{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:14:41Z","timestamp":1789600481925,"version":"build-2803163510"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to investigate the value of ultrasound combined with computed tomography (CT) in identifying early low-grade appendiceal mucinous neoplasm and appendicitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with early low-grade appendiceal mucinous neoplasm and appendicitis from September 2017 to September 2021, including 40 patients with low-grade appendiceal mucinous neoplasm and 40 patients with appendicitis, were collected in this study. Clinical data as well as ultrasound and CT findings of all patients were retrospectively analyzed. Univariate and multivariate logistic regression analyses were applied to establish the ultrasound model, the CT model, and the combined model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The nomogram showed that specific characteristics of CT were dilated appendiceal diameter and clear surrounding fat space in the low-grade appendiceal mucinous neoplasm and that specific characteristics of ultrasound were thin or clear layer appendix wall and flocculent echo in the appendix cavity. These four features were used to construct a nomogram for predicting early low-grade appendiceal mucinous neoplasm, and the area under the curve value was 0.839.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ultrasound combined with CT for diagnosis of early low-grade appendiceal mucinous neoplasm has a significant value; when found significantly dilated appendix in the lower right abdomen, with thin wall, wall calcification, clear surrounding fat space, and progressive enhancement, especially non-specific symptoms similar to appendicitis, the physician should timely consider the possibility of low-grade appendiceal mucinous neoplasm.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2023.1191785","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:45:52Z","timestamp":1696315552000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The value of ultrasound combined with CT in identifying early low-grade appendiceal mucinous neoplasm and appendicitis"],"prefix":"10.3389","volume":"13","author":[{"given":"Dong","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5588-2","article-title":"Low-grade appendiceal mucinous neoplasm of uncertain Malignant potential (LAMN-UMP): prognostic factors and implications for treatment and follow-up","volume":"24","author":"Fournier","year":"2017","journal-title":"Ann Surg Oncol"},{"key":"B2","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Nagtegaal","year":"2019"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i25.4015","article-title":"Unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis","volume":"19","author":"Yilmaz","year":"2013","journal-title":"World J Gastroenterol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1102\/1470-7330.2013.0003","article-title":"Mucinous neoplams of the appendix: a current comprehensive cliniclopathologic and imaging review","volume":"22","author":"Tirumni","year":"2013","journal-title":"Cancer Imaging"},{"key":"B5","first-page":"89","volume-title":"A Manual of Pathologica Anatomy.Vol 2","author":"Rokitansky","year":"1942"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197312)32:6<1525::AID-CNCR2820320632>3.0.CO;2-C","article-title":"Mucosal Hyperplasia, Mucinous cystadenoma and mucinous cystadenocarcinoma of the appendix","volume":"32","author":"Higa","year":"1973","journal-title":"Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/PAS.0000000000000535","article-title":"Consensus for Classification and pathologic reporting of pseudomyxoma peritonei and associated appendiceal neoplasia: the results of the peritoneal surface oncology group international (PSOGI) modified delphi process","volume":"40","author":"Carr","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/his.13324","article-title":"The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasm, appendiceal adenocarcinomas and pseudomyxoma peritonei","volume":"71","author":"Carr","year":"2017","journal-title":"Histopathology"},{"key":"B9","article-title":"Appendiceal mucinous neoplasm","volume-title":"WHO Classification of Tumours Editorial Board. 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