{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:32:00Z","timestamp":1774467120096,"version":"3.50.1"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although laparoscopic hepatectomy has been widely used in the treatment of benign and malignant liver diseases, its applicability in intrahepatic cholangiocarcinoma (ICC) is controversial. We conducted a meta-analysis to compare the short-term and long-term outcomes of laparoscopic hepatectomy (Lap-ICC) and open hepatectomy (Open-ICC) in ICC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PubMed, Web of science, Cochrane Library, China National Knowledge Infrastructure and other databases were searched for the relevant literature. The research data were extracted according to the inclusion and exclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen studies, including 3975 ICC patients, were selected for the meta-analysis. Compared to Open-ICC, Lap-ICC had lower rates of lymph node dissection (OR=0.44, P=0.01) and metastasis (OR=0.58, P=0.03), along with less intraoperative bleeding (MD=-128.43 ml, P&amp;lt;0.01) lower blood transfusion rate (OR=0.43, P&amp;lt;0.01), shorter hospital stay (MD=-2.75 day, P&amp;lt;0.01), higher R0 resection rate (OR=1.60, P&amp;lt;0.01), and lower tumor recurrence rate (OR=0.67, P=0.01). However, there was no difference between the two groups in terms of operation time, number of lymph node dissection, incision margin distance, overall complications rate, severe complications rate, and the 1-, 3- and 5-year DFS and OS rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laparoscopic hepatectomy is partially superior to open hepatectomy in terms of less bleeding, shorter hospital stay and higher R0 resection rate, while the long-term efficacy of the two approaches is similar.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2023.1096714","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T07:32:45Z","timestamp":1677655965000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Laparoscopic or open liver resection for intrahepatic cholangiocarcinoma: A meta-analysis and systematic review"],"prefix":"10.3389","volume":"13","author":[{"given":"Xin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang-yi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-yun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man-yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-yang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze-hua","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31942","article-title":"Biliary tract cancer incidence and trends in the united states by demographic group, 1999-2013","volume":"125","author":"Van Dyke","year":"2019","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1053j\/gastro.2018.01.033","article-title":"Patterns and trends of liver cancer incidence rates in Eastern and southeastern Asian countries (1983-2007) and predictions to 2030","volume":"154","author":"Wu","year":"2018","journal-title":"Gastroenterology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016j\/jhep.2019.11.020","article-title":"Liver resection and transplantation for intrahepatic cholangiocarcinoma","volume":"72","author":"Mazzaferro","year":"2020","journal-title":"J Hepatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016j\/jhep.2022.05.043","article-title":"Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated tregs as a potential therapeutic target","volume":"77","author":"Alvisi","year":"2022","journal-title":"J Hepatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1640","article-title":"Geospatial immune heterogeneity reflects the diverse tumor-immune interactions in intrahepatic cholangiocarcinoma","volume":"12","author":"Lin","year":"2022","journal-title":"Cancer Discovery"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326514","article-title":"Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications","author":"Martin-Serrano","year":"2022","journal-title":"Gut"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.940009","article-title":"Efficacy and safety of drug-eluting beads transarterial chemoembolization combining immune checkpoint inhibitors in unresectable intrahepatic cholangiocarcinoma: A propensity score matching analysis","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.005","article-title":"Laparoscopic versus open liver resection for hepatocellular carcinoma: Case-matched study with propensity score matching","volume":"63","author":"Han","year":"2015","journal-title":"J Hepatol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002072","article-title":"Pure laparoscopic versus open right hepatectomy for hepatocellular carcinoma in patients with cirrhosis: A propensity score matched analysis","volume":"265","author":"Yoon","year":"2017","journal-title":"Ann Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ijsu.2017.12.021","article-title":"Laparoscopic vs open hepatectomy for hepatocellular carcinoma in patients with cirrhosis: A meta-analysis of the long-term survival outcomes","volume":"50","author":"Goh","year":"2018","journal-title":"Int J Surg"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znab376","article-title":"Laparoscopic versus open resection of hepatocellular carcinoma in patients with cirrhosis: meta-analysis","volume":"109","author":"Kabir","year":"2021","journal-title":"Br J Surg"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-017-1099-9","article-title":"Prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations","volume":"22","author":"Miyata","year":"2017","journal-title":"Int J Clin Oncol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003788","article-title":"Number and station of lymph node metastasis after curative-intent resection of intrahepatic cholangiocarcinoma impact prognosis","volume":"274","author":"Zhang","year":"2021","journal-title":"Ann.Surg"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-020-01877-0","article-title":"Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: the first meta-analysis","volume":"405","author":"Guerrini","year":"2020","journal-title":"Langenbecks Arch Surg"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-019-04404-9","article-title":"Is it time to consider laparoscopic hepatectomy for intrahepatic cholangiocarcinoma","volume":"24","author":"Wei","year":"2020","journal-title":"A Meta-Anal J Gastrointest Surg"},{"key":"B16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s13304-020-00930-3","article-title":"Meta-analysis of laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma","volume":"73","author":"Machairas","year":"2021","journal-title":"Updates Surg"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.11.310","article-title":"Is laparoscopic liver resection safe for intrahepatic cholangiocarcinoma? a meta-analysis","volume":"47","author":"Regmi","year":"2021","journal-title":"Eur J Surg Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2021.03.052","article-title":"Laparoscopic versus open hepatectomy for intrahepatic cholangiocarcinoma: An individual patient data survival meta-analysis","volume":"222","author":"Ziogas","year":"2021","journal-title":"Am J Surg"},{"key":"B19","doi-asserted-by":"publisher","first-page":"105906","DOI":"10.1016\/j.ijsu.2021.105918","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"88","author":"Page","year":"2021","journal-title":"Int J Surg"},{"key":"B20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med Res Methodol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2014.0233","article-title":"Laparoscopic liver resection for intrahepatic cholangiocarcinoma","volume":"25","author":"Uy","year":"2015","journal-title":"J Laparoendosc Adv Surg Tech. A"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-4817-x","article-title":"Comparison of perioperative and oncologic outcomes between open and laparoscopic liver resection for intrahepatic cholangiocarcinoma","volume":"30","author":"Lee","year":"2016","journal-title":"Surg Endosc"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5399-3","article-title":"Can laparoscopic liver resection provide a favorable option for patients with large or multiple intrahepatic cholangiocarcinomas","volume":"31","author":"Wei","year":"2017","journal-title":"Surg Endosc"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07303-0","article-title":"Laparoscopic approach to intrahepatic cholangiocarcinoma is associated with an exacerbatio\/n of inadequate nodal staging","volume":"26","author":"Martin","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018307","article-title":"Safety and feasibility of laparoscopic liver resection for patients with large or multiple intrahepatic cholangiocarcinomas: A propensity score based case-matched analysis from a single institute","volume":"98","author":"Zhu","year":"2019","journal-title":"Medicine"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2020.0215","article-title":"Laparoscopic liver resection for intrahepatic cholangiocarcinoma: A single-center experience","volume":"30","author":"Haber","year":"2020","journal-title":"J Laparoendosc Adv Surg Tech. A"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2020.01.001","article-title":"Laparoscopic liver resection versus open liver resection for intrahepatic cholangiocarcinoma: 3-year outcomes of a cohort study with propensity score matching","volume":"33","author":"Kang","year":"2020","journal-title":"Surg Oncol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/ases.12703","article-title":"Indications for laparoscopic liver resection of mass-forming intrahepatic cholangiocarcinoma","volume":"13","author":"Kinoshita","year":"2020","journal-title":"Asian J endoscopic Surg"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-020-07588-3","article-title":"Intrahepatic cholangiocarcinoma as the new field of implementation of laparoscopic liver resection programs. a comparative propensity score-based analysis of open and laparoscopic liver resections","volume":"35","author":"Ratti","year":"2020","journal-title":"Surg Endosc."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2020.03293","article-title":"Safety and feasibility of laparoscopic versus open liver resection with associated lymphadenectomy for intrahepatic cholangiocarcinoma","volume":"14","author":"Wu","year":"2020","journal-title":"Biosci Trends"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znaa110","article-title":"Laparoscopic versus open resection of intrahepatic cholangiocarcinoma: nationwide analysis","volume":"108","author":"Hobeika","year":"2021","journal-title":"Br J Surg"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.742544","article-title":"Laparoscopic versus open surgery for early-stage intrahepatic cholangiocarcinoma after mastering the learning curve: A multicenter data-based matched study","volume":"11","author":"Jinhuan","year":"2021","journal-title":"Front Oncol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12555","article-title":"Long-term outcomes of laparoscopic versus open liver resection for intrahepatic combined hepatocellular-cholangiocarcinoma with propensity score matching","author":"Lee","year":"2022","journal-title":"Ann Gastroenterol Surg"},{"key":"B34","article-title":"Safety and efficacy of laparoscopic hepatectomy for intrahepatic cholangiocarcinoma","volume":"27","author":"Chen","year":"2021","journal-title":"Chin J Hepatob Surg"},{"key":"B35","article-title":"Comparative study of laparoscopic surgery versus open surgery in the treatment of intrahepatic cholangiocarcinoma","volume":"27","author":"Ma","year":"2021","journal-title":"Chin J Hepatob Surg"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.08.015","article-title":"Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: Report of an international multicenter cohort study with propensity score matching","volume":"171","author":"Brustia","year":"2022","journal-title":"Surg"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-021-08842-y","article-title":"Selection criteria for minimally invasive resection of intrahepatic cholangiocarcinoma-a word of caution: a propensity score matched analysis using the national cancer database","volume":"36","author":"Salehi","year":"2022","journal-title":"Surg Endosc"},{"key":"B38","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000522403","article-title":"Liver cancer study group of Japan clinical practice guidelines for intrahepatic cholangiocarcinoma","volume":"11","author":"Kubo","year":"2022","journal-title":"Liver Cancer"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.01.021","article-title":"Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma","volume":"60","author":"Bridgewater","year":"2014","journal-title":"J Hepatol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.543","article-title":"Prognostic comparison of the 7th and 8th editions of the American joint committee on cancer staging system for intrahepatic cholangiocarcinoma","volume":"25","author":"Kang","year":"2018","journal-title":"J Hepatob Pancreat Sci"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.1298","article-title":"Comparison of hepatic arterial infusion pump chemotherapy vs resection for patients with multifocal intrahepatic cholangiocarcinoma","volume":"157","author":"Franssen","year":"2022","journal-title":"JAMA Surg"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znac075","article-title":"Repeat liver resection for recurrent intrahepatic cholangiocarcinoma: meta-analysis","volume":"109","author":"Ramouz","year":"2022","journal-title":"Br J Surg"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2019.05.006","article-title":"Extended resection of intrahepatic cholangiocarcinoma: A retrospective single-center cohort study","volume":"67","author":"Bartsch","year":"2019","journal-title":"Int J Surg"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2022.06.004","article-title":"Modification of the AJCC\/UICC 8th edition staging system for intrahepatic cholangiocarcinoma: proposal for an alternative staging system from cholangiocarcinoma-prevalent northeast Thailand","volume":"22","author":"Sa-Ngiamwibool","year":"2022","journal-title":"HPB (Oxford)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002640","article-title":"The OSLO-COMET randomized controlled trial of laparoscopic versus open resection for colorectal liver metastases","volume":"268","author":"Chan","year":"2018","journal-title":"Ann Surg"},{"key":"B46","doi-asserted-by":"publisher","first-page":"106678","DOI":"10.1016\/j.ijsu.2022.106678","article-title":"Laparoscopic versus open gastrectomy for gastric cancer: A systematic review and meta-analysis of randomized controlled trials","volume":"102","author":"Lou","year":"2022","journal-title":"Int J Surg"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000114","article-title":"Longer operative time: deterioration of clinical outcomes of laparoscopic colectomy versus open colectomy","volume":"57","author":"Bailey","year":"2014","journal-title":"Dis Colon Rectum"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.06.005","article-title":"Shorter operation time and improved surgical outcomes in laparoscopic donor right hepatectomy compared with open donor right hepatectomy","volume":"170","author":"Han","year":"2021","journal-title":"Surg"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3426-x","article-title":"Assessment of the lymph node status in patients undergoing liver resection for intrahepatic cholangiocarcinoma: the new eighth edition AJCC staging system","volume":"22","author":"Bagante","year":"2018","journal-title":"J Gastrointest Surg"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1096714\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T07:32:49Z","timestamp":1677655969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1096714\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":49,"alternative-id":["10.3389\/fonc.2023.1096714"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2023.1096714","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]},"article-number":"1096714"}}