of life questionnaire (KOQUSS-40) for gastric cancer patients after gastrectomy","volume":"53","author":"Eom","year":"2021","journal-title":"Cancer Res Treat"},{"key":"B8","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12885-020-6518-z","article-title":"GC-PROM: validation of a patient-reported outcomes measure for Chinese patients with gastric cancer","volume":"20","author":"Hu","year":"2020","journal-title":"BMC Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.10.002","article-title":"What does it really mean to \"recover\" from an operation","volume":"155","author":"Lee","year":"2014","journal-title":"Surgery"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002415","article-title":"How do we value postoperative recovery?: a systematic review of the measurement properties of patient-reported outcomes after abdominal surgery","volume":"267","author":"Fiore","year":"2018","journal-title":"Ann Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1477-7525-4-79","article-title":"Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance","volume":"4","year":"2006","journal-title":"Health Qual Life Outcomes"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2021.101727","article-title":"Impact of gastric cancer treatment on quality of life of patients","author":"Sch\u00fctte","year":"2021","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2020.02.005","article-title":"Quality of life after curative resection for gastric cancer: Survey metrics and implications of surgical technique","volume":"251","author":"Hu","year":"2020","journal-title":"J Surg Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1188\/12.ONF.157-165","article-title":"Gastrointestinal symptom representation in cancer symptom clusters: a synthesis of the literature","volume":"39","author":"Cherwin","year":"2012","journal-title":"Oncol Nurs Forum"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-017-0779-5","article-title":"The 8th edition of the American joint committee on cancer tumor-node-metastasis staging system for gastric cancer is superior to the 7th edition: results from a Chinese monoinstitutional study of 1663 patients","volume":"21","author":"Ji","year":"2018","journal-title":"Gastric Cancer"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24920","article-title":"Validation and application of a module of the m. d. Anderson symptom inventory for measuring multiple symptoms in patients with gastrointestinal cancer (the MDASI-GI)","volume":"116","author":"Wang","year":"2010","journal-title":"Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"197","DOI":"10.21037\/jgo-21-904","article-title":"Serum biomarkers predict adjuvant chemotherapy-associated symptom clusters in radical resected colorectal cancer patients","volume":"13","author":"Li","year":"2022","journal-title":"J Gastrointest Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1671-0274.2016.03.029","article-title":"Research advance in causes of postoperative gastrointestinal dysfunction","volume":"19","author":"Tan","year":"2016","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2021.08.065","article-title":"Management strategies of postoperative gastrointestinal tract dysfunction:a review of 210 cases","volume":"45","author":"Wang","year":"2022","journal-title":"Asian J Surg"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-3046","article-title":"Systematic review and meta-analysis of the effect of transcutaneous electrical acupoint stimulation on gastrointestinal function after laparoscopic surgery","volume":"10","author":"Zhang","year":"2021","journal-title":"Ann Palliat Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15020","article-title":"Dexamethasone on postoperative gastrointestinal motility: A placebo-controlled, double-blinded, randomized controlled trial","volume":"35","author":"Chen","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2016.16.4.230","article-title":"Postoperative quality of life after total gastrectomy compared with partial gastrectomy: Longitudinal evaluation by European organization for research and treatment of cancer-OG25 and STO22","volume":"16","author":"Lee","year":"2016","journal-title":"J Gastric Cancer"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2020.99.5.275","article-title":"The pattern of postoperative quality of life following minimally invasive gastrectomy for gastric cancer: a prospective cohort from Korean multicenter robotic gastrectomy trial","volume":"99","author":"Choi","year":"2020","journal-title":"Ann Surg Treat Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/J.JPAINSYMMAN.2010.10.266","article-title":"Symptom clusters in advanced cancer","volume":"42","author":"Ana","year":"2011","journal-title":"J Pain Symptom Manage"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.11.024","article-title":"General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the unites states","volume":"107","author":"Nolte","year":"2019","journal-title":"Eur J Cancer"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.03.025","article-title":"Anxiety and depression after cancer diagnosis: prevalence rates by cancer type, gender, and age","volume":"141","author":"Linden","year":"2012","journal-title":"J Affect Disord"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.36740\/WLek202202112","article-title":"Gender features of depressive and anxious manifestations of the lung cancer patients","volume":"75","author":"Belov","year":"2022","journal-title":"Wiad Lek"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S47790","article-title":"Sleeping well with cancer: a systematic review of cognitive behavioral therapy for insomnia in cancer patients","volume":"10","author":"Garland","year":"2014","journal-title":"Neuropsychiatr Dis Treat"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2015.16.11.4705","article-title":"Short sleep duration and its correlates among cancer survivors in Korea: the Korea national health and nutrition examination surveys","volume":"16","author":"Yoon","year":"2015","journal-title":"Asian Pac J Cancer Prev"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33372","article-title":"Quality of life among survivors of adolescent and young adult cancer in Canada: A young adults with cancer in their prime (YACPRIME) study","volume":"127","author":"Schulte","year":"2021","journal-title":"Cancer"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5524","article-title":"Effect of a technology-supported physical activity intervention on health-related quality of life, sleep, and processes of behavior change in cancer survivors: A randomized controlled trial","volume":"29","author":"Rastogi","year":"2020","journal-title":"Psychooncology"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2020.04.14","article-title":"Effectiveness of a comprehensive post-operative health education program in improving quality of life after gastric cancer surgery","volume":"9","author":"Gao","year":"2020","journal-title":"Ann Palliat Med"},{"key":"B33","article-title":"Effect of traditional Chinese medicine nursing on postoperative patients with gastric cancer and its impact on quality of life","volume":"13","author":"Zhang","year":"2021","journal-title":"Am J Transl Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2018.11.007","article-title":"Minimally invasive gastric cancer surgery","volume":"28","author":"Costantino","year":"2019","journal-title":"Surg Oncol Clin N Am"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.951485\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T09:50:02Z","timestamp":1663149002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.951485\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,14]]},"references-count":34,"alternative-id":["10.3389\/fonc.2022.951485"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2022.951485","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,14]]},"article-number":"951485"}}