{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T06:39:12Z","timestamp":1788676752620,"version":"build-2803163510"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) are Gram-negative bacteria that cause chronic gastritis and are considered the main risk factor for the development of gastric cancer. <jats:italic>H. pylori<\/jats:italic> have evolved to survive the harsh luminal environment of the stomach and are known to cause damage and signaling aberrations in gastric epithelial cells, which can result in premalignant and malignant pathology. As well as colonizing the gastric mucus and surface epithelial cells, a subpopulation of <jats:italic>H. pylori<\/jats:italic> can invade deep into the gastric glands and directly interact with progenitor and stem cells. Gland colonization therefore bears the potential to cause direct injury to long-lived cells. Moreover, this bacterial subpopulation triggers a series of host responses that cause an enhanced proliferation of stem cells. Here, we review recent insights into how gastric gland colonization by <jats:italic>H. pylori<\/jats:italic> is established, the resulting pro-carcinogenic epithelial signaling alterations, as well as new insights into stem cell responses to infection. Together these point towards a critical role of gland-associated <jats:italic>H. pylori<\/jats:italic> in the development of gastric cancer.<\/jats:p>","DOI":"10.3389\/fonc.2023.1171003","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T04:39:25Z","timestamp":1682051965000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Unwelcome guests \u2013 the role of gland-associated Helicobacter pylori infection in gastric carcinogenesis"],"prefix":"10.3389","volume":"13","author":[{"given":"Giulia","family":"Beccaceci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"1","author":"Marshall","year":"1984","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.mib.2006.12.004","article-title":"The role of bacterial pathogens in cancer","volume":"10","author":"Vogelmann","year":"2007","journal-title":"Curr Opin Microbiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"7439","DOI":"10.3390\/ijms21207439","article-title":"Microbe-driven genotoxicity in gastrointestinal carcinogenesis","volume":"21","author":"Hartl","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B4","volume-title":"Helicobacter pylori eradication as a strategy for preventing gastric cancer","year":"2014"},{"key":"B5","first-page":"1","volume-title":"Schistosomes, liver flukes and helicobacter pylori","year":"1994"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022","article-title":"Global prevalence of helicobacter pylori infection: systematic review and meta-analysis","volume":"153","author":"Hooi","year":"2017","journal-title":"Gastroenterology"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.713955","article-title":"Helicobacter pylori in human stomach: the inconsistencies in clinical outcomes and the probable causes","volume":"12","author":"Alexander","year":"2021","journal-title":"Front Microbiol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28999","article-title":"Global burden of gastric cancer attributable to helicobacter pylori","volume":"136","author":"Plummer","year":"2015","journal-title":"Int J Cancer"},{"key":"B9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1146\/annurev.pathol.1.110304.100125","article-title":"The pathogenesis of helicobacter pylori-induced gastro-duodenal diseases","volume":"1","author":"Atherton","year":"2006","journal-title":"Annu Rev Pathol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"23227","DOI":"10.1038\/srep23227","article-title":"The CagA toxin of helicobacter pylori: abundant production but relatively low amount translocated","volume":"6","author":"Jim\u00e9nez-Soto","year":"2016","journal-title":"Sci Rep"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850166176","article-title":"Association of CagA-positive and CagA-negative helicobacter pylori strains with patients\u2019 symptoms and gastritis in primary care patients with functional upper abdominal complaints","volume":"33","author":"Heikkinen","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","article-title":"The gastric precancerous cascade","volume":"13","author":"Correa","year":"2012","journal-title":"J Dig Dis"},{"key":"B14","doi-asserted-by":"publisher","first-page":"7927054","DOI":"10.1155\/2020\/7927054","article-title":"The role of gastric mucosal immunity in gastric diseases","volume":"2020","author":"Nie","year":"2020","journal-title":"J Immunol Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"114338","DOI":"10.1016\/j.biopha.2023.114338","article-title":"Gastric immune homeostasis imbalance: an important factor in the development of gastric mucosal diseases","volume":"161","author":"Liu","year":"2023","journal-title":"BioMed Pharmacother"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.01.022","article-title":"Induction and regulation of the innate immune response in helicobacter pylori infection","volume":"13","author":"Gobert","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/diseases10030035","article-title":"Inflammation and gastric cancer","volume":"10","author":"Jaroenlapnopparat","year":"2022","journal-title":"Diseases"},{"key":"B18","doi-asserted-by":"publisher","first-page":"5477","DOI":"10.1038\/ncomms6477","article-title":"Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing","volume":"5","author":"Wong","year":"2014","journal-title":"Nat Commun"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","author":"Bass","year":"2014","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"5878","DOI":"10.1038\/s41467-022-33165-4","article-title":"Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis","volume":"13","author":"Aguilar","year":"2022","journal-title":"Nat Commun"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1053\/j.gastro.2015.02.049","article-title":"Helicobacter pylori activates and expands Lgr5(+) stem cells through direct colonization of the gastric glands","volume":"148","author":"Sigal","year":"2015","journal-title":"Gastroenterology"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00098-11","article-title":"ChePep controls helicobacter pylori infection of the gastric glands and chemotaxis in the epsilonproteobacteria","volume":"2","author":"Howitt","year":"2011","journal-title":"mBio"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000231","article-title":"High-resolution mapping reveals that microniches in the gastric glands control helicobacter pylori colonization of the stomach","volume":"17","author":"Fung","year":"2019","journal-title":"PloS Biol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3390\/toxins11110677","article-title":"Helicobacter pylori virulence factors exploiting gastric colonization and its pathogenicity","volume":"11","author":"Ansari","year":"2019","journal-title":"Toxins (Basel)"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006118","article-title":"Multiple acid sensors control helicobacter pylori colonization of the stomach","volume":"13","author":"Huang","year":"2017","journal-title":"PloS Pathog"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00071-16","article-title":"The helicobacter pylori CZB cytoplasmic chemoreceptor TlpD forms an autonomous polar chemotaxis signaling complex that mediates a tactic response to oxidative stress","volume":"198","author":"Collins","year":"2016","journal-title":"J Bacteriol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.tibs.2007.09.014","article-title":"Bacterial chemoreceptors: high-performance signaling in networked arrays","volume":"33","author":"Hazelbauer","year":"2008","journal-title":"Trends Biochem Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000395","article-title":"Helicobacter pylori senses bleach (HOCl) as a chemoattractant using a cytosolic chemoreceptor","volume":"17","author":"Perkins","year":"2019","journal-title":"PloS Biol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"14089","DOI":"10.1038\/s41598-017-14372-2","article-title":"Helicobacter pylori chemoreceptor TlpC mediates chemotaxis to lactate","volume":"7","author":"Machuca","year":"2017","journal-title":"Sci Rep"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01705-16","article-title":"Spatial and temporal shifts in bacterial biogeography and gland occupation during the development of a chronic infection","volume":"7","author":"Keilberg","year":"2016","journal-title":"mBio"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00878-17","article-title":"Chemotaxis allows bacteria to overcome host-generated reactive oxygen species that constrain gland colonization","volume":"86","author":"Collins","year":"2018","journal-title":"Infect Immun"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05762.x","article-title":"Relationship between helicobacter pylori hopQ genotype and clinical outcome in Asian and Western populations","volume":"24","author":"Ohno","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00293-09","article-title":"homB status of helicobacter pylori as a novel marker to distinguish gastric cancer from duodenal ulcer","volume":"47","author":"Jung","year":"2009","journal-title":"J Clin Microbiol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34781","article-title":"Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production","volume":"123","author":"Yamaoka","year":"2002","journal-title":"Gastroenterology"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2.2.110","article-title":"The turnover and shedding of epithelial cells. i. the turnover in the gastro-intestinal tract","volume":"2","author":"Creamer","year":"1961","journal-title":"Gut"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1095","article-title":"Helicobacter pylori VacA, a paradigm for toxin multifunctionality","volume":"3","author":"Cover","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.23.6361","article-title":"The n-terminal 34 kDa fragment of helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release","volume":"19","author":"Galmiche","year":"2000","journal-title":"EMBO J"},{"key":"B38","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.chom.2018.04.006","article-title":"Helicobacter pylori infection modulates host cell metabolism through VacA-dependent inhibition of mTORC1","volume":"23","author":"Kim","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308898200","article-title":"Helicobacter pylori VacA activates the p38\/activating transcription factor 2-mediated signal pathway in AZ-521 cells","volume":"279","author":"Nakayama","year":"2004","journal-title":"J Biol Chem"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.02.004","article-title":"The helicobacter pylori cag type IV secretion system","volume":"28","author":"Cover","year":"2020","journal-title":"Trends Microbiol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.VMBF-0012-2015","article-title":"Bacterial secretion systems: an overview","volume":"4","author":"Green","year":"2016","journal-title":"Microbiol Spectr"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802555R","article-title":"ADP heptose, a novel pathogen-associated molecular pattern identified in helicobacter pylori","volume":"33","author":"Pfannkuch","year":"2019","journal-title":"FASEB J"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13034","article-title":"Epidemiology and role of helicobacter pylori virulence factors in gastric cancer carcinogenesis","volume":"128","author":"Sukri","year":"2020","journal-title":"Apmis"},{"key":"B44","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3390\/toxins10040163","article-title":"Epidemiology of helicobacter pylori and CagA-positive infections and global variations in gastric cancer","volume":"10","author":"Park","year":"2018","journal-title":"Toxins (Basel)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15357","article-title":"Helicobacter pylori-induced DNA double-stranded break in the development of gastric cancer","volume":"113","author":"Murata-Kamiya","year":"2022","journal-title":"Cancer Sci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0343-8","article-title":"Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells","volume":"37","author":"Horvat","year":"2018","journal-title":"Oncogene"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2005.70.004","article-title":"p53-dependent and -independent functions of the arf tumor suppressor","volume":"70","author":"Sherr","year":"2005","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010628","article-title":"Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apoptosis","volume":"18","author":"Palrasu","year":"2022","journal-title":"PloS Pathog"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130015","article-title":"Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells","volume":"130","author":"Palrasu","year":"2020","journal-title":"J Clin Invest"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6757","article-title":"CagA promotes proliferation and inhibits apoptosis of GES-1 cells by upregulating TRAF1\/4-1BB","volume":"16","author":"Wang","year":"2017","journal-title":"Mol Med Rep"},{"key":"B51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12964-019-0323-9","article-title":"Helicobacter pylori-controlled c-abl localization promotes cell migration and limits apoptosis","volume":"17","author":"Posselt","year":"2019","journal-title":"Cell Commun Signal"},{"key":"B52","doi-asserted-by":"publisher","first-page":"8036","DOI":"10.1038\/s41598-017-08176-7","article-title":"Binding of the helicobacter pylori OipA causes apoptosis of host cells via modulation of Bax\/Bcl-2 levels","volume":"7","author":"Teymournejad","year":"2017","journal-title":"Sci Rep"},{"key":"B53","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41419-020-02894-z","article-title":"H. pylori infection confers resistance to apoptosis via Brd4-dependent BIRC3 eRNA synthesis","volume":"11","author":"Chen","year":"2020","journal-title":"Cell Death Dis"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.001008","article-title":"Role of partitioning-defective 1\/microtubule affinity-regulating kinases in the morphogenetic activity of helicobacter pylori CagA","volume":"284","author":"Lu","year":"2009","journal-title":"J Biol Chem"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307650","article-title":"Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells","volume":"64","author":"Wroblewski","year":"2015","journal-title":"Gut"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502598102","article-title":"Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells","volume":"102","author":"Bagnoli","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002050","article-title":"Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface","volume":"7","author":"Tan","year":"2011","journal-title":"PloS Pathog"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64373","article-title":"Iron deficiency accelerates helicobacter pylori-induced carcinogenesis in rodents and humans","volume":"123","author":"Noto","year":"2013","journal-title":"J Clin Invest"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1053\/j.gastro.2017.12.008","article-title":"Helicobacter pylori depletes cholesterol in gastric glands to prevent interferon gamma signaling and escape the inflammatory response","volume":"154","author":"Morey","year":"2018","journal-title":"Gastroenterology"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125581","article-title":"H. pylori infection alters repair of DNA double-strand breaks via SNHG17","volume":"130","author":"Han","year":"2020","journal-title":"J Clin Invest"},{"key":"B61","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.chom.2021.04.006","article-title":"Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis","volume":"29","author":"Imai","year":"2021","journal-title":"Cell Host Microbe"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.08.074","article-title":"H. pylori-induced DNA strand breaks are introduced by nucleotide excision repair endonucleases and promote NF-\u03baB target gene expression","volume":"13","author":"Hartung","year":"2015","journal-title":"Cell Rep"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.05.030","article-title":"Helicobacter pylori infection causes characteristic DNA damage patterns in human cells","volume":"11","author":"Koeppel","year":"2015","journal-title":"Cell Rep"},{"key":"B64","article-title":"Physiology, stomach","volume-title":"StatPearls [Internet]","author":"Hsu M","year":"2022"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092320208","article-title":"Identifying and counting epithelial cell types in the \u201ccorpus\u201d of the mouse stomach","volume":"232","author":"Karam","year":"1992","journal-title":"Anat Rec"},{"key":"B66","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.ydbio.2018.01.006","article-title":"Patterning the gastrointestinal epithelium to confer regional-specific functions","volume":"435","author":"Thompson","year":"2018","journal-title":"Dev Biol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/aja.1001640302","article-title":"Division of the mouse gastric mucosa into zymogenic and mucous regions on the basis of gland features","volume":"164","author":"Lee","year":"1982","journal-title":"Am J Anat"},{"key":"B68","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.stem.2009.11.013","article-title":"Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro","volume":"6","author":"Barker","year":"2010","journal-title":"Cell Stem Cell"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/nature23642","article-title":"Stromal r-spondin orchestrates gastric epithelial stem cells and gland homeostasis","volume":"548","author":"Sigal","year":"2017","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0339-9","article-title":"R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach","volume":"21","author":"Sigal","year":"2019","journal-title":"Nat Cell Biol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.10.003","article-title":"Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche","volume":"28","author":"Hayakawa","year":"2015","journal-title":"Cancer Cell"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.008","article-title":"Differentiated troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium","volume":"155","author":"Stange","year":"2013","journal-title":"Cell"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320742","article-title":"Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice","volume":"70","author":"Nienh\u00fcser","year":"2021","journal-title":"Gut"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2360-8","article-title":"H. pylori infection is associated with DNA damage of Lgr5-positive epithelial stem cells in the stomach of patients with gastric cancer","volume":"58","author":"Uehara","year":"2013","journal-title":"Dig Dis Sci"},{"key":"B75","doi-asserted-by":"publisher","first-page":"5117","DOI":"10.1038\/s41467-020-18857-z","article-title":"The ALPK1\/TIFA\/NF-\u03baB axis links a bacterial carcinogen to r-loop-induced replication stress","volume":"11","author":"Bauer","year":"2020","journal-title":"Nat Commun"},{"key":"B76","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1053\/j.gastro.2021.04.062","article-title":"EGF and BMPs govern differentiation and patterning in human gastric glands","volume":"161","author":"W\u00f6lffling","year":"2021","journal-title":"Gastroenterology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3390\/genes9030138","article-title":"Wnt signalling in intestinal stem cells: lessons from mice and flies","volume":"9","author":"Perochon","year":"2018","journal-title":"Genes (Basel)"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1086\/344321","article-title":"Gastric helicobacter species infection in murine and gerbil models: comparative analysis of effects of h. pylori and h. felis on gastric epithelial cell proliferation","volume":"186","author":"Court","year":"2002","journal-title":"J Infect Dis"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1038\/s41467-022-29176-w","article-title":"BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by h. pylori-driven inflammation","volume":"13","author":"Kapalczynska","year":"2022","journal-title":"Nat Commun"},{"key":"B80","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1053\/j.gastro.2014.04.015","article-title":"Anti-inflammatory activity of bone morphogenetic protein signaling pathways in stomachs of mice","volume":"147","author":"Takabayashi","year":"2014","journal-title":"Gastroenterology"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1172\/JCI151363","article-title":"R-spondin\/YAP axis promotes gastric oxyntic gland regeneration and helicobacter pylori-associated metaplasia in mice","volume":"132","author":"Fischer","year":"2022","journal-title":"J Clin Invest"},{"key":"B82","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.stem.2017.11.001","article-title":"YAP\/TAZ-dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration","volume":"22","author":"Yui","year":"2018","journal-title":"Cell Stem Cell"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021109996","article-title":"Gastric stem cells promote inflammation and gland remodeling in response to helicobacter pylori via Rspo3-Lgr4 axis","volume":"41","author":"Wizenty","year":"2022","journal-title":"EMBO J"},{"key":"B84","doi-asserted-by":"publisher","first-page":"112005","DOI":"10.1016\/j.celrep.2023.112005","article-title":"CDK1 bridges NF-\u03baB and \u03b2-catenin signaling in response to h. pylori infection in gastric tumorigenesis","volume":"42","author":"Zhu","year":"2023","journal-title":"Cell Rep"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314540","article-title":"Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defence against infection","volume":"68","author":"Boccellato","year":"2019","journal-title":"Gut"},{"key":"B86","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1053\/j.gastro.2014.09.042","article-title":"In vitro Expansion of human gastric epithelial stem cells and their responses to bacterial infection","volume":"148","author":"Bartfeld","year":"2015","journal-title":"Gastroenterology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.mib.2018.11.004","article-title":"Control of bacterial colonization in the glands and crypts","volume":"47","author":"Yang","year":"2019","journal-title":"Curr Opin Microbiol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1171003\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T04:39:28Z","timestamp":1682051968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1171003\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":87,"alternative-id":["10.3389\/fonc.2023.1171003"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2023.1171003","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,21]]},"article-number":"1171003"}}