{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:59Z","timestamp":1787026979907,"version":"build-2736575974"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) is considered the most prevalent synchronous malignancy in patients with gastric cancer. This large retrospective study aims to clarify correlations between gastric histopathology stages and risks of specific colorectal neoplasms, to optimize screening and reduce preventable CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data of 36,708 patients undergoing gastroscopy and colonoscopy from 2005-2022 were retrospectively analyzed. Correlations between gastric and colorectal histopathology were assessed by multivariate analysis. Outcomes of interest included non-adenomatous polyps (NAP), conventional adenomas (CAs), serrated polyps (SPs), and CRC. Statistical analysis used R version 4.0.4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Older age (\u226550 years) and\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection (HPI) were associated with increased risks of conventional adenomas (CAs), serrated polyps (SPs), non-adenomatous polyps (NAP), and colorectal cancer (CRC). Moderate to severe intestinal metaplasia specifically increased risks of NAP and CAs by 1.17-fold (95% CI 1.05-1.3) and 1.19-fold (95% CI 1.09-1.31), respectively. For CRC risk, low-grade intraepithelial neoplasia increased risk by 1.41-fold (95% CI 1.08-1.84), while high-grade intraepithelial neoplasia (OR 3.76, 95% CI 2.25-6.29) and gastric cancer (OR 4.81, 95% CI 3.25-7.09) showed strong associations. More advanced gastric pathology was correlated with progressively higher risks of CRC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Precancerous gastric conditions are associated with increased colorectal neoplasm risk. Our findings can inform screening guidelines to target high-risk subgroups, advancing colorectal cancer prevention and reducing disease burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2024.1320020","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T13:17:13Z","timestamp":1708435033000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Retrospective cohort study investigating association between precancerous gastric lesions and colorectal neoplasm risk"],"prefix":"10.3389","volume":"14","author":[{"given":"Hui","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Long","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Ying","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Dai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ling","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jncc.2022.02.002","article-title":"Cancer incidence and mortality in China, 2016","volume":"2","author":"Zheng","year":"2022","journal-title":"J Natl Cancer Center"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastre.2022.03.001","article-title":"Surgical complications in a population-based colorectal cancer screening program: Incidence and associated factors","volume":"45","author":"S\u00e1nchez G\u00f3mez","year":"2022","journal-title":"Gastroenterol Hepatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.613948","article-title":"Clinical significance of colonoscopic examination in patients with early stage of gastric neoplasm undergoing endoscopic submucosal dissection","volume":"46","author":"Lee","year":"2011","journal-title":"Scand J Gastroenterol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07128.x","article-title":"Metabolic syndrome is an independent risk factor for synchronous colorectal neoplasm in patients with gastric neoplasm","volume":"27","author":"Park","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2824-5","article-title":"Is colonoscopic screening necessary for patients with gastric adenoma or cancer","volume":"58","author":"Kim","year":"2013","journal-title":"Dig Dis Sci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3393\/jksc.2011.27.5.246","article-title":"The synchronous prevalence of colorectal neoplasms in patients with stomach cancer","volume":"27","author":"Lee","year":"2011","journal-title":"J Korean Soc Coloproctol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2737-0","article-title":"Role of preoperative colonoscopy in patients with gastric cancer: a case control study of the prevalence of coexisting colorectal neoplasms","volume":"20","author":"Yoo","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/apt.2013.38.issue-4","article-title":"Review article: historic changes of Helicobacter pylori-associated diseases","volume":"38","author":"Sonnenberg","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v5.i5.240","article-title":"Risk of colorectal polyps in patients with sporadic gastric polyps: A case-control study","volume":"5","author":"Cimmino","year":"2013","journal-title":"World J Gastrointest Endosc"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-3-13","article-title":"Gastric fundic gland polyps and colonic polyps - 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