{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:50:56Z","timestamp":1784735456582,"version":"3.55.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Primary cutaneous follicle center lymphoma (PCFCL) differs from follicular lymphoma in biological behavior and molecular profile and is treated as a distinct entity, according to the 5th edition of the World Health Organization classification of hematolymphoid tumors. It is an uncommon cutaneous B-cell lymphoma that is considerably rare in children and adolescents. To date, only 13 cases of individuals younger than 20 years of age have been reported in the literature. The lack of relevant clinical epidemiological data in this population has hampered the investigation of its clinical and diagnostic aspects. Here we report the case of a 17-year-old male with PCFCL, who may be the first PCFCL patient under 20 years of age reported in China. He was admitted to the hospital with a solitary nodule on his face. After complete surgical excision, the patient\u2019s facial mass was histologically identified as PCFCL. The patient\u2019s prognosis was favorable, with no recurrence at 17 months of follow-up after the surgical resection. We present a case of an adolescent PCFCL patient and systematically review the literature with a view to increase the awareness of the disease and inform the diagnosis and treatment of this age group.<\/jats:p>","DOI":"10.3389\/fonc.2023.1273719","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T16:50:59Z","timestamp":1698857459000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["An adolescent with primary cutaneous follicle center lymphoma: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Wen-Yan","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Shen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Lun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Guang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1728-2","article-title":"Clinical and treatment outcomes of primary cutaneous B-cell lymphoma: A single-center analysis in South Korea","volume":"101","author":"Kim","year":"2015","journal-title":"Int J Hematol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09121.x","article-title":"Juvenile onset of primary low-grade cutaneous B-cell lymphoma","volume":"161","author":"Amitay-Laish","year":"2009","journal-title":"Br J Dermatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/15513810802319442","article-title":"Primary cutaneous B-cell lymphoma in a child","volume":"27","author":"Condarco","year":"2008","journal-title":"Fetal Pediatr Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13939","article-title":"Primary cutaneous follicle center lymphoma in a 16-year-old girl","volume":"48","author":"Edmonds","year":"2021","journal-title":"J Cutan Pathol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.025","article-title":"Primary cutaneous follicular center cell lymphoma of the nose with maxillary sinus involvement in a pediatric patient","volume":"52","author":"Ghislanzoni","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002578","article-title":"Primary cutaneous Follicle Center Lymphoma in a 16-year-old boy with Crohn disease Exposed to infliximab and methotrexate","volume":"70","author":"Sayej","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21500.x","article-title":"The spectrum of cutaneous lymphomas in patients less than 20 years of age","volume":"21","author":"Fink-Puches","year":"2010","journal-title":"Pediatr Dermatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29630","article-title":"Primary cutaneous follicle center lymphoma of the medial canthus of the eye in an 11-year old","volume":"69","author":"D\u2019Alessandro","year":"2022","journal-title":"Pediatr Blood Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S396326","article-title":"Primary cutaneous follicle center lymphoma presenting as a solitary nodule on the forearm of an adolescent girl: A case report and literature review","volume":"16","author":"Al Harbi","year":"2023","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.07.021","article-title":"Primary cutaneous B-cell lymphomas in children and adolescents: A SEER population-based study","volume":"21","author":"Bomze","year":"2021","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268","article-title":"The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas","volume":"133","author":"Willemze","year":"2019","journal-title":"Blood"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2022.104109","article-title":"Cutaneous B-cell lymphomas: Update on diagnosis, risk-stratification, and management","volume":"51","author":"Fava","year":"2022","journal-title":"Presse Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP4SUBR4NPSPTN","article-title":"Diagnostic and prognostic value of BCL2 rearrangement in 53 patients with follicular lymphoma presenting as primary skin lesions","volume":"143","author":"Pham-Ledard","year":"2015","journal-title":"Am J Clin Pathol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00662","article-title":"BCL-2 expression in primary cutaneous follicle center B-cell lymphoma and its prognostic role","volume":"10","author":"Pileri","year":"2020","journal-title":"Front Oncol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26076","article-title":"Primary cutaneous lymphomas in children and adolescents","volume":"63","author":"Ceppi","year":"2016","journal-title":"Pediatr Blood Cancer"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-1083-1","article-title":"CLIPI: A new prognostic index for indolent cutaneous B cell lymphoma proposed by the International Extranodal Lymphoma Study Group (IELSG 11)","volume":"90","author":"Mian","year":"2011","journal-title":"Ann Hematol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-054601","article-title":"TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: A proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC)","volume":"110","author":"Kim","year":"2007","journal-title":"Blood"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.06.001","article-title":"Evaluation, diagnosis, and staging of cutaneous lymphoma","volume":"33","author":"Olsen","year":"2015","journal-title":"Dermatol Clin"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23863","article-title":"Cutaneous B-cell lymphomas: 2015 update on diagnosis, risk-stratification, and management","volume":"90","author":"Wilcox","year":"2015","journal-title":"Am J Hematol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"adv00383","DOI":"10.2340\/00015555-3746","article-title":"Long-term therapeutic success of intravenous rituximab in 26 patients with indolent primary cutaneous B-cell lymphoma","volume":"101","author":"Porkert","year":"2021","journal-title":"Acta Derm Venereol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.07.019","article-title":"Treatment and outcomes in patients with primary cutaneous B-cell lymphoma: The BC Cancer Agency experience","volume":"87","author":"Hamilton","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-019-01541-7","article-title":"De-escalated radiotherapy for indolent primary cutaneous B-cell lymphoma","volume":"196","author":"Oertel","year":"2020","journal-title":"Strahlenther Onkol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1273719\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T16:51:39Z","timestamp":1698857499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2023.1273719\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":22,"alternative-id":["10.3389\/fonc.2023.1273719"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2023.1273719","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,1]]},"article-number":"1273719"}}