{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:38Z","timestamp":1753891838947,"version":"3.41.2"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>In Burkitt lymphoma (BL), a tumor of germinal center B cells, the pro-apoptotic properties of MYC are controlled by tonic B cell receptor (BCR) signals. Since BL cells do not exhibit constitutive NF-<jats:italic>\u03ba<\/jats:italic>B activity, we hypothesized that anti-apoptotic NFATc1 proteins provide a major transcriptional survival signal in BL. Here we show that post-transcriptional mechanisms are responsible for the calcineurin (CN) independent constitutive nuclear over-expression of NFATc1 in BL and <jats:italic>E\u00b5-MYC<\/jats:italic> \u2013 induced B cell lymphomas (BCL). Conditional inactivation of the <jats:italic>Nfatc1<\/jats:italic> gene in B cells of <jats:italic>E\u00b5-MYC<\/jats:italic> mice leads to apoptosis of BCL cells <jats:italic>in vivo<\/jats:italic> and <jats:italic>ex vivo<\/jats:italic>. Inhibition of BCR\/SYK\/BTK\/PI3K signals in BL cells results in cytosolic re-location of NFATc1 and apoptosis. Therefore, NFATc1 activity is an integrated part of tonic BCR signaling and an alternative target for therapeutic intervention in BL.<\/jats:p>","DOI":"10.3389\/fonc.2023.1205788","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T17:49:23Z","timestamp":1689961763000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcineurin-independent NFATc1 signaling is essential for survival of Burkitt lymphoma 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