{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T02:35:16Z","timestamp":1776479716444,"version":"3.51.2"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Medullary thyroid carcinoma (MTC) is a special type of thyroid carcinoma derived from the C cell of the thyroid gland. Because of the poor prognosis of MTC, a large number of studies on MTC have been conducted in the last 10 years. To better comprehend, it is necessary to clarify and define the dominant countries, organizations, core journals, important authors, and their cumulative research contributions, as well as the cooperative relationships between them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>English publications with article type article or review about MTC from January 2012 to December 2021 was retrieved from Web of Science core collection, and VOSviewer, CiteSpace, and Microsoft Excel were applied for bibliometric study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A total of 1208 articles and reviews were included in this study. The 1208 papers were written by 6364 authors from 1734 organizations in 67 countries, published in 408 journals, and cited 24118 references from 3562 journals. The number of publications was essentially flat from 2012-2021, with the largest proportion of publications coming from the U.S., followed by Italy and China. Thyroid was the most productive journal, and Journal of clinical endocrinology &amp;amp; metabolism was the most cited journal. University of Texas MD Anderson Cancer Center was the most productive institution and Luca Giovanella, was the most productive author. Diagnostic tools, surgical treatment, non-surgical treatment, genetics and relationship with other endocrine diseases were the main research interests in this field. Prognosis has been a cutting-edge topic since 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As a thyroid cancer with poor prognosis, MTC has received continuous attention in recent years. Current MTC studies mainly focused on disease intervention, mechanism research and prognosis. The main point of this study is to provide an overview of the development process and hot spots of MTC in the last decade. These might provide ideas for further research in the MTC field.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2023.1119915","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T14:39:27Z","timestamp":1678199967000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["A bibliometric analysis based on Web of Science from 2012 to 2021: Current situation, hot spots, and global trends of medullary thyroid carcinoma"],"prefix":"10.3389","volume":"13","author":[{"given":"Ruyin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zirui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)30172-6","article-title":"Thyroid cancer","volume":"388","author":"Cabanillas","year":"2016","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0415","article-title":"Thyroid cancer incidence trends in the united states: Association with changes in professional guideline recommendations","volume":"30","author":"Pereira","year":"2020","journal-title":"Thyroid"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3747\/co.26.5539","article-title":"Diagnosis and pathologic characteristics of medullary thyroid carcinoma-review of current guidelines","volume":"26","author":"Thomas","year":"2019","journal-title":"Curr Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22542-5_10","article-title":"Long-term follow-up in medullary thyroid carcinoma","volume":"204","author":"Raue","year":"2015","journal-title":"Recent Results Cancer Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1089\/thy.2014.0335","article-title":"Revised American thyroid association guidelines for the management of medullary thyroid carcinoma","volume":"25","author":"Wells","year":"2015","journal-title":"Thyroid"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.824201","article-title":"A bibliometric analysis of the landscape of parathyroid carcinoma research based on the pubmed (2000-2021)","volume":"12","author":"Feng","year":"2022","journal-title":"Front Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.977935","article-title":"Global research trend of esophageal squamous cell carcinoma from 2012 to 2022: A bibliometric analysis","volume":"12","author":"Zhang","year":"2022","journal-title":"Front Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.949993","article-title":"Bibliometric insights in advances of papillary thyroid microcarcinoma: Research situation, hot points, and global trends","volume":"13","author":"Chen","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.769807","article-title":"Bibliometric insights in advances of anaplastic thyroid cancer: Research landscapes, turning points, and global trends","volume":"11","author":"Wang","year":"2021","journal-title":"Front Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.21037\/gs-21-799","article-title":"Bibliometric analysis of research on thyroid ultrasonography","volume":"10","author":"Su","year":"2021","journal-title":"Gland Surg"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9492LSF","article-title":"Comparison of pubmed, scopus, web of science, and Google scholar: Strengths and weaknesses","volume":"22","author":"Falagas","year":"2008","journal-title":"FASEB J"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: Vosviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics"},{"key":"B13","article-title":"Citespace ii: Visualization and knowledge discovery in bibliographic databases","volume":"2005","author":"Synnestvedt","year":"2005","journal-title":"AMIA Annu Symp Proc"},{"key":"B14","first-page":"3","article-title":"Sources of information on specific subjects","volume":"23","year":"1934","journal-title":"Engineering"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23449","article-title":"Medullary thyroid cancer diagnosis: An appraisal","volume":"36","author":"Trimboli","year":"2014","journal-title":"Head Neck"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12563","article-title":"Detection rate of fna cytology in medullary thyroid carcinoma: A meta-analysis","volume":"82","author":"Trimboli","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12234","article-title":"Calcitonin measurement in aspiration needle washout fluids has higher sensitivity than cytology in detecting medullary thyroid cancer: A retrospective multicentre study","volume":"80","author":"Trimboli","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-014-0087-4","article-title":"Ultrasound features of medullary thyroid carcinoma correlate with cancer aggressiveness: A retrospective multicenter study","volume":"33","author":"Trimboli","year":"2014","journal-title":"J Exp Clin Cancer Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00259-019-04458-6","article-title":"Eanm practice guideline for Pet\/Ct imaging in medullary thyroid carcinoma","volume":"47","author":"Giovanella","year":"2020","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.48.4659","article-title":"Cabozantinib in progressive medullary thyroid cancer","volume":"31","author":"Elisei","year":"2013","journal-title":"J Clin Oncol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2046","article-title":"The timing of total thyroidectomy in ret gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years experience at one single center","volume":"97","author":"Elisei","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318268301d","article-title":"Prognostic impact of n staging in 715 medullary thyroid cancer patients: Proposal for a revised staging system","volume":"257","author":"Machens","year":"2013","journal-title":"Ann Surg"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182a6f43a","article-title":"Surgical curability of medullary thyroid cancer in multiple endocrine neoplasia 2b: A changing perspective","volume":"259","author":"Brauckhoff","year":"2014","journal-title":"Ann Surg"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.718418","article-title":"Continued discontinuation of tki treatment in medullary thyroid carcinoma - lessons from individual cases with long-term follow-up","volume":"12","author":"Brandenburg","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.755433","article-title":"Immunogenic cell death and immunomodulatory effects of cabozantinib","volume":"11","author":"Scirocchi","year":"2021","journal-title":"Front Oncol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-012-0060-6","article-title":"Cabozantinib for the treatment of advanced medullary thyroid cancer","volume":"29","author":"Nagilla","year":"2012","journal-title":"Adv Ther"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666171006165942","article-title":"Sunitinib in the treatment of thyroid cancer","volume":"26","author":"Ferrari","year":"2019","journal-title":"Curr Med Chem"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01491-3","article-title":"Lenvatinib as a salvage therapy for advanced metastatic medullary thyroid cancer","volume":"44","author":"Matrone","year":"2021","journal-title":"J Endocrinol Invest"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.815575","article-title":"Knowledge mapping of immunotherapy for hepatocellular carcinoma: A bibliometric study","volume":"13","author":"Shen","year":"2022","journal-title":"Front Immunol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1119915\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T14:39:32Z","timestamp":1678199972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1119915\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,7]]},"references-count":29,"alternative-id":["10.3389\/fonc.2023.1119915"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2023.1119915","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,7]]},"article-number":"1119915"}}