{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:58:46Z","timestamp":1783832326921,"version":"3.55.0"},"reference-count":173,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Glioma is the most common malignant intracranial tumor and exhibits diffuse metastasis and a high recurrence rate. The invasive property of glioma results from cell detachment. Anoikis is a special form of apoptosis that is activated upon cell detachment. Resistance to anoikis has proven to be a protumor factor. Therefore, it is suggested that anoikis resistance commonly occurs in glioma and promotes diffuse invasion. Several factors, such as integrin, E-cadherin, EGFR, IGFR, Trk, TGF-\u03b2, the Hippo pathway, NF-\u03baB, eEF-2 kinase, MOB2, hypoxia, acidosis, ROS, Hsp and protective autophagy, have been shown to induce anoikis resistance in glioma. In our present review, we aim to summarize the underlying mechanism of resistance and the therapeutic potential of these molecules.<\/jats:p>","DOI":"10.3389\/fonc.2022.976557","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T06:42:58Z","timestamp":1660545778000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Anoikis resistance in diffuse glioma: The potential therapeutic targets in the future"],"prefix":"10.3389","volume":"12","author":[{"given":"Zhengyang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyou","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houshi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjia","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwen","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqing","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.33800","article-title":"The miR-26a\/AP-2\u03b1\/Nanog signaling axis mediates stem cell self-renewal and temozolomide resistance in glioma","volume":"9","author":"Huang","year":"2019","journal-title":"Theranostics"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.41498","article-title":"ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma","volume":"10","author":"Tong","year":"2020","journal-title":"Theranostics"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2012.10.009","article-title":"Genetics of adult glioma","volume":"205","author":"Goodenberger","year":"2012","journal-title":"Cancer Genet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.12.003","article-title":"Immunotherapy for malignant glioma: Current status and future directions","volume":"41","author":"Wang","year":"2020","journal-title":"Trends Pharmacol Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41556-019-0443-x","article-title":"p120-catenin-dependent collective brain infiltration by glioma cell networks","volume":"22","author":"Gritsenko","year":"2020","journal-title":"Nat Cell Biol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.023820","article-title":"The extracellular matrix at a glance","volume":"123","author":"Frantz","year":"2010","journal-title":"J Cell Sci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"996","DOI":"10.7150\/thno.51646","article-title":"The 14-3-3\u03c3 protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1\/2 signaling pathway","volume":"11","author":"Song","year":"2021","journal-title":"Theranostics"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.7150\/thno.46001","article-title":"Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis","volume":"10","author":"Ye","year":"2020","journal-title":"Theranostics"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44025","article-title":"STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"B11","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41575-018-0021-x","article-title":"Mitochondrial function - gatekeeper of intestinal epithelial cell homeostasis","volume":"15","author":"Rath","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial membrane permeabilization in cell death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol Rev"},{"key":"B13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1136\/svn-2021-001396","article-title":"Inhibition of the postsynaptic density protein 95 on the protective effect of ang-(1-7)-Mas on cerebral ischaemia injury","volume":"84","author":"Zhao","year":"2022","journal-title":"Stroke Vasc Neurol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11010-010-0709-x","article-title":"Role of bcl-2 family proteins and caspases in the regulation of apoptosis","volume":"351","author":"Ola","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.06.026","article-title":"Anoikis molecular pathways and its role in cancer progression","volume":"1833","author":"Paoli","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071553","article-title":"The fas signaling pathway: more than a paradigm","volume":"296","author":"Wajant","year":"2002","journal-title":"Science"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/svn-2017-000109","article-title":"BICAO-induced ischaemia caused depressive-like behaviours and caspase-8\/-9-dependent brain regional neural cell apoptosis in mice","volume":"3","author":"Liu","year":"2018","journal-title":"Stroke Vasc Neurol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"188357","DOI":"10.1016\/j.bbcan.2020.188357","article-title":"Caspase-8: The double-edged sword","volume":"1873","author":"Mandal","year":"2020","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nri3834","article-title":"Regulation of tumour necrosis factor signalling: live or let die","volume":"15","author":"Brenner","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4315","article-title":"beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts","volume":"65","author":"Goel","year":"2005","journal-title":"Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00137.x","article-title":"Expression of integrin alphavbeta3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature","volume":"18","author":"Schnell","year":"2008","journal-title":"Brain Pathol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10555-008-9165-4","article-title":"Signal transduction by focal adhesion kinase in cancer","volume":"28","author":"Zhao","year":"2009","journal-title":"Cancer Metastasis Rev"},{"key":"B24","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/nrc3792","article-title":"FAK in cancer: mechanistic findings and clinical applications","volume":"14","author":"Sulzmaier","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2018.4583","article-title":"An RGD small-molecule integrin antagonist induces detachment-mediated anoikis in glioma cancer stem cells","volume":"53","author":"Paolillo","year":"2018","journal-title":"Int J Oncol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3892\/ijo.2012.1708","article-title":"A small-molecule RGD-integrin antagonist inhibits cell adhesion, cell migration and induces anoikis in glioblastoma cells","volume":"42","author":"Russo","year":"2013","journal-title":"Int J Oncol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.52","article-title":"Role of MMP-2 in the regulation of IL-6\/Stat3 survival signaling via interaction with alpha5beta1 integrin in glioma","volume":"32","author":"Kesanakurti","year":"2013","journal-title":"Oncogene"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.131","article-title":"Integrin alpha5beta1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma","volume":"23","author":"Renner","year":"2016","journal-title":"Cell Death Differ"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e445","DOI":"10.1038\/cddis.2012.182","article-title":"Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma","volume":"3","author":"Kesanakurti","year":"2012","journal-title":"Cell Death Dis"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws351","article-title":"Integrin control of the transforming growth factor-beta pathway in glioblastoma","volume":"136","author":"Roth","year":"2013","journal-title":"Brain"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e1012","DOI":"10.1038\/cddis.2013.543","article-title":"Integrin inhibition promotes atypical anoikis in glioma cells","volume":"5","author":"Silginer","year":"2014","journal-title":"Cell Death Dis"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.387","article-title":"The aryl hydrocarbon receptor links integrin signaling to the TGF-\u03b2 pathway","volume":"35","author":"Silginer","year":"2016","journal-title":"Oncogene"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080920","article-title":"Expression of integrin alpha6beta1 enhances tumorigenesis in glioma cells","volume":"175","author":"Delamarre","year":"2009","journal-title":"Am J Pathol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.12.050","article-title":"Anoikis resistance conferred by tenascin-c-derived peptide TNIIIA2 and its disruption by integrin inactivation","volume":"536","author":"Fujita","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"B35","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s00223-013-9733-7","article-title":"Cadherin-mediated cell-cell adhesion and signaling in the skeleton","volume":"94","author":"Marie","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201706013","article-title":"Src- and confinement-dependent FAK activation causes e-cadherin relaxation and beta-catenin activity","volume":"217","author":"Gayrard","year":"2018","journal-title":"J Cell Biol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/1476-4598-10-101","article-title":"Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer","volume":"10","author":"Minde","year":"2011","journal-title":"Mol Cancer"},{"key":"B38","doi-asserted-by":"publisher","first-page":"567305","DOI":"10.1155\/2011\/567305","article-title":"E-cadherin\/beta-catenin complex and the epithelial barrier","volume":"2011","author":"Tian","year":"2011","journal-title":"J BioMed Biotechnol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105331200","article-title":"Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein","volume":"277","author":"Weng","year":"2002","journal-title":"J Biol Chem"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.146.4.855","article-title":"Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest","volume":"146","author":"Orford","year":"1999","journal-title":"J Cell Biol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.178","article-title":"\u03b2-catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids","volume":"34","author":"Condello","year":"2015","journal-title":"Oncogene"},{"key":"B42","article-title":"Aldehyde dehydrogenase 1A1 circumscribes high invasive glioma cells and predicts poor prognosis","volume":"5","author":"Xu","year":"2015","journal-title":"Am J Cancer Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-019-00460-0","article-title":"Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the \u03b2-catenin\/ID2 pathway","volume":"42","author":"Wang","year":"2019","journal-title":"Cell Oncol (Dordr)"},{"key":"B44","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.semcancer.2012.02.013","article-title":"EMT as the ultimate survival mechanism of cancer cells","volume":"22","author":"Tiwari","year":"2012","journal-title":"Semin Cancer Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41419-018-1293-3","article-title":"PIM kinases mediate resistance of glioblastoma cells to TRAIL by a p62\/SQSTM1-dependent mechanism","volume":"10","author":"Serrano-Saenz","year":"2019","journal-title":"Cell Death Dis"},{"key":"B46","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41416-020-01177-w","article-title":"TRAIL receptor-induced features of epithelial-to-mesenchymal transition increase tumour phenotypic heterogeneity: potential cell survival mechanisms","volume":"124","author":"Peyre","year":"2021","journal-title":"Br J Cancer"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422504112","article-title":"Discovery and functional characterization of a neomorphic PTEN mutation","volume":"112","author":"Costa","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208427","article-title":"Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB\/Akt activation, induces apoptosis, and delays tumor growth","volume":"24","author":"Edwards","year":"2005","journal-title":"Oncogene"},{"key":"B49","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1136\/svn-2020-000422","article-title":"Associations of blood biomarkers with glomerular filtration rate in patients with TIA and stroke: population-based study","volume":"6","author":"Kelly","year":"2021","journal-title":"Stroke Vasc Neurol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00322-0","article-title":"Antitumour immunity regulated by aberrant ERBB family signalling","volume":"21","author":"Kumagai","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.cell.2007.11.013","article-title":"SnapShot: EGFR signaling pathway","volume":"131","author":"Yarden","year":"2007","journal-title":"Cell"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.04.003","article-title":"Inhibition of DHHC20-mediated EGFR palmitoylation creates a dependence on EGFR signaling","volume":"62","author":"Runkle","year":"2016","journal-title":"Mol Cell"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.034","article-title":"The somatic genomic landscape of glioblastoma","volume":"155","author":"Brennan","year":"2013","journal-title":"Cell"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1026","article-title":"Integrins and EGFR coordinately regulate the pro-apoptotic protein bim to prevent anoikis","volume":"5","author":"Reginato","year":"2003","journal-title":"Nat Cell Biol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.209","article-title":"Anoikis evasion in inflammatory breast cancer cells is mediated by bim-EL sequestration","volume":"22","author":"Buchheit","year":"2015","journal-title":"Cell Death Differ"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.05.009","article-title":"Interleukin-8 upregulates integrin beta3 expression and promotes estrogen receptor-negative breast cancer cell invasion by activating the PI3K\/Akt\/NF-kappaB pathway","volume":"364","author":"Shao","year":"2015","journal-title":"Cancer Lett"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0317","article-title":"Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3","volume":"65","author":"Schlessinger","year":"2005","journal-title":"Cancer Res"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.430","article-title":"TMEM43\/LUMA is a key signaling component mediating EGFR-induced NF-kappaB activation and tumor progression","volume":"36","author":"Jiang","year":"2017","journal-title":"Oncogene"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0250","article-title":"IGF system in sarcomas: a crucial pathway with many unknowns to exploit for therapy","volume":"61","author":"Mancarella","year":"2018","journal-title":"J Mol Endocrinol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.89","article-title":"Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis","volume":"30","author":"Burnier","year":"2011","journal-title":"Oncogene"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202471","article-title":"Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion","volume":"18","author":"Valentinis","year":"1999","journal-title":"Oncogene"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0350","article-title":"Parallel phosphatidylinositol-3 kinase and p42\/44 mitogen-activated protein kinase signaling pathways subserve the mitogenic and antiapoptotic actions of insulin-like growth factor I in osteoblastic cells","volume":"144","author":"Grey","year":"2003","journal-title":"Endocrinology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12943-015-0482-2","article-title":"Insulin-like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase\/Akt pathway","volume":"15","author":"Luey","year":"2016","journal-title":"Mol Cancer"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.376","article-title":"A phosphatase-independent gain-of-function mutation in PTEN triggers aberrant cell growth in astrocytes through an autocrine IGF-1 loop","volume":"33","author":"Fernandez","year":"2014","journal-title":"Oncogene"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/path.4734","article-title":"Glioma progression is mediated by an addiction to aberrant IGFBP2 expression and can be blocked using anti-IGFBP2 strategies","volume":"239","author":"Phillips","year":"2016","journal-title":"J Pathol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.2.413-424.2006","article-title":"RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth","volume":"26","author":"Zhang","year":"2006","journal-title":"Mol Cell Biol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1038\/s41467-019-11614-x","article-title":"A STAT3-based gene signature stratifies glioma patients for targeted therapy","volume":"10","author":"Tan","year":"2019","journal-title":"Nat Commun"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161629","article-title":"Trk receptors: roles in neuronal signal transduction","volume":"72","author":"Huang","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"B69","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1146\/annurev.neuro.26.041002.131421","article-title":"Selectivity in neurotrophin signaling: theme and variations","volume":"26","author":"Segal","year":"2003","journal-title":"Annu Rev Neurosci"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1460","article-title":"Extracellular domain of neurotrophin receptor trkB: disulfide structure, n-glycosylation sites, and ligand binding","volume":"322","author":"Haniu","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000869200","article-title":"The atypical protein kinase c-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor","volume":"276","author":"Wooten","year":"2001","journal-title":"J Biol Chem"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90066-M","article-title":"Nerve growth factor mediates signal transduction through trk homodimer receptors","volume":"9","author":"Jing","year":"1992","journal-title":"Neuron"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0651","article-title":"On trk\u2013the TrkB signal transduction pathway is an increasingly important target in cancer biology","volume":"15","author":"Thiele","year":"2009","journal-title":"Clin Cancer Res"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0121","article-title":"Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis","volume":"67","author":"Geiger","year":"2007","journal-title":"Cancer Res"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.4161\/cc.24759","article-title":"TrkB is responsible for EMT transition in malignant pleural effusions derived cultures from adenocarcinoma of the lung","volume":"12","author":"Ricci","year":"2013","journal-title":"Cell Cycle"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05739-2","article-title":"Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma","volume":"47","author":"Pinheiro","year":"2020","journal-title":"Mol Biol Rep"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9329","article-title":"MNX1 reduces sensitivity to anoikis by activating TrkB in human glioma cells","volume":"18","author":"Jiang","year":"2018","journal-title":"Mol Med Rep"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.96","article-title":"Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis","volume":"30","author":"Smit","year":"2011","journal-title":"Oncogene"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.7150\/thno.57701","article-title":"TGF-\u03b2 loaded exosome enhances ischemic wound healing in vitro and in vivo","volume":"11","author":"Shi","year":"2021","journal-title":"Theranostics"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3434","article-title":"TGFbeta signalling in context","volume":"13","author":"Massague","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"a022129","DOI":"10.1101\/cshperspect.a022129","article-title":"Non-smad signaling pathways of the TGF-beta family","volume":"9","author":"Zhang","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.11.005","article-title":"TGF-beta as a therapeutic target in high grade gliomas - promises and challenges","volume":"85","author":"Joseph","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0499","article-title":"DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-beta-driven epithelial-mesenchymal transition","volume":"3","author":"Chen","year":"2013","journal-title":"Cancer Discovery"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.024","article-title":"EMT: Matter of life or death","volume":"164","author":"Gupta","year":"2016","journal-title":"Cell"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12632","article-title":"Sirtuin 6 promotes transforming growth factor-beta1\/H2O2\/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence","volume":"106","author":"Feng","year":"2015","journal-title":"Cancer Sci"},{"key":"B86","doi-asserted-by":"publisher","first-page":"104973","DOI":"10.1016\/j.tiv.2020.104973","article-title":"Ophiopogonin d suppresses TGF-\u03b21-mediated metastatic behavior of MDA-MB-231 breast carcinoma cells via regulating ITGB1\/FAK\/Src\/AKT\/\u03b2-catenin\/MMP-9 signaling axis","volume":"69","author":"Zhu","year":"2020","journal-title":"Toxicol In Vitro"},{"key":"B87","doi-asserted-by":"publisher","first-page":"8993","DOI":"10.7150\/thno.62302","article-title":"Activation of hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2221","article-title":"Filling out the hippo pathway","volume":"8","author":"Saucedo","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B89","doi-asserted-by":"publisher","first-page":":321\u201337.e10","DOI":"10.1016\/j.cell.2018.03.035","article-title":"Oncogenic signaling pathways in the cancer genome atlas","volume":"173","author":"Sanchez-Vega","year":"2018","journal-title":"Cell"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201900162","article-title":"YAP\/TAZ: Drivers of tumor growth, metastasis, and resistance to therapy","volume":"42","author":"Thompson","year":"2020","journal-title":"Bioessays"},{"key":"B91","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1101\/gad.173435.111","article-title":"Cell detachment activates the hippo pathway via cytoskeleton reorganization to induce anoikis","volume":"26","author":"Zhao","year":"2012","journal-title":"Genes Dev"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-0018","article-title":"YAP\/TAZ transcriptional coactivators create therapeutic vulnerability to verteporfin in EGFR-mutant glioblastoma","volume":"27","author":"Vigneswaran","year":"2021","journal-title":"Clin Cancer Res"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1002\/path.5133","article-title":"Fatal correlation between YAP1 expression and glioma aggressiveness: clinical and molecular evidence","volume":"246","author":"Guichet","year":"2018","journal-title":"J Pathol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1726608","article-title":"YAP regulates neural progenitor cell number via the TEA domain transcription factor","volume":"22","author":"Cao","year":"2008","journal-title":"Genes Dev"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0301-5","article-title":"Transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity","volume":"37","author":"Yu","year":"2018","journal-title":"Oncogene"},{"key":"B96","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/neuonc\/noab244","article-title":"Anti-invasive efficacy and survival benefit of the YAP-TEAD inhibitor verteporfin in preclinical glioblastoma models","volume":"24","author":"Barrette","year":"2022","journal-title":"Neuro-oncology"},{"key":"B97","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1136\/svn-2016-000046","article-title":"Geraniin inhibits TNF-\u03b1-induced impairments of osteogenesis through NF-\u03baB and p38 MAPK signalling pathways in bone marrow stem cells","volume":"2","author":"Lu","year":"2017","journal-title":"Stroke Vasc Neurol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.7150\/thno.58322","article-title":"Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-\u03baB signaling to trigger pyroptosis in breast cancer","volume":"11","author":"Tan","year":"2021","journal-title":"Theranostics"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81698-0","article-title":"Structure of an IkappaBalpha\/NF-kappaB complex","volume":"95","author":"Jacobs","year":"1998","journal-title":"Cell"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512178200","article-title":"Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1","volume":"281","author":"Toruner","year":"2006","journal-title":"J Biol Chem"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-013-0847-1","article-title":"Regulation of anoikis by deleted in breast cancer-1 (DBC1) through NF-kappaB","volume":"18","author":"Park","year":"2013","journal-title":"Apoptosis"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0034-2","article-title":"RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells","volume":"20","author":"Hawk","year":"2018","journal-title":"Nat Cell Biol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.20","article-title":"Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis","volume":"4","author":"Kamarajugadda","year":"2013","journal-title":"Cell Death Dis"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr224","article-title":"Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion","volume":"103","author":"Edwards","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab095","article-title":"Cannabidiol converts NF-\u03baB into a tumor suppressor in glioblastoma with defined antioxidative properties","volume":"23","author":"Volmar","year":"2021","journal-title":"Neuro-oncology"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/334170a0","article-title":"Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation","volume":"334","author":"Ryazanov","year":"1988","journal-title":"Nature"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00035","article-title":"Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons","volume":"8","author":"Heise","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-013-0927-2","article-title":"Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells","volume":"19","author":"Ashour","year":"2014","journal-title":"Apoptosis an Int J On Programmed Cell Death"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1554","article-title":"Elongation factor-2 kinase regulates autophagy in human glioblastoma cells","volume":"66","author":"Wu","year":"2006","journal-title":"Cancer Res"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.213","article-title":"Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells","volume":"32","author":"Zhang","year":"2011","journal-title":"Acta Pharmacol Sin"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.09.038","article-title":"Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates bcl-xL expression","volume":"414","author":"Zhang","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081345","article-title":"Inhibition of elongation factor-2 kinase augments the antitumor activity of temozolomide against glioma","volume":"8","author":"Liu","year":"2013","journal-title":"PloS One"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00150-10","article-title":"Differential NDR\/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases","volume":"30","author":"Kohler","year":"2010","journal-title":"Mol Cell Biol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/s41419-020-2381-8","article-title":"MOB2 suppresses GBM cell migration and invasion via regulation of FAK\/Akt and cAMP\/PKA signaling","volume":"11","author":"Jiang","year":"2020","journal-title":"Cell Death Dis"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-7472-0","article-title":"The magic of the hypoxia-signaling cascade","volume":"65","author":"Benizri","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002339107","article-title":"Regulation of human metabolism by hypoxia-inducible factor","volume":"107","author":"Formenti","year":"2010","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-04-0353","article-title":"Hypoxia suppression of bim and bmf blocks anoikis and luminal clearing during mammary morphogenesis","volume":"21","author":"Whelan","year":"2010","journal-title":"Mol Biol Cell"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.426999","article-title":"The oncogene HER2\/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance","volume":"288","author":"Whelan","year":"2013","journal-title":"J Biol Chem"},{"key":"B120","doi-asserted-by":"publisher","first-page":"11127","DOI":"10.1038\/s41598-017-11769-x","article-title":"Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines","volume":"7","author":"Baba","year":"2017","journal-title":"Sci Rep"},{"key":"B121","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bbrc.2019.05.115","article-title":"Loss of cell-matrix contact increases hypoxia-inducible factor-dependent transcriptional activity in glioma cells","volume":"515","author":"Maurer","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"B122","doi-asserted-by":"publisher","first-page":":454","DOI":"10.1073\/pnas.1721650115","article-title":"TGF\u03b22-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells","volume":"11","author":"Corbet","year":"2020","journal-title":"Nat Commun"},{"key":"B123","doi-asserted-by":"publisher","first-page":"8340926","DOI":"10.1155\/2019\/8340926","article-title":"Anoikis resistance as a further trait of acidic-adapted melanoma cells","volume":"2019","author":"Peppicelli","year":"2019","journal-title":"J Oncol"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00020","article-title":"Extracellular proton concentrations impacts LN229 glioblastoma tumor cell fate via differential modulation of surface lipids","volume":"7","author":"John","year":"2017","journal-title":"Front Oncol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.716406","article-title":"Reactive oxygen species: Not omnipresent but important in many locations","volume":"9","author":"Herb","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2018-000205","article-title":"Lipid peroxidation and ferroptosis after intracerebral haemorrhage","volume":"4","author":"Wan","year":"2019","journal-title":"Stroke Vasc Neurol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"E10","DOI":"10.3171\/foc.2006.21.6.1","article-title":"Selective enhancement of cellular oxidative stress by chloroquine: implications for the treatment of glioblastoma multiforme","volume":"21","author":"Toler","year":"2006","journal-title":"Neurosurg Focus"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1106-1213","article-title":"ROS as a tumour suppressor","volume":"8","author":"Ramsey","year":"2006","journal-title":"Nat Cell Biol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5040","article-title":"Redox molecular machines involved in tumor progression","volume":"19","author":"Parri","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.77","article-title":"Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for src and EGFR-mediated pro-survival signals","volume":"28","author":"Giannoni","year":"2009","journal-title":"Oncogene"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8717","article-title":"Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"B133","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1038\/s41467-021-24108-6","article-title":"Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance","volume":"12","author":"Huang","year":"2021","journal-title":"Nat Commun"},{"key":"B134","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11060-007-9347-x","article-title":"PAX6 increases glioma cell susceptibility to detachment and oxidative stress","volume":"84","author":"Chang","year":"2007","journal-title":"J Neurooncol 84"},{"key":"B135","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s13046-019-1173-4","article-title":"Celastrol mediates autophagy and apoptosis via the ROS\/JNK and Akt\/mTOR signaling pathways in glioma cells","volume":"38","author":"Liu","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"B136","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.phrs.2017.01.014","article-title":"Dihydroartemisin inhibits glioma invasiveness via a ROS to P53 to \u03b2-catenin signaling","volume":"119","author":"Que","year":"2017","journal-title":"Pharmacol Res"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.7150\/thno.49876","article-title":"Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70","volume":"11","author":"Hyun","year":"2021","journal-title":"Theranostics"},{"key":"B138","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0006-2952(99)00299-3","article-title":"Heat shock factors and the control of the stress response","volume":"59","author":"Santoro","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020402)41:7<1098::AID-ANIE1098>3.0.CO;2-9","article-title":"Molecular chaperones\u2013cellular machines for protein folding","volume":"41","author":"Walter","year":"2002","journal-title":"Angew Chem Int Ed Engl"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos326","article-title":"PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma","volume":"15","author":"Alam","year":"2013","journal-title":"Neuro-oncology"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-16-0262","article-title":"Interference with the HSF1\/HSP70\/BAG3 pathway primes glioma cells to matrix detachment and BH3 mimetic-induced apoptosis","volume":"16","author":"Antonietti","year":"2017","journal-title":"Mol Cancer Ther"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: crosstalk between autophagy and apoptosis","volume":"8","author":"Maiuri","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.11.027","article-title":"The interconnections between autophagy and integrin-mediated cell adhesion","volume":"429","author":"Vlahakis","year":"2017","journal-title":"J Mol Biol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s41419-021-04494-x","article-title":"ATF4\/CEMIP\/PKCalpha promotes anoikis resistance by enhancing protective autophagy in prostate cancer cells","volume":"13","author":"Yu","year":"2022","journal-title":"Cell Death Dis"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721650115","article-title":"MDA-9\/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells","volume":"115","author":"Talukdar","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0052","article-title":"Central nervous system cancers, version 3.2020, NCCN clinical practice guidelines in oncology","volume":"18","author":"Nabors","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"key":"B147","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/cdd.2014.97","article-title":"Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, erk signaling-dependent cells","volume":"22","author":"Kyjacova","year":"2015","journal-title":"Cell Death Differ"},{"key":"B148","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12885-017-3193-9","article-title":"The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures","volume":"17","author":"Narayan","year":"2017","journal-title":"BMC Cancer"},{"key":"B149","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s00018-022-04420-0","article-title":"CD146 increases stemness and aggressiveness in glioblastoma and activates YAP signaling","volume":"79","author":"Liang","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094471","article-title":"Cellular model of malignant transformation of primary human astrocytes induced by Deadhesion\/Readhesion cycles","volume":"23","author":"da","year":"2022","journal-title":"Int J Mol Sci 23"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not058","article-title":"Phase II study of cilengitide in the treatment of refractory or relapsed high-grade gliomas in children: a report from the children's oncology group","volume":"15","author":"MacDonald","year":"2013","journal-title":"Neuro-oncology"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27585","article-title":"A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306)","volume":"118","author":"Nabors","year":"2012","journal-title":"Cancer"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e328362edc5","article-title":"Cilengitide targets pediatric glioma and neuroblastoma cells through cell detachment and anoikis induction","volume":"24","author":"Leblond","year":"2013","journal-title":"Anticancer Drugs"},{"key":"B154","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.tranon.2014.02.016","article-title":"Integrin inhibitor suppresses bevacizumab-induced glioma invasion","volume":"7","author":"Ishida","year":"2014","journal-title":"Transl Oncol"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.110","article-title":"Phase II trial of gefitinib in recurrent glioblastoma","volume":"22","author":"Rich","year":"2004","journal-title":"J Clin Oncol"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.01.070","article-title":"Phase II evaluation of gefitinib in patients with newly diagnosed grade 4 astrocytoma: Mayo\/North central cancer treatment group study N0074","volume":"80","author":"Uhm","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq199","article-title":"A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the pediatric brain tumor consortium","volume":"13","author":"Pollack","year":"2011","journal-title":"Neuro-oncology"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.10.008","article-title":"RTOG 0211: a phase 1\/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients","volume":"85","author":"Chakravarti","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-021-03763-1","article-title":"A phase I\/II study of bevacizumab, irinotecan and erlotinib in children with progressive diffuse intrinsic pontine glioma","volume":"153","author":"El-Khouly","year":"2021","journal-title":"J Neurooncol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1677","article-title":"InsR\/IGF1R pathway mediates resistance to EGFR inhibitors in glioblastoma","volume":"22","author":"Ma","year":"2016","journal-title":"Clin Cancer Res"},{"key":"B161","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1093\/neuonc\/noab274","article-title":"Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors","volume":"24","author":"Doz","year":"2021","journal-title":"Neuro Oncol"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq142","article-title":"Targeted therapy for high-grade glioma with the TGF-beta2 inhibitor trabedersen: results of a randomized and controlled phase IIb study","volume":"13","author":"Bogdahn","year":"2011","journal-title":"Neuro Oncol"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-020-00910-9","article-title":"Phase 1b\/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma","volume":"38","author":"Wick","year":"2020","journal-title":"Invest New Drugs"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now009","article-title":"A phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma","volume":"18","author":"Brandes","year":"2016","journal-title":"Neuro Oncol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"120100","DOI":"10.1016\/j.lfs.2021.120100","article-title":"Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells","volume":"287","author":"Momeny","year":"2021","journal-title":"Life Sci"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2013.38","article-title":"The integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus","volume":"20","author":"Fujii","year":"2013","journal-title":"Cancer Gene Ther"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1012-906c","article-title":"Clinical setbacks reduce IGF-1 inhibitors to cocktail mixers","volume":"30","author":"Allison","year":"2012","journal-title":"Nat Biotechnol"},{"key":"B168","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.drup.2019.04.002","article-title":"The TICking clock of EGFR therapy resistance in glioblastoma: Target independence or target compensation","volume":"43","author":"Saleem","year":"2019","journal-title":"Drug Resist Update"},{"key":"B169","doi-asserted-by":"publisher","first-page":":753","DOI":"10.3390\/ijms21030753","article-title":"NTRK fusions in central nervous system tumors: A rare, but worthy target","volume":"21","author":"Gambella","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28010038","article-title":"Canadian Consensus for biomarker testing and treatment of TRK fusion cancer in pediatric patients","volume":"28","author":"Perreault","year":"2021","journal-title":"Curr Oncol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13045-021-01053-x","article-title":"Novel therapies emerging in oncology to target the TGF-beta pathway","volume":"14","author":"Kim","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3358","article-title":"Individual patient-specific immunity against high-grade glioma after vaccination with autologous tumor derived peptides bound to the 96 KD chaperone protein","volume":"19","author":"Crane","year":"2013","journal-title":"Clin Cancer Res an Off J Am Assoc For Cancer Res"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.10.003","article-title":"Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment","volume":"273","author":"Jakubowicz-Gil","year":"2013","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.976557\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T06:43:04Z","timestamp":1660545784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.976557\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,15]]},"references-count":173,"alternative-id":["10.3389\/fonc.2022.976557"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2022.976557","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,15]]},"article-number":"976557"}}