{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:44Z","timestamp":1753891844010,"version":"3.41.2"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Damage associated with lymphoma-associated hemophagocytic lymphohistiocytosis (LA-HLH) to the central nervous system (CNS) is not uncommon. However, the combination with brain damage resembling acute necrotizing encephalopathy (ANE) is rarely reported. Herein, we introduce the diagnosis and treatment of a case of ANE associated with LA-HLH in our hospital and review the relevant literature. After treatment, the child was discharged with only dysarthria and decreased sucking ability. The child is now discharged from the hospital for 6\u00a0months with regular follow-up. There were no disease recurrence signs. LA-HLH and ANE were related to cytokine storm. Therefore, early steroid application is essential for treating these diseases.<\/jats:p>","DOI":"10.3389\/fonc.2022.986957","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T06:54:15Z","timestamp":1667199255000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute necrotizing encephalopathy associated with lymphoma-associated hemophagocytic lymphohistiocytosis: A case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Wenqiang","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changchang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018894618","article-title":"Recommendations for the management of hemophagocytic lymphohistiocytosis in adults","volume":"133","author":"La Rosee","year":"2019","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"6859","DOI":"10.4081\/hr.2017.6859","article-title":"Hemophagocytic lymphohistiocytosis, an unclear nosologic entity: Case report of an adult man with rising of amylase and lipase and spinal cord infiltration","volume":"9","author":"Sangineto","year":"2017","journal-title":"Hematol Rep"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.07.012","article-title":"Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes","volume":"34","author":"Hoshino","year":"2012","journal-title":"Brain Dev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000058757.52327.17","article-title":"Acute necrotizing encephalopathy of childhood with radiographic progression over 10 hours","volume":"60","author":"Bassuk","year":"2003","journal-title":"Neurology"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.5.555","article-title":"Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions","volume":"58","author":"Mizuguchi","year":"1995","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2014.05.007","article-title":"A severity score for acute necrotizing encephalopathy","volume":"37","author":"Yamamoto","year":"2015","journal-title":"Brain Dev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14144","article-title":"Understanding the spectrum of haemophagocytic lymphohistiocytosis: Update on diagnostic challenges and therapeutic options","volume":"174","author":"Brisse","year":"2016","journal-title":"Br J Haematol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0802-RA","article-title":"Hemophagocytic lymphohistiocytosis","volume":"146","author":"Ponnatt","year":"2022","journal-title":"Arch Pathol Lab Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23405","article-title":"Neuroradiologic findings and follow-up with magnetic resonance imaging of the genetic forms of haemophagocytic lymphohistiocytosis with CNS involvement","volume":"58","author":"Rego","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-003-0894-9","article-title":"Imaging characteristics of hemophagocytic lymphohistiocytosis","volume":"33","author":"Fitzgerald","year":"2003","journal-title":"Pediatr Radiol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.08.030","article-title":"Acute necrotizing encephalopathy associated with hemophagocytic syndrome","volume":"34","author":"Akiyoshi","year":"2006","journal-title":"Pediatr Neurol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.04.054","article-title":"Severe cerebral involvement in adult-onset hemophagocytic lymphohistiocytosis","volume":"76","author":"Radmanesh","year":"2020","journal-title":"J Clin Neurosci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13052-016-0286-z","article-title":"Brain damage resembling acute necrotizing encephalopathy as a specific manifestation of haemophagocytic lymphohistiocytosis - 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