{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:58:14Z","timestamp":1773248294380,"version":"3.50.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Ovarian metastasis of breast cancer with pseudo-Meigs\u2019 syndrome (PMS) is extremely rare. Only four cases of PMS secondary to breast cancer with ovarian metastasis have been reported to date. In this report, we present the fifth case of PMS caused by ovarian metastasis of breast cancer. On the 2nd of July 2019, a 53-year-old woman presented to our hospital with complaints of abdominal distension, irregular vaginal bleeding, and chest distress. Color Doppler ultrasound examination revealed a mass approximately 109\u00d789 mm in size in the right adnexal area, accompanied by multiple uterine fibroids and a large amount of pelvic and peritoneal effusions. The patient had no common symptoms and showed no signs of breast cancer. The main manifestations were a right ovarian mass, massive hydrothorax, and ascites. Lab workup and imaging revealed raised CA125 (cancer antigen 125) levels and multiple bone metastases. At first the patient was misdiagnosed with ovarian carcinoma. After the rapid disappearance of oophorectomy hydrothorax and ascites, and decreased CA125 levels, from 1,831.8u\/ml to normal range. According to the pathology report, breast cancer was finally diagnosed. The patient underwent endocrine therapy (Fulvestrant) and azole treatment after oophorectomy. At the 40-month follow-up, the patient was still alive and doing well.<\/jats:p>","DOI":"10.3389\/fonc.2023.1091956","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T04:58:02Z","timestamp":1683521882000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pseudo-Meigs\u2019 syndrome secondary to breast cancer with ovarian metastasis: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiang-Ying","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Xuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2325\/jbcs.13.344","article-title":"Pseudo-meigs' syndrome caused by breast cancer metastasis to both ovaries","volume":"13","author":"Fujii","year":"2006","journal-title":"Breast Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-009-4187-2","article-title":"Pseudo-meigs' syndrome associated with breast cancer metastasis to both ovaries: report of a case","volume":"40","author":"Kawakubo","year":"2010","journal-title":"Surg Today"},{"key":"B3","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3892\/mco.2021.2297","article-title":"Ovarian metastasis from breast cancer mimicking a primary ovarian neoplasm: a case report","volume":"15","author":"Akizawa","year":"2021","journal-title":"Mol Clin Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2012.15.4.474","article-title":"A case of pseudo-meigs' syndrome associated with ovarian metastases from breast cancer","volume":"15","author":"Naito","year":"2012","journal-title":"J Breast Cancer"},{"key":"B5","article-title":"Benign pelvic tumors associated with ascites and pleural effusion","volume":"1","author":"Salmon","year":"1934","journal-title":"J Mount Sinai Hosp"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1177\/01410768870800042014","article-title":"Meigs' syndrome and pseudo-meigs' syndrome","volume":"80","author":"Flanagan","year":"1987","journal-title":"J R Soc Med"},{"key":"B7","article-title":"Pseudomeigs syndrome. associated with metastatic cancer of ovary","volume":"72","author":"Ryan","year":"1972","journal-title":"New York state J Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s40792-016-0209-7","article-title":"Pseudo-meigs' syndrome due to ovarian metastases from colon cancer: a case report and review of the literature","volume":"2","author":"Yamamoto","year":"2016","journal-title":"Surg Case Rep"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1016\/s0140-6736(16)32389-3","article-title":"Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (Falcon): an international, randomised, double-blind, phase 3 trial","volume":"388","author":"Robertson","year":"2016","journal-title":"Lancet"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1159\/000018893","article-title":"Pseudo-meigs' syndrome caused by secondary ovarian tumors from gastrointestinal cancer. a case report and review of the literature","volume":"17","author":"Nagakura","year":"2000","journal-title":"Digestive Surg"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5086","article-title":"Ovarian metastasis in endometrial carcinoma","volume":"70","author":"Takeshima","year":"1998","journal-title":"Gynecol Oncol"},{"key":"B12","article-title":"Ovarian metastases in breast carcinoma","volume":"95","author":"Horvath","year":"1977","journal-title":"Fortschr der Med"},{"key":"B13","article-title":"Management of ovarian metastasis from breast carcinoma: combined modality therapy with salvage surgery and chemoendocrine therapy","volume":"10","author":"Tabei","year":"1995","journal-title":"Jpn J Breast Cancer"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890815)64:4<892::aid-cncr2820640422>3.0.co;2-c","article-title":"Ovarian metastases of breast carcinoma. a clinicopathologic study of 59 cases","volume":"64","author":"Gagnon","year":"1989","journal-title":"Cancer"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(54)90258-6","article-title":"Fibroma of the ovary with ascites and hydrothorax; 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