{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:59:59Z","timestamp":1785531599236,"version":"3.56.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To retrospectively evaluate the efficacy and safety of local ablation treatment for adjacent pleural lung tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Sixty-two patients who underwent pulmonary nodule ablation at the Affiliated Cancer Hospital of Zhengzhou University were enrolled between January 2016 and December 2020. All patients were followed up with enhanced computed tomography or magnetic resonance imaging within 48\u00a0h after treatment and 2, 4, 6, 9, and 12 months after treatment. All patients were followed for at least 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 84 targeted tumors (62 patients) underwent 94 ablations. In the 12-month follow-up images, 69 of the 84 targeted tumors were completely ablated, 15 had incomplete ablation, and the 12-month incomplete ablation rate was 17.8% (15\/84). Of the 15 incompletely ablated tumors, six had partial responses, five had stable disease, and four had progressive disease. The most common adverse event was pneumothorax, with an incidence of 54.8% (34\/62). The second most common complication was pleural effusion, with an incidence rate of 41.9% (26\/62). The incidence of needle-tract bleeding was 21% (13\/62) and all patients were cured using hemostatic drugs. Serious complications were bronchopleural fistula in four patients (6.5%, 4\/62) and needle tract metastasis in one patient. Four cases of bronchopleural fistula were found in the early stages and were cured after symptomatic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Local ablation is effective for the treatment of adjacent pleural lung tumors, and its operation is safe and controllable.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.976777","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T11:04:06Z","timestamp":1661166246000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Local ablation of pulmonary malignancies abutting pleura: Evaluation of midterm local efficacy and safety"],"prefix":"10.3389","volume":"12","author":[{"given":"Hong-Tao","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Jun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Le","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3918045","DOI":"10.1155\/2022\/3918045","article-title":"Cancer burden in China during 1990-2019: Analysis of the global burden of disease","volume":"2022","author":"Zhang","year":"2022","journal-title":"BioMed Res Int"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.02.029","article-title":"Outcomes of sublobar resection versus lobectomy for stage I non-small cell lung cancer: A 13-year analysis","volume":"82","author":"El-Sherif","year":"2006","journal-title":"Ann Thorac surgery"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.11.013","article-title":"Stereotactic body radiation therapy for stage I non-small cell lung carcinomas: Moderate hypofractionation optimizes outcome","volume":"126","author":"Menoux","year":"2018","journal-title":"Lung Cancer"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11584-3","article-title":"Phase III study of sublobar resection (SR. versus stereotactic ablative radiotherapy (SAbR. @ in high-risk patients with stage I non-small cell lung cancer (NSCLC)","volume":"29","author":"Teke","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.11.042","article-title":"Stereotactic body radiation therapy for earlystage non-small-cell lung carcinoma: four-year results of a prospective phase II study","volume":"75","author":"Fakiris","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"B7","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1148\/radiol.11101643","article-title":"Microwave ablation therapy: Clinical utility in treatment of pulmonary metastases","volume":"261","author":"Vogl","year":"2011","journal-title":"Radiology"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_1040_19","article-title":"Effectiveness of radiofrequency ablation therapy for patients with unresected stage IA non-small cell lung cancer","volume":"16","author":"Li","year":"2020","journal-title":"J Cancer Res Ther"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020192558","article-title":"Percutaneous radiofrequency ablation is ready for prime time in the treatment of colorectal pulmonary metastases","volume":"294","author":"Gemmete","year":"2020","journal-title":"Radiology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-109010","article-title":"Thermal ablation of lung tumors: Focus on microwave ablation","volume":"189","author":"Vogl","year":"2017","journal-title":"Rofo"},{"key":"B11","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3892\/mco.2022.2495","article-title":"Microwave ablation vs. cryoablation for treatment of primary and metastatic pulmonary malignant tumors","volume":"16","author":"Li","year":"2022","journal-title":"Mol Clin Oncol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"5783","DOI":"10.3390\/jcm10245783","article-title":"Percutaneous image-guided ablation of lung tumors","volume":"10","author":"Alzubaidi","year":"2021","journal-title":"J Clin Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-21-1636","article-title":"A prospective trial of CT-guided percutaneous microwave ablation for lung tumors","volume":"14","author":"Reisenauer","year":"2022","journal-title":"J Thorac Dis"},{"key":"B14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3978\/j.issn.2304-3865.2015.05.06","article-title":"Chinese Society of thoracic and cardiovascular surgery lung cancer study group. expert consensus on image-guided radiofrequency ablation of pulmonary tumors\u20132015 edition","volume":"4","author":"Liu","year":"2015","journal-title":"Chin Clin Oncol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/icvts\/ivw089","article-title":"Long-term results of percutaneous radiofrequency ablation of pulmonary metastases: A single institution experience","volume":"23","author":"Fanucchi","year":"2016","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13419","article-title":"Image-guided percutaneous microwave ablation of early-stage non-small cell lung cancer","volume":"16","author":"Ni","year":"2020","journal-title":"Asia Pac J Clin Oncol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2014.13440","article-title":"CT-guided percutaneous cryoablation of central lung tumors","volume":"20","author":"Colak","year":"2014","journal-title":"Diagn Interv Radiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2020.1784472","article-title":"Complications after 100 sessions of cone-beam computed tomography-guided lung radiofrequency ablation: A single-center, retrospective experience","volume":"37","author":"Kim","year":"2020","journal-title":"Int J Hyperthermia"},{"key":"B19","article-title":"Radiofrequency ablation of lung metastasis not suitable for surgery: Experience in siriraj hospital","volume":"98","author":"Tongdee","year":"2015","journal-title":"J Med Assoc Thai"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2303021801","article-title":"Radiofrequency ablation: effect of surrounding tissue composition on coagulation necrosis in a canine tumor model","volume":"230","author":"Ahmed","year":"2004","journal-title":"Radiology"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2402050807","article-title":"Midterm local efficacy and survival after radiofrequency ablation of lung tumors with minimum follow-up of 1 year: prospective evaluation","volume":"240","author":"de Ba\u00e8re","year":"2006","journal-title":"Radiology"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.03.034","article-title":"Long-term results of CT-guided percutaneous radiofrequency ablation of inoperable patients with stage ia non-small cell lung cancer: A retrospective cohort study","volume":"53","author":"Huang","year":"2018","journal-title":"Int J Surg"},{"key":"B23","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1148\/radiol.11101643","article-title":"Microwave ablation therapy: Clinical utility in treatment of pulmonary metastases","volume":"261","author":"Vogl","year":"2011","journal-title":"Radiology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"494","DOI":"10.2214\/AJR.21.26551","article-title":"Comparison of percutaneous image-guided microwave ablation and cryoablation for sarcoma lung metastases: A 10-year experience","volume":"218","author":"Bourgouin","year":"2022","journal-title":"AJR Am J Roentgenol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4103\/0973-1075.173951","article-title":"Percutaneous image-guided radiofrequency ablation of tumors in inoperable patients - immediate complications and overall safety","volume":"22","author":"Sahay","year":"2016","journal-title":"Indian J Palliat Care"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2006.10.011","article-title":"Intractable pneumothorax due to bronchopleural fistula after radiofrequency ablation of lung tumors","volume":"18","author":"Sakurai","year":"2007","journal-title":"J Vasc Interv Radiol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/23975691","article-title":"Intractable bronchopleural fistula caused by radiofrequency ablation: Endoscopic bronchial occlusion with silicone embolic material","volume":"82","author":"Kodama","year":"2009","journal-title":"Br J Radiol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6.3955","article-title":"Bronchopleural fistulas: an overview of the problem with special focus on endoscopic management","volume":"128","author":"Lois","year":"2005","journal-title":"Chest"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-008-9489-z","article-title":"Delayed development of pneumothorax after pulmonary radiofrequency ablation","volume":"32","author":"Clasen","year":"2009","journal-title":"Cardiovasc Interv Radiol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2008.9.2.140","article-title":"Radiofrequency ablation using a monopolar wet electrode for the treatment of inoperable non-small cell lung cancer: a preliminary report","volume":"9","author":"Jin","year":"2008","journal-title":"Korean J Radiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1378\/chest.119.2.590","article-title":"AACP pneumothorax consensus group. management of spontaneous pneumothorax: An American college of chest physicians Delphi consensus statement","volume":"119","author":"Baumann","year":"2001","journal-title":"Chest"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13137","article-title":"Efficacy and safety of artificial pneumothorax with position adjustment for CT-guided percutaneous transthoracic microwave ablation of small subpleural lung tumors","volume":"10","author":"Jia","year":"2019","journal-title":"Thorac Cancer"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/13645706.2017.1287089","article-title":"Artificial pneumothorax: a safe and simple method to relieve pain during microwave ablation of subpleural lung malignancy","volume":"26","author":"Hou","year":"2017","journal-title":"Minim Invasive Ther Allied Technol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.976777\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T13:04:58Z","timestamp":1661259898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.976777\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,22]]},"references-count":33,"alternative-id":["10.3389\/fonc.2022.976777"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2022.976777","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,22]]},"article-number":"976777"}}