{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:41:29Z","timestamp":1787809289423,"version":"build-2784847793"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Laparoscopic transduodenal ampullectomy (LTDA) is a function-preserving surgery for pre-malignant tumors of the ampulla of Vater (AoV). However, it is technically challenging, and only a few case reports of LTDA are available in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 43 cases of pre-malignant tumors of AoV were operated in West China Hospital, Sichuan University between January 2017 and July 2022. Among these patients, 9 patients (group 1) underwent LTDA, 19 patients (group 2) underwent laparoscopic pancreaticoduodenectomy (LPD), and 15 patients (group 3) underwent open transduodenal ampullectomy (OTDA). Prospective collection and retrospective analysis of the demographic characteristics, intraoperative variables, and postoperative variables were carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients in the three groups were comparable in terms of sex, age, body mass index, tumor size, and preoperative blood tests. In comparison to the patients in group 2, the patients in group 1 were found to require less operative time (159.7 \u00b1 47.5 min vs. 298.1 \u00b1 62.6, <jats:italic>p<\/jats:italic> &amp;lt; 0.01) and suffered lower blood losses (23.3 \u00b1 16.7 ml vs. 156.8 \u00b1 112.1, <jats:italic>p<\/jats:italic> = 0.002) and complications. Moreover, the postoperative hospital stays (POHS) were significantly shorter for patients in group 1 (9.0 \u00b1 5.3 days vs. 15.5 \u00b1 7.3 days, <jats:italic>p<\/jats:italic> = 0.04). Compared to patients who underwent OTDA, the patients in LTDA suffered from less blood loss. The operative time and post-operative details were comparable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therefore, LTDA was found to be safe and feasible in the setting of pre-malignant tumors of AoV in well-selected patients. However, multidisciplinary preoperative planning is essential before the surgery.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2023.1113490","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T09:24:14Z","timestamp":1689326654000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Laparoscopic transduodenal ampullectomy: initial experience from a single center"],"prefix":"10.3389","volume":"13","author":[{"given":"Pan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861001)58:7<1563::AID-CNCR2820580730>3.0.CO;2-E","article-title":"Benign villous adenomas of the ampulla of vater","volume":"58","author":"Rosenberg","year":"1986","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.14735\/amko201846","article-title":"Surgical treatment of ampullary adenocarcinoma - single center experience and a review of literature","volume":"31","author":"Kunovsk\u00fd","year":"2017","journal-title":"Klin Onkol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.3390\/cancers13092038","article-title":"Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer: Korean multicenter study","volume":"13","author":"Hong","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v7.i10.987","article-title":"Endoscopic papillectomy: the limits of the indication, technique and results","volume":"7","author":"Ardengh","year":"2015","journal-title":"World J Gastrointest Endosc"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i6.717","article-title":"Surgical method choice and coincidence rate of pathological diagnoses in transduodenal ampullectomy: a retrospective case series study and review of the literature","volume":"7","author":"Liu","year":"2019","journal-title":"World J Clin cases"},{"key":"B6","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1089\/lap.2009.0243","article-title":"Laparoscopic transduodenal ampullectomy for benign ampullary tumors","volume":"20","author":"Ahn","year":"2010","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.7602\/jmis.2022.25.2.73","article-title":"Which one will you choose; 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