{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:16:03Z","timestamp":1781900163747,"version":"3.54.5"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The Mexican Social Security Institute (IMSS) was created in 1943 as the main public institution in Mexico.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 2020, the OncoCREAN (Centros de Referencia Estatal para la Atencio\u0301n del Ni\u00f1o y de la Ni\u00f1a con Ca\u0301ncer) strategy was established and consists of reference centers of Pediatric Oncology created to provide equitable access to pediatric patients with cancer in Mexico and toimprove the disease survival through standardized immunophenotyping, harmonized diagnosis, homogenized treatment, staff training, and complication response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 12 months of follow-up, overall survival is 89.9% in pediatric patients with acute lymphoblastic leukemia; we have no early death, and the main cause of death is still infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The current procedure in terms of immune molecular diagnosis is to send samples to the first national system of samples reference for the immunological diagnosis of leukemias based on immunophenotyping in the Cytomics Laboratory of the IMSS Research Center in Puebla, as a strong collaborative alliance. We present a narrative description of the strategy as preliminary results.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2024.1304640","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T10:51:08Z","timestamp":1757501468000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Equitable access to a personalized treatment with the OncoCREAN national strategy in pediatric patients with acute lymphoblastic leukemia from the Mexican Social Security Institute"],"prefix":"10.3389","volume":"14","author":[{"given":"Enrique","family":"Lopez Aguilar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeles","family":"Del Campo Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rioscovian 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