{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:08:40Z","timestamp":1793088520743,"version":"4.5.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Accurate pathologic diagnosis and molecular classification of breast mass biopsy tissue is important for determining individualized therapy for (neo)adjuvant systemic therapies for invasive breast cancer. The CassiII rotational core biopsy system is a novel biopsy technique with a guide needle and a \u201cstick-freeze\u201d technology. The comprehensive assessments including the concordance rates of diagnosis and biomarker status between CassiII and core needle biopsy were evaluated in this study. Estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), and Ki67 were analyzed through immunohistochemistry. In total, 655 patients with breast cancer who underwent surgery after biopsy at Sir Run Run Shaw Hospital between January 2019 to December 2021 were evaluated. The concordance rates (CRs) of malignant surgical specimens with CassiII needle biopsy was significantly high compared with core needle biopsy. Moreover, CassiII needle biopsy had about 20% improvement in sensitivity and about 5% improvement in positive predictive value compared to Core needle biopsy. The characteristics including age and tumor size were identified the risk factors for pathological inconsistencies with core needle biopsies. However, CassiII needle biopsy was associated with tumor diameter only. The CRs of ER, PgR, HER2, and Ki67 using Cassi needle were 98.08% (kappa, 0.941; p&amp;lt;.001), 90.77% (kappa, 0.812; p&amp;lt;.001), 69.62% (kappa, 0.482; p&amp;lt;.001), and 86.92% (kappa, 0.552; p&amp;lt;.001), respectively. Post-biopsy complications with CassiII needle biopsy were also collected. The complications of CassiII needle biopsy including chest stuffiness, pain and subcutaneous ecchymosis are not rare. The underlying mechanism of subcutaneous congestion or hematoma after CassiII needle biopsy might be the larger needle diameter and the effect of temperature on coagulation function. In summary, CassiII needle biopsy is age-independent and has a better accuracy than CNB for distinguishing carcinoma <jats:italic>in situ<\/jats:italic> and invasive carcinoma.<\/jats:p>","DOI":"10.3389\/fonc.2023.1067246","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T10:51:27Z","timestamp":1695811887000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["A retrospective comparative study on the diagnostic efficacy and the complications: between CassiII rotational core biopsy and core needle biopsy"],"prefix":"10.3389","volume":"13","author":[{"given":"Shuduo","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misha","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA: A Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt303","article-title":"Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013","volume":"24","author":"Goldhirsch","year":"2013","journal-title":"Ann Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31891-8","article-title":"Breast cancer","volume":"389","author":"Harbeck","year":"2017","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-193008000-00002","article-title":"BIOPSY BY NEEDLE PUNCTURE AND ASPIRATION","volume":"92","author":"Martin","year":"1930","journal-title":"Ann Surg"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4741.2003.09301.x","article-title":"Core needle biopsy versus fine-needle aspiration biopsy: are there similar sampling and diagnostic issues","volume":"9","author":"Masood","year":"2003","journal-title":"Breast J"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21433","article-title":"Core needle biopsy versus fine needle aspiration biopsy in breast\u2014A historical perspective and opportunities in the modern era","volume":"39","author":"Nassar","year":"2011","journal-title":"Diagn Cytopathol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/dc.20189","article-title":"Obituary: \u201cAlas poor FNA of breast\u2014We knew thee well!\u201d","volume":"32","author":"Cobb","year":"2005","journal-title":"Diagn Cytopathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2001.0875","article-title":"Should fine needle aspiration cytology in breast assessment be abandoned","volume":"57","author":"Litherland","year":"2002","journal-title":"Clin Radiol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.10.025","article-title":"Impact of molecular subtypes classification concordance between preoperative core needle biopsy and surgical specimen on early breast cancer management: Single-institution experience and review of published literature","volume":"43","author":"Meattini","year":"2017","journal-title":"Eur J Surg Oncol (EJSO)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200410","article-title":"Diagnosis of breast lesions: fine-needle aspiration cytology or core needle biopsy? 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