{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:32:06Z","timestamp":1787985126779,"version":"build-2784847793"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Castleman\u00b4s disease is an extremely rare heterogenous lymphoproliferative pathology with a mostly benign behavior. It is a localized or generalized lymph node enlargement of an unknown aetiology. Unicentric form is typically a slow-growing solitary mass occurring mostly in the mediastinum, abdominal cavity, retroperitoneum, pelvis and neck. Aetiology and pathogenesis of CD is probably diverse, varying in different types of this heterogeneous disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Authors present a review of this issue based on their extensive experience. The aim is to summarize the crucial factors in the management of diagnostics and a surgical treatment of the unicentric form of Castleman\u00b4s disease. One of the key issues in the unicentric form is precise preoperative diagnostics and thus choosing the right surgical treatment strategy. Authors highlight pitfalls of the diagnosis and surgical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All histological types such as a hyaline vascular type, plasmacytic type and a mixed type are presented as well as options of surgical and conservative treatment. Differential diagnosis and malignant potential is discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with Castleman\u00b4s disease should be treated in the high- volume centers, with a great experience in major surgical procedures as well as with preoperative imaging diagnostic techniques. Specialized pathologists and oncologists focusing on this issue are also absolutely necessary to avoid misdiagnosis. Only this complex approach can lead to excellent outcomes in patients with UCD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2023.1057683","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T13:06:37Z","timestamp":1675083997000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Unicentric form of Castleman\u00b4s disease, pitfalls of diagnosis and surgical treatment"],"prefix":"10.3389","volume":"13","author":[{"given":"Jiri","family":"Molacek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav","family":"Treska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Skalicky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Vodicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Ferda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Ferdova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Baxa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Mach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Jungova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Michal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195607\/08)9:4<822::AID-CNCR2820090430>3.0.CO;2-4","article-title":"Localized mediastinal lymph-node hyperplasia resembling thymoma","volume":"9","author":"Castleman","year":"1956","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.918444","article-title":"Unicentric castleman's disease: Laparoscopic approach of a para-duodenal retroperitoneal mass","volume":"21","author":"Sawaya","year":"2020","journal-title":"Am J Case Rep"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000931","article-title":"Overview of castleman disease","volume":"135","author":"Dispenzieri","year":"2020","journal-title":"Blood"},{"key":"B4","first-page":"3","article-title":"Castleman's disease. A review","volume":"11","author":"Roca","year":"2009","journal-title":"AIDS Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.hoc.2017.09.006","article-title":"Unicentric castleman disease","volume":"32","author":"Wong","year":"2018","journal-title":"Hematol Oncol Clin North Am"},{"key":"B6","doi-asserted-by":"publisher","first-page":"36","DOI":"10.5603\/ARM.2018.0008","article-title":"The role of surgical resection in unicentric castleman's disease: A systematic review","volume":"86","author":"Mitsos","year":"2018","journal-title":"Adv Respir Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15921","article-title":"Treatment and outcome of unicentric castleman disease: A retrospective analysis of 71 cases","volume":"186","author":"Boutboul","year":"2019","journal-title":"Br J Haematol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15019","article-title":"The full spectrum of castleman disease: 273 patients studied over 20 years","volume":"180","author":"Oksenhendler","year":"2018","journal-title":"Br J Haematol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003334","article-title":"International evidence-based consensus diagnostic and treatment guidelines for unicentric castleman disease","volume":"4","author":"van Rhee","year":"2020","journal-title":"Blood Adv"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.953145","article-title":"Use of a claims database to characterize and estimate the incidence rate for castleman disease","volume":"56","author":"Munshi","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.hoc.2017.09.001","article-title":"Epidemiology of castleman disease","volume":"32","author":"Simpson","year":"2018","journal-title":"Hematol Oncol Clin North Am"},{"key":"B12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1080\/13506129.2019.1641078","article-title":"Epidemiology of castleman disease associated with AA amyloidosis: Description of 2 new cases and literature review","volume":"26","author":"Fayand","year":"2019","journal-title":"Amyloid"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318249dcdc","article-title":"Surgery in castleman's disease: A systematic review of 404 published cases","volume":"255","author":"Talat","year":"2012","journal-title":"Ann Surg"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0075","article-title":"Castleman's disease: Systematic analysis of 416 patients from the literature","volume":"16","author":"Talat","year":"2011","journal-title":"Oncologist"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-017-0238-6","article-title":"Laparoscopic treatment of abdominal unicentric castleman's disease: A case report and literature review","volume":"17","author":"Bracale","year":"2017","journal-title":"BMC Surg"},{"key":"B16","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/ajh.23291","article-title":"The clinical spectrum of castleman\u00b4s disease","volume":"87","author":"Dispenzieri","year":"2012","journal-title":"Amer J Hematol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjx195","article-title":"Castleman's disease: A rare presentation in a retroperitoneal accessory spleen, treated with a minimally invasive robotic approach","volume":"2017","author":"Sbrana","year":"2017","journal-title":"J Surg Case Rep"},{"key":"B18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.hoc.2017.09.002","article-title":"Castleman disease pathogenesis","volume":"32","author":"Fajgenbaum","year":"2018","journal-title":"Hematol Oncol Clin North Am"},{"key":"B19","unstructured":""}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1057683\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T13:07:01Z","timestamp":1675084021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1057683\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":19,"alternative-id":["10.3389\/fonc.2023.1057683"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2023.1057683","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]},"article-number":"1057683"}}