{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:31:26Z","timestamp":1791664286406,"version":"4.3.4"},"reference-count":90,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Cancer metastasis is a major cause of mortality from several tumors, including those of the breast, prostate, and the thyroid gland. Since bone tissue is one of the most common sites of metastasis, the treatment of bone metastases is crucial for the cure of cancer. Hence, disease models must be developed to understand the process of bone metastasis in order to devise therapies for it. Several translational models of different bone metastatic tumors have been developed, including animal models, cell line injection models, bone implant models, and patient-derived xenograft models. However, a compendium on different bone metastatic cancers is currently not available. Here, we have compiled several animal models derived from current experiments on bone metastasis, mostly involving breast and prostate cancer, to improve the development of preclinical models and promote the treatment of bone metastasis.<\/jats:p>","DOI":"10.3389\/fonc.2023.1165380","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T04:27:03Z","timestamp":1680668823000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Animal models of cancer metastasis to the bone"],"prefix":"10.3389","volume":"13","author":[{"given":"Yihan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanglu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengwu","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1089\/thy.2013.0149","article-title":"An in vivo mouse model of metastatic human thyroid cancer","volume":"24","author":"Zhang","year":"2014","journal-title":"Thyroid Off J Am Thyroid Assoc"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8997-3_17","article-title":"Animal models of breast cancer bone metastasis","volume":"1914","author":"Tulotta","year":"2019","journal-title":"Methods Mol Biol Clifton NJ"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-017-0021-z","article-title":"MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer","volume":"20","author":"Gawrzak","year":"2018","journal-title":"Nat Cell Biol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1038\/s41467-022-30105-0","article-title":"EZH2 engages TGF\u03b2 signaling to promote breast cancer bone metastasis via integrin \u03b21-FAK activation","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat Commun"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3109\/07357907.2015.1065500","article-title":"Animal models for breast cancer metastasis to bone: Opportunities and limitations","volume":"33","author":"Horas","year":"2015","journal-title":"Cancer Invest."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.08.001","article-title":"A glitch in the matrix: Organ-specific matrisomes in metastatic niches","volume":"32","author":"Deasy","year":"2022","journal-title":"Trends Cell Biol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-018-0020-2","article-title":"Translational models of prostate cancer bone metastasis","volume":"15","author":"Berish","year":"2018","journal-title":"Nat Rev Urol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202107787","article-title":"Siglec15 checkpoint blockade for simultaneous immunochemotherapy and osteolysis inhibition in lung adenocarcinoma spinal metastasis via a hollow nanoplatform","volume":"18","author":"Liang","year":"2022","journal-title":"Small Weinh Bergstr Ger"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.7150\/thno.54235","article-title":"Vertebral-specific activation of the CX3CL1\/ICAM-1 signaling network mediates non-small-cell lung cancer spinal metastasis by engaging tumor cell-vertebral bone marrow endothelial cell interactions","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30105-0","article-title":"Rat prostate adenocarcinoma cells disseminate to bone and adhere preferentially to bone marrow-derived endothelial cells","volume":"52","author":"Haq","year":"1992","journal-title":"Cancer Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-01010-2","article-title":"RUNX2 recruits the NuRD(MTA1)\/CRL4B complex to promote breast cancer progression and bone metastasis","volume":"29","author":"Yin","year":"2022","journal-title":"Cell Death Differ"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-3328","article-title":"Fam20C regulates bone resorption and breast cancer bone metastasis through osteopontin and BMP4","volume":"81","author":"Zuo","year":"2021","journal-title":"Cancer Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"556","DOI":"10.3390\/cancers14030556","article-title":"Spine metastases in immunocompromised mice after intracardiac injection of MDA-MB-231-SCP2 breast cancer cells","volume":"14","author":"Brylka","year":"2022","journal-title":"Cancers"},{"key":"B14","doi-asserted-by":"publisher","first-page":"E992","DOI":"10.1073\/pnas.1718009115","article-title":"HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice","volume":"115","author":"Devignes","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"B15","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.ccell.2017.11.002","article-title":"Therapeutic antibody targeting tumor- and osteoblastic niche-derived Jagged1 sensitizes bone metastasis to chemotherapy","volume":"32","author":"Zheng","year":"2017","journal-title":"Cancer Cell"},{"key":"B16","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s13046-018-0885-1","article-title":"BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer","volume":"37","author":"Ouarn\u00e9","year":"2018","journal-title":"J Exp Clin Cancer Res CR."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.3390\/ijms17081375","article-title":"Development of a patient-derived xenograft (PDX) of breast cancer bone metastasis in a zebrafish model","volume":"17","author":"Mercatali","year":"2016","journal-title":"Int J Mol Sci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2010.11.014","article-title":"The organization of the osteocyte network mirrors the extracellular matrix orientation in bone","volume":"173","author":"Kerschnitzki","year":"2011","journal-title":"J Struct Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.01.015","article-title":"Tumor microenvironment mechanisms and bone metastatic disease progression of prostate cancer","volume":"530","author":"Kang","year":"2022","journal-title":"Cancer Lett"},{"key":"B20","article-title":"Metastatic prostate cancer in a transgenic mouse","volume":"56","author":"Gingrich","year":"1996","journal-title":"Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0977-1","article-title":"Notch3 promotes prostate cancer-induced bone lesion development via MMP-3","volume":"39","author":"Ganguly","year":"2020","journal-title":"Oncogene"},{"key":"B22","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41413-021-00136-2","article-title":"Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases","volume":"9","author":"Polavaram","year":"2021","journal-title":"Bone Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41413-019-0072-9","article-title":"Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo","volume":"7","author":"Landgraf","year":"2019","journal-title":"Bone Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13046-021-01891-0","article-title":"Long non-coding RNA NORAD promotes the prostate cancer cell extracellular vesicle release via microRNA-541-3p-regulated PKM2 to induce bone metastasis of prostate cancer","volume":"40","author":"Hu","year":"2021","journal-title":"J Exp Clin Cancer Res CR."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0873-8","article-title":"EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis","volume":"38","author":"Li","year":"2019","journal-title":"Oncogene"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.45693","article-title":"Cancer stem cell property and gene signature in bone-metastatic breast cancer cells","volume":"16","author":"Luo","year":"2020","journal-title":"Int J Biol Sci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1026","article-title":"Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice","volume":"7","author":"Jenkins","year":"2005","journal-title":"Breast Cancer Res BCR"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32554","article-title":"GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer","volume":"146","author":"Sawada","year":"2020","journal-title":"Int J Cancer"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.10443","article-title":"Effect of CD133 overexpression on bone metastasis in prostate cancer cell line LNCaP","volume":"18","author":"Sohn","year":"2019","journal-title":"Oncol Lett"},{"key":"B30","doi-asserted-by":"publisher","first-page":"9227","DOI":"10.3390\/ijms21239227","article-title":"Gremlin-1 promotes metastasis of breast cancer cells by activating STAT3-MMP13 signaling pathway","volume":"21","author":"Sung","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.05.048","article-title":"Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice","volume":"44","author":"Marino","year":"2019","journal-title":"EBioMedicine"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0783","article-title":"Serum- and glucocorticoid-inducible kinase 1 is essential for osteoclastogenesis and promotes breast cancer bone metastasis","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol Cancer Ther"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3869","article-title":"A CTGF-RUNX2-RANKL axis in breast and prostate cancer cells promotes tumor progression in bone","volume":"35","author":"Kim","year":"2020","journal-title":"J Bone Miner Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"868","DOI":"10.3390\/cancers12040868","article-title":"TIE2 induces breast cancer cell dormancy and inhibits the development of osteolytic bone metastases","volume":"12","author":"Drescher","year":"2020","journal-title":"Cancers"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgz142","article-title":"Transactivation of SOX5 by brachyury promotes breast cancer bone metastasis","volume":"41","author":"Chen","year":"2020","journal-title":"Carcinogenesis"},{"key":"B36","article-title":"NAT1 promotes osteolytic metastasis in luminal breast cancer by regulating the bone metastatic niche via NF-\u03baB\/IL-1B signaling pathway","volume":"10","author":"Zhao","year":"2020","journal-title":"Am J Cancer Res"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0743","article-title":"Activation of canonical BMP4-SMAD7 signaling suppresses breast cancer metastasis","volume":"80","author":"Eckhardt","year":"2020","journal-title":"Cancer Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.3390\/cancers12103003","article-title":"Involvement of a transcription factor, Nfe2, in breast cancer metastasis to bone","volume":"12","author":"Zhang","year":"2020","journal-title":"Cancers"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15150","article-title":"Crucial contribution of GPR56\/ADGRG1, expressed by breast cancer cells, to bone metastasis formation","volume":"112","author":"Sasaki","year":"2021","journal-title":"Cancer Sci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s12935-019-0986-8","article-title":"Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer","volume":"19","author":"Sun","year":"2019","journal-title":"Cancer Cell Int"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-021-00178-6","article-title":"FOXA2 promotes prostate cancer growth in the bone","volume":"12","author":"Connelly","year":"2020","journal-title":"Am J Transl Res"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12876","article-title":"Non-invasively imageable tibia-tumor-fragment implantation experimental-bone-metastasis mouse model of GFP-expressing prostate cancer","volume":"36","author":"Aoki","year":"2022","journal-title":"Vivo Athens Greece"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01418-5","article-title":"Loss of EGR3 is an independent risk factor for metastatic progression in prostate cancer","volume":"39","author":"Shin","year":"2020","journal-title":"Oncogene"},{"key":"B44","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/s41419-018-0807-3","article-title":"Transcriptional downregulation of miR-133b by REST promotes prostate cancer metastasis to bone via activating TGF-\u03b2 signaling","volume":"9","author":"Huang","year":"2018","journal-title":"Cell Death Dis"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.01.018","article-title":"Loss of TGF-\u03b2 signaling in osteoblasts increases basic-FGF and promotes prostate cancer bone metastasis","volume":"418","author":"Meng","year":"2018","journal-title":"Cancer Lett"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56604","article-title":"MYBL2 disrupts the hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-19-0278","article-title":"A PSCA\/PGRN-NF-\u03baB-Integrin-\u03b14 axis promotes prostate cancer cell adhesion to bone marrow endothelium and enhances metastatic potential","volume":"18","author":"Zhao","year":"2020","journal-title":"Mol Cancer Res MCR"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24125","article-title":"Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo","volume":"81","author":"Thulin","year":"2021","journal-title":"Prostate"},{"key":"B49","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41413-021-00178-6","article-title":"GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation","volume":"10","author":"Siddiqui","year":"2022","journal-title":"Bone Res"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1038\/s41467-021-21976-w","article-title":"Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat Commun"},{"key":"B51","doi-asserted-by":"publisher","first-page":"100298","DOI":"10.1016\/j.jbo.2020.100298","article-title":"Optimization of a syngeneic murine model of bone metastasis","volume":"23","author":"Farhoodi","year":"2020","journal-title":"J Bone Oncol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14172","article-title":"Bone sialoprotein-\u03b1v\u03b23 integrin axis promotes breast cancer metastasis to the bone","volume":"110","author":"Wang","year":"2019","journal-title":"Cancer Sci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64934-6","article-title":"Optical imaging of cancer metastasis to bone marrow: A mouse model of minimal residual disease","volume":"160","author":"Wetterwald","year":"2002","journal-title":"Am J Pathol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0158","article-title":"Different molecular profiles are associated with breast cancer cell homing compared with colonisation of bone: Evidence using a novel bone-seeking cell line","volume":"21","author":"Nutter","year":"2014","journal-title":"Endocr Relat Cancer"},{"key":"B55","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13058-022-01502-6","article-title":"KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin\/c-myc signaling pathway","volume":"24","author":"Yin","year":"2022","journal-title":"Breast Cancer Res BCR"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-022-10150-1","article-title":"Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models","volume":"39","author":"Han","year":"2022","journal-title":"Clin Exp Metastasis"},{"key":"B57","article-title":"New model for the induction of osteoblastic bone metastases in rat","volume":"25","author":"Liepe","year":"2005","journal-title":"Anticancer Res"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-006-9002-5","article-title":"Rat models of bone metastases","volume":"22","author":"Blouin","year":"2005","journal-title":"Clin Exp Metastasis"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23187","article-title":"Relevance of a new rat model of osteoblastic metastases from prostate carcinoma for preclinical studies using zoledronic acid","volume":"122","author":"Lamoureux","year":"2008","journal-title":"Int J Cancer"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21010","article-title":"A novel model of bone-metastatic prostate cancer in immunocompetent mice","volume":"69","author":"Power","year":"2009","journal-title":"Prostate"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0736-3","article-title":"Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion","volume":"38","author":"Wang","year":"2019","journal-title":"Oncogene"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12634","article-title":"SMAD3\/SP1 complex-mediated constitutive active loop between lncRNA PCAT7 and TGF-\u03b2 signaling promotes prostate cancer bone metastasis","volume":"14","author":"Lang","year":"2020","journal-title":"Mol Oncol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.bcp.2014.06.005","article-title":"Trolox inhibits osteolytic bone metastasis of breast cancer through both PGE2-dependent and independent mechanisms","volume":"91","author":"Lee","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"115775","DOI":"10.1016\/j.bone.2020.115775","article-title":"Trefoil factor-1 upregulation in estrogen-receptor positive breast cancer correlates with an increased risk of bone metastasis","volume":"144","author":"Spadazzi","year":"2021","journal-title":"Bone"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.877536","article-title":"Modeling human prostate cancer metastasis in mice via resection of subcutaneous allografts","volume":"12","author":"Peiffer","year":"2022","journal-title":"Front Oncol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"6920","DOI":"10.1038\/s41467-021-26556-6","article-title":"Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis","volume":"12","author":"Yip","year":"2021","journal-title":"Nat Commun"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3791\/64589","article-title":"Intra-cardiac injection of human prostate cancer cells to create a bone metastasis xenograft mouse model","author":"Chang","year":"2022","journal-title":"J Vis Exp JoVE"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15532","article-title":"ICAM1 promotes bone metastasis via integrin-mediated TGF-\u03b2\/EMT signaling in triple-negative breast cancer","volume":"113","author":"Chen","year":"2022","journal-title":"Cancer Sci"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.10.001","article-title":"Fibroblast growth factor receptor 1 drives the metastatic progression of prostate cancer","volume":"5","author":"Labanca","year":"2022","journal-title":"Eur Urol Oncol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-21-0232","article-title":"Effective treatment of established bone metastases can be achieved by combinatorial osteoclast blockade and depletion of granulocytic subsets","volume":"9","author":"Capietto","year":"2021","journal-title":"Cancer Immunol Res"},{"key":"B71","doi-asserted-by":"publisher","first-page":"7689","DOI":"10.1038\/s41467-022-33938-x","article-title":"Regulation of bone homeostasis by MERTK and TYRO3","volume":"13","author":"Engelmann","year":"2022","journal-title":"Nat Commun"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf1383","article-title":"A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice","volume":"13","author":"Boudreau","year":"2021","journal-title":"Sci Transl Med"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0813-4","article-title":"Orthotopic models of cancer for preclinical drug evaluation: Advantages and disadvantages","volume":"40","author":"Bibby","year":"2004","journal-title":"Eur J Cancer Oxf Engl 1990"},{"key":"B74","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1038\/s41467-018-05366-3","article-title":"A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries","volume":"9","author":"Kuchimaru","year":"2018","journal-title":"Nat Commun"},{"key":"B75","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41388-018-0413-y","article-title":"The Lim1 oncogene as a new therapeutic target for metastatic human renal cell carcinoma","volume":"38","author":"Hamaidi","year":"2019","journal-title":"Oncogene"},{"key":"B76","first-page":"37","article-title":"Use of low-molecular-weight heparin to decrease mortality in mice after intracardiac injection of tumor cells","volume":"59","author":"Stocking","year":"2009","journal-title":"Comp Med"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2179","article-title":"Tumor microenvironment of metastasis in human breast carcinoma: A potential prognostic marker linked to hematogenous dissemination","volume":"15","author":"Robinson","year":"2009","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2013.07.010","article-title":"The metastatic microenvironment of breast cancer: Clinical implications","author":"Coleman","year":"2013","journal-title":"Breast Edinb Scotl"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-006-9044-8","article-title":"The application of a murine bone bioreactor as a model of tumor: bone interaction","volume":"23","author":"Halpern","year":"2006","journal-title":"Clin Exp Metastasis"},{"key":"B80","doi-asserted-by":"publisher","first-page":"170423","DOI":"10.1016\/j.peptides.2020.170423","article-title":"Neuronal calcitonin gene-related peptide promotes prostate tumor growth in the bone microenvironment","volume":"135","author":"Zhu","year":"2021","journal-title":"Peptides"},{"key":"B81","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-0-85729-293-3_7","article-title":"Methods in bone biology: Cancer and bone","volume-title":"Osteoporosis Res: Animal models","author":"Zheng","year":"2011"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-013-9437-5","article-title":"Humanised xenograft models of bone metastasis revisited: Novel insights into species-specific mechanisms of cancer cell osteotropism","volume":"32","author":"Holzapfel","year":"2013","journal-title":"Cancer Metastasis Rev"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.125394","article-title":"Next generation patient-derived prostate cancer xenograft models","volume":"16","author":"Lin","year":"2014","journal-title":"Asian J Androl."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58374","article-title":"SOX11 promotes epithelial\/mesenchymal hybrid state and alters tropism of invasive breast cancer cells","volume":"9","author":"Oliemuller","year":"2020","journal-title":"eLife"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-00125-0","article-title":"A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance","author":"Arriaga","year":"2020","journal-title":"Nat Cancer"},{"key":"B86","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3390\/cells10020430","article-title":"Knockdown of AKT3 activates HER2 and DDR kinases in bone-seeking breast cancer cells, promotes metastasis In vivo and attenuates the TGF\u03b2\/CTGF axis","volume":"10","author":"Hinz","year":"2021","journal-title":"Cells"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.907000","article-title":"NKX2-8\/PTHrP axis-mediated osteoclastogenesis and bone metastasis in breast cancer","volume":"12","author":"Abudourousuli","year":"2022","journal-title":"Front Oncol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126089","article-title":"Myeloid cell-derived PROS1 inhibits tumor metastasis by regulating inflammatory and immune responses via IL-10","volume":"131","author":"Maimon","year":"2021","journal-title":"J Clin Invest"},{"key":"B89","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12943-017-0746-0","article-title":"microRNA-124 inhibits bone metastasis of breast cancer by repressing interleukin-11","volume":"17","author":"Cai","year":"2018","journal-title":"Mol Cancer"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1172\/JCI157917","article-title":"IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer","volume":"132","author":"He","year":"2022","journal-title":"J Clin Invest"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1165380\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T04:27:11Z","timestamp":1680668831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1165380\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,5]]},"references-count":90,"alternative-id":["10.3389\/fonc.2023.1165380"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2023.1165380","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,5]]},"article-number":"1165380"}}