{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:21:37Z","timestamp":1783948897952,"version":"3.55.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Quantitative contrast-enhanced ultrasonography parameters are affected by various factors. We evaluated corrected quantitative contrast enhanced ultrasonography in differentiating benign adnexal tumors from malignant tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with adnexal masses who underwent conventional and contrast-enhanced ultrasonography were included. Contrast-enhanced ultrasonography parameters such as base intensity, arrival time, peak intensity, time to peak intensity, ascending slope, and descending slope were measured. Corrected (time to peak intensity \u2212 arrival time) <jats:sub>mass\/<\/jats:sub>(time to peak intensity \u2212 arrival time) <jats:sub>uterus<\/jats:sub> and (peak intensity \u2212 base intensity) <jats:sub>mass\/<\/jats:sub>(peak intensity \u2212 base intensity) <jats:sub>uterus<\/jats:sub> were calculated. Lesions were confirmed by pathologic examination of surgical specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 31 patients with 35 adnexal lesions including 20 (57.10%) benign and 15 (42.90%) malignant lesions. The corrected contrast-enhanced ultrasonography quantitative parameters in lesions were statistically different between malignant and benign groups (<jats:italic>P<\/jats:italic>&amp;lt;0.05). The optimal cut-off value for (time to peak intensity \u2212 arrival time) <jats:sub>mass<\/jats:sub>\/(time to peak intensity \u2212 arrival time) <jats:sub>uterus<\/jats:sub>, ascending slope, and (peak intensity \u2212 base intensity) <jats:sub>mass<\/jats:sub>\/(peak intensity \u2212 base intensity) <jats:sub>uterus<\/jats:sub>, and descending slope for differentiating malignant adnexal masses from benign tumors were 1.05 (area under curve: 0.93,<jats:italic>\u00a0P<\/jats:italic>&amp;lt;0.05), 1.11 (area under curve: 0.83,\u00a0<jats:italic>P<\/jats:italic>&amp;lt;0.05), 0.82 (area under curve: 0.73,\u00a0<jats:italic>P<\/jats:italic>&amp;lt;0.05), and \u22120.27 (area under curve: 0.66,\u00a0<jats:italic>P<\/jats:italic>=0.16), with sensitivity and specificity of 93.33% and 85.00%, 86.67% and 75.00%, 86.67% and 60.00%, and 54.55% and 66.67%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Corrected contrast-enhanced ultrasonography parameters provide practical differential diagnosis value of adnexal lesions with high reliability for sonologists.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.968759","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T11:58:33Z","timestamp":1666267113000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Contrast-enhanced ultrasonography for differential diagnosis of adnexal 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