{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:56:58Z","timestamp":1759481818977,"version":"3.41.2"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Survival significance of the number of positive lymph nodes (LNs) in parotid adenoid cystic carcinoma (ACC) remains unknown; thus, this study aimed to determine the impact of the number of positive LNs on the prognosis of parotid ACC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with surgically treated parotid ACC were enrolled from the SEER database. The number of positive LNs was analyzed using three models (0 vs 1+, 0 vs 1 vs 2 vs 3 vs 4 vs 4 vs 5 vs 6+, 0\/1 vs 2\u20134 vs 5+), its hazard ratios on disease specific survival (DSS) and overall survival (OS) were assessed using univariate and multivariate Cox analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,689 patients were included. In all models, the number of positive LNs was independently related to DSS and OS, model 3 had the highest C-index for DSS [0.83 (95% CI: 0.81\u20130.85)] and OS [0.82 (95% CI: 0.80\u20130.84)]. Compared with the 0\/1 positive LN group, the 2\u20134 positive LN group had an HR of 2.81 (95% CI: 1.73\u20134.56) for DSS and 2.36 (95% CI: 1.58\u20133.54) for OS. The 5+ LN group had an HR of 20.15 (95% CI: 7.50\u201354.18) for DSS and 14.20 (95% CI: 5.45\u201336.97) for OS. No overlap existed in the 95% CI of the HR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The three prognostic categories based on the number of positive LNs (0\/1 vs 2\u20134 vs 5+) could stratify the DSS and OS in parotid ACC without overlap.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2023.1153186","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T07:15:50Z","timestamp":1679555750000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Number of positive lymph nodes affects outcomes in parotid adenoid cystic carcinoma"],"prefix":"10.3389","volume":"13","author":[{"given":"Feng","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105945","DOI":"10.1016\/j.oraloncology.2022.105945","article-title":"Current opinions on diagnosis and treatment of adenoid cystic carcinoma","volume":"130","author":"Fang","year":"2022","journal-title":"Oral Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23711","article-title":"Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma","volume":"37","author":"Amit","year":"2015","journal-title":"Int Collab study. 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