{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T01:30:40Z","timestamp":1775698240543,"version":"3.50.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Testicular choriocarcinoma is a relatively rare malignancy with a highly aggressive nature. Timely diagnosis and treatment can help prolong the survival of patients and even cure them. This case reports a 29-year-old male who presented to the clinic for a month with epigastric pain. On examination, a massive mass of approximately 9*10 cm could be palpated in the upper abdomen. When asked about his previous history, the patient only described a history of a right inguinal hernia that had been repaired 12 years earlier. The admission diagnosis was considered the retroperitoneal tumor, which was found to have metastasized to the liver and lungs after the completion of relevant tests. We then performed a CT-guided lune puncture biopsy on day 8 of admission. The biopsy pathology suggested metastatic cancer was considered. As the symptoms of tumor compression gradually worsened, we performed surgical treatment (retroperitoneal tumor resection + partial duodenal resection + enteroanastomosis) on day 13 of admission. The postoperative pathology was choriocarcinoma. We subsequently conducted a detailed inquiry with the patient\u2019s family about his medical history and found a history of inguinal testicle. Through testicular ultrasound examination, it was preliminarily determined to be testicular choriocarcinoma (not yet pathologically confirmed). We wanted to start salvage chemotherapy as soon as possible after surgery. However, the patient\u2019s postoperative condition was poor, with rapid progression of hepatopulmonary metastases and gradually increased thyrotoxicosis, and we started salvage chemotherapy (EP regimen: etoposide and cisplatin) on postoperative day 12. However, the patient was forced to stop due to a severe chemotherapy reaction and died of respiratory and cardiac arrest in the hospital. For male patients with retroperitoneal mass, the possibility of germ-cell neoplasm should first be excluded. By inquiring in detail about a history of cryptorchidism and in the initial days of hospitalization, testicular exploration, ultrasounds, and serum tumor markers (AFP, \u03b2-HCG) tests can be conducted to rule out the possibility of germ-cell neoplasm, thereby preventing misdiagnosis and treatment delays. If the clinical diagnosis is metastatic germ-cell tumor with severe symptoms of metastatic disease, surgery should never be used as the initial treatment.<\/jats:p>","DOI":"10.3389\/fonc.2024.1223873","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T04:59:44Z","timestamp":1721192384000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case report: A case with atypical presentation oftesticular choriocarcinoma"],"prefix":"10.3389","volume":"14","author":[{"given":"Bin","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Dong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s11912-014-0430-0","article-title":"Testicular choriocarcinoma: a rare variant that requires a unique treatment approach","volume":"17","author":"Reilley","year":"2015","journal-title":"Curr Oncol Rep"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.03.017","article-title":"Survival after a diagnosis of testicular germ cell cancers in Germany and the United States, 2002-2006: a high resolution study by histology and age","volume":"37","author":"Stang","year":"2013","journal-title":"Cancer Epidemiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1053\/j.semdp.2022.07.001","article-title":"Germ cell neoplasms of the testis: Update for 2022","volume":"40","author":"Iczkowski","year":"2023","journal-title":"Semin Diagn pathology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"103568","DOI":"10.1016\/j.critrevonc.2021.103568","article-title":"High dose chemotherapy followed by autologous hematopoietic stem cell transplantation for advanced germ cell tumors: state of the art and a single-center experience","volume":"169","author":"Pierantoni","year":"2022","journal-title":"Crit Rev oncology\/hematology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/mco","article-title":"Pure testicular choriocarcinoma, a rare and highly Malignant subtype with challenging treatment: A case report and review of the literature","volume":"20","author":"Lei","year":"2024","journal-title":"Mol Clin Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"rjad064","DOI":"10.1093\/jscr\/rjad064","article-title":"Testicular choriocarcinoma: a rare diagnosis in a patient presenting with hemorrhagic shock","volume":"2023","author":"Mazzeo","year":"2023","journal-title":"J Surg Case Rep"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.2169\/internalmedicine.50.5442","article-title":"Unilateral gynecomastia in a young adult","volume":"50","author":"Lin","year":"2011","journal-title":"Internal Med (Tokyo Japan)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1407550","article-title":"Testicular cancer\u2013discoveries and updates","volume":"371","author":"Hanna","year":"2014","journal-title":"N Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"106634","DOI":"10.1016\/j.ijscr.2021.106634","article-title":"Unclear retroperitoneal tumors, an interdisciplinary challenge - 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