{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:14:01Z","timestamp":1770902041933,"version":"3.50.1"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>We present a case of a woman with non-small-cell lung cancer (NSCLC) who experienced disease progression during treatment with the epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) osimertinib due to an unplanned pregnancy. Given the risk of tumor progression, the patient underwent an artificial abortion. However, disease deterioration occurred shortly after termination of the pregnancy, with severe chest pain, increased dyspnea, and pleural effusion. After positive rescue measures, including emergency thoracic drainage, thoracentesis, and oxygen uptake, her symptoms improved. Considering pregnancy as an immune escape physiological process, the patient continued treatment with osimertinib, and a partial response (PR) lasting 16 months was observed. Therefore, this case highlights the importance of being vigilant about the rapid development of the tumor after delivery in pregnant patients with EGFR-mutation lung cancer and taking preventive measures to cope with various emergencies.<\/jats:p>","DOI":"10.3389\/fonc.2023.1073938","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T07:18:02Z","timestamp":1697527082000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Termination of unplanned pregnancy led to rapid deterioration of non-small-cell lung cancer during osimertinib treatment"],"prefix":"10.3389","volume":"13","author":[{"given":"Qizhi","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kexun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32809","article-title":"Lung cancer incidence in young women vs. young men: A systematic analysis in 40 countries","volume":"147","author":"Fidler-Benaoudia","year":"2020","journal-title":"Int J Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1056\/NEJMoa1715907","article-title":"Higher lung cancer incidence in young women than young men in the United States","volume":"378","author":"Jemal","year":"2018","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.10.014","article-title":"Cancer and pregnancy: poena magna, not anymore","volume":"42","author":"Pentheroudakis","year":"2006","journal-title":"Eur J Cancer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.lungcan.2013.09.002","article-title":"Lung cancer in pregnancy: report of nine cases from an international collaborative study","volume":"82","author":"Boussios","year":"2013","journal-title":"Lung Cancer"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904554","article-title":"Screening for epidermal growth factor receptor mutations in lung cancer","volume":"361","author":"Rosell","year":"2009","journal-title":"N Engl J Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41571-022-00639-9","article-title":"Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management","volume":"19","author":"Cooper","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2015.12.004","article-title":"Lung cancer during pregnancy: A narrative review","volume":"7","author":"Mitrou","year":"2016","journal-title":"J Adv Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12967-019-1828-0","article-title":"The role of CEA, CYFRA21-1 and NSE in monitoring tumor response to Nivolumab in advanced non-small cell lung cancer (NSCLC) patients","volume":"17","author":"Dal Bello","year":"2019","journal-title":"J Transl Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"8850873","DOI":"10.1155\/2020\/8850873","article-title":"The combination of CA125 and NSE is useful for predicting liver metastasis of lung cancer","volume":"2020","author":"Wang","year":"2020","journal-title":"Dis Markers"},{"key":"B11","doi-asserted-by":"publisher","first-page":"9845123","DOI":"10.1155\/2018\/9845123","article-title":"Assessment of seven clinical tumor markers in diagnosis of non-small-cell lung cancer","volume":"2018","author":"Chen","year":"2018","journal-title":"Dis Markers"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2002-0279","article-title":"Coexistence of pregnancy and Malignancy","volume":"7","author":"Pavlidis","year":"2002","journal-title":"Oncologist"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00312-3","article-title":"Lung cancer","volume":"398","author":"Thai","year":"2021","journal-title":"Lancet"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.4.384","article-title":"Cancer in pregnancy: maternal and fetal implications","volume":"7","author":"Weisz","year":"2001","journal-title":"Hum Reprod Update"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-21-234","article-title":"Clinical features and intervention timing in patients with pregnancy-associated non-small-cell lung cancer","volume":"13","author":"Yang","year":"2021","journal-title":"J Thorac Dis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.lungcan.2021.09.001","article-title":"Use of tyrosine kinase inhibitors during pregnancy for oncogenic-driven advanced non-small cell lung carcinoma","volume":"161","author":"Boudy","year":"2021","journal-title":"Lung Cancer"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.12.010","article-title":"No cancer in cancers: evolutionary trade-off between successful viviparity and tumor escape from the adaptive immune system","volume":"66","author":"Hayakawa","year":"2006","journal-title":"Med Hypotheses"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.3251","article-title":"Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung","volume":"27","author":"Nose","year":"2009","journal-title":"J Clin Oncol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.09.210","article-title":"Growth factors, as biological macromolecules in bioactivity enhancing of electrospun wound dressings for diabetic wound healing: A review","volume":"193","author":"Zhang","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1872","article-title":"Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects","volume":"65","author":"Stabile","year":"2005","journal-title":"Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgaa064","article-title":"Interplay between estrogen and Stat3\/NF-\u03baB-driven immunomodulation in lung cancer","volume":"41","author":"Deng","year":"2020","journal-title":"Carcinogenesis"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1105-18","article-title":"Rapid progression of lung cancer following emergency caesarean section led to postpartum acute respiratory failure","volume":"58","author":"Watanabe","year":"2019","journal-title":"Intern Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/01.JTO.0000268680.33238.01","article-title":"Metastatic adenocarcinoma of the lung in a 27-year-old pregnant woman","volume":"2","author":"But Hadzic","year":"2007","journal-title":"J Thorac Oncol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-247530","article-title":"Unplanned pregnancy in an HIV positive woman undergoing alectinib treatment for metastatic non-small-cell lung carcinoma","volume":"15","author":"Carlier","year":"2022","journal-title":"BMJ Case Rep"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.02.005","article-title":"First case report of pregnancy on alectinib in a woman with metastatic ALK-rearranged lung cancer: A case report","volume":"16","author":"Scarfone","year":"2021","journal-title":"J Thorac Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1073938\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T07:18:04Z","timestamp":1697527084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1073938\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":25,"alternative-id":["10.3389\/fonc.2023.1073938"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2023.1073938","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]},"article-number":"1073938"}}