{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:21:05Z","timestamp":1791652865132,"version":"4.3.4"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors affecting the gastrointestinal tract. Typically, GISTs are solitary; however, in rare cases, they may be multiple and appear in one or more organs. Multiple GISTs can appear in familial GISTs, children, or certain tumor syndromes such as neurofibromatosis type 1, Carney syndrome, and Carney-Stratakis syndrome. However, the diagnosis of primary multiple sporadic GISTs is often more difficult than that of these diseases. Herein, we report a case of multiple primary sporadic GISTs in a 64-year-old man, affecting the abdominal cavity and retroperitoneum, as identified through dual-time point positron emission tomography (PET) with <jats:sup>18<\/jats:sup>F-labeled fluoro-2-deoxyglucose (<jats:sup>18<\/jats:sup>F-FDG) and computed tomography (<jats:sup>18<\/jats:sup>F-FDG PET\/CT). Notably, the dual-time-point PET\/CT revealed the migration of masses near the lower abdomen into the abdominal cavity. Furthermore, a significant increase in radioactive uptake of the mass 3\u00a0h after <jats:sup>18<\/jats:sup>F-FDG injection compared with that 1\u00a0h after injection may be an important cue for its diagnosis.<\/jats:p>","DOI":"10.3389\/fonc.2024.1321179","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:53:04Z","timestamp":1711601584000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case report: detection of multiple sporadic gastrointestinal stromal tumors by dual-time 18 F-FDG PET\/CT"],"prefix":"10.3389","volume":"14","author":[{"given":"Chuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maocai","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60106-3","article-title":"Gastrointestinal stromal tumour","volume":"382","author":"Joensuu","year":"2013","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22123","article-title":"Gastrointestinal stromal tumors (GIST) in children and adolescents: A comprehensive review of the current literature","volume":"53","author":"Benesch","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.009","article-title":"Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred","volume":"23","author":"Li","year":"2005","journal-title":"J Clin Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0514-z","article-title":"Neurofibromatosis type 1-related gastrointestinal stromal tumors: a special reference to loss of heterozygosity at 14q and 22q","volume":"135","author":"Yamamoto","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10235","article-title":"Familial paraganglioma and gastric stromal sarcoma: a new syndrome distinct from the Carney triad","volume":"108","author":"Carney","year":"2002","journal-title":"Am J Med Genet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/sj.ejhg.5201904","article-title":"Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD","volume":"16","author":"Pasini","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213318.66800.94","article-title":"Multiple gastrointestinal stromal tumors: Clinicopathologic and genetic analysis of 12 patients","volume":"31","author":"Kang","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213440.78407.27","article-title":"Multicentric sporadic gastrointestinal stromal tumors (GISTs) of the stomach with distinct clonal origin: differential diagnosis to familial and syndromal GIST variants and peritoneal metastasis","volume":"31","author":"Haller","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0622","article-title":"Multiple primary sporadic gastrointestinal stromal tumors in the adult: an underestimated entity","volume":"14","author":"Gasparotto","year":"2008","journal-title":"Clin Cancer Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2705","article-title":"Extragastrointestinal stromal tumors: Computed tomography and magnetic resonance imaging findings","volume":"9","author":"Zhu","year":"2015","journal-title":"Oncol Lett"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S197560","article-title":"Multiple gastrointestinal stromal tumors: analysis of clinicopathologic characteristics and prognosis of 20 patients","volume":"11","author":"Li","year":"2019","journal-title":"Cancer Manag Res"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817587ea","article-title":"Multiple sporadic gastrointestinal stromal tumors (GISTs) of the proximal stomach are caused by different somatic KIT mutations suggesting a field effect","volume":"32","author":"Agaimy","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0803-1","article-title":"Multiple sporadic gastrointestinal stromal tumours arising at different gastrointestinal sites: pattern of involvement of the muscularis propria as a clue to independent primary GISTs","volume":"455","author":"Agaimy","year":"2009","journal-title":"Virchows Arch"},{"key":"B14","article-title":"Diagnostic relevance of overexpressions of PKC-\u03b8 and DOG-1 and KIT\/PDGFRA gene mutations in extragastrointestinal stromal tumors: a Korean six-centers study of 28 cases","volume":"32","author":"Kim","year":"2012","journal-title":"Anticancer Res"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-005-2647-7","article-title":"Gastrointestinal stromal tumors: CT and MRI findings","volume":"15","author":"Sandrasegaran","year":"2005","journal-title":"Eur Radiol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000156","article-title":"Diagnosis and treatment of duodenal gastrointestinal stromal tumors","volume":"11","author":"Du","year":"2020","journal-title":"Clin Transl Gastroenterol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-022-01305-x","article-title":"Gastrointestinal stromal tumors: a comprehensive radiological review","volume":"40","author":"Inoue","year":"2022","journal-title":"Jpn J Radiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1967\/s002449912407","article-title":"(18)F-FDG PET\/CT in GIST treatment response evaluation beyond Imatinib","volume":"24","author":"Altini","year":"2021","journal-title":"Hell J Nucl Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"iv267","DOI":"10.1093\/annonc\/mdy320","article-title":"Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Casali","year":"2018","journal-title":"Ann Oncol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.57.270","article-title":"Relationship between FDG uptake and the pathological risk category in gastrointestinal stromal tumors","volume":"57","author":"Otomi","year":"2010","journal-title":"J Med Invest"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1967\/s002449912212","article-title":"A rare case of multiple primary extragastrointestinal stromal tumors in the abdominopelvic cavity detected by (18)F-FDG PET\/CT","volume":"23","author":"Xiao","year":"2020","journal-title":"Hell J Nucl Med"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.remn.2018.06.004","article-title":"Inflammatory myofibroblastic tumor. (18)F-FDG PET\/CT findings","volume":"38","author":"D\u00edaz Silv\u00e1n","year":"2019","journal-title":"Rev Esp Med Nucl Imagen Mol (Engl Ed)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182952caa","article-title":"Inflammatory myofibroblastic tumor: FDG PET\/CT findings with pathologic correlation","volume":"39","author":"Dong","year":"2014","journal-title":"Clin Nucl Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000001404","article-title":"18F-FDG PET\/CT imaging features of patients with multicentric Castleman disease","volume":"42","author":"Jiang","year":"2021","journal-title":"Nucl Med Commun"},{"key":"B25","doi-asserted-by":"publisher","first-page":"11073","DOI":"10.1038\/s41598-019-47453-5","article-title":"Relationship between semiquantitative (18)F-fluorodeoxyglucose positron emission tomography metrics and necrosis in classical Hodgkin lymphoma","volume":"9","author":"Kahle","year":"2019","journal-title":"Sci Rep"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.01.005","article-title":"Clinicopathological and molecular features of a large cohort of gastrointestinal stromal GISTs are rare events","volume":"62","author":"Huss","year":"2017","journal-title":"Hum Pathol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/82_2011_161","article-title":"Gastrointestinal stromal tumors","volume":"355","author":"Antonescu","year":"2012","journal-title":"Curr Top Microbiol Immunol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.04.005","article-title":"Diagnosis, prognosis and treatment of patients with gastrointestinal stromal tumour (GIST) and germline mutation of KIT exon 13","volume":"49","author":"Bachet","year":"2013","journal-title":"Eur J Cancer"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70299-6","article-title":"Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts","volume":"13","author":"Joensuu","year":"2012","journal-title":"Lancet Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1321179\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:53:19Z","timestamp":1711601599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1321179\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":29,"alternative-id":["10.3389\/fonc.2024.1321179"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2024.1321179","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]},"article-number":"1321179"}}