{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:49:49Z","timestamp":1781279389862,"version":"3.54.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Benign Brenner tumor (BBT) is a rare ovarian tumor, and there are few discrete reports about its manifestation in an ultrasound. This study sought to investigate the two-dimensional (2D) and contrast-enhanced ultrasound (CEUS) features of this entity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective single-center study. The clinical manifestations, laboratory examination, and ultrasound data of 25 female patients with BBT were confirmed by pathology when they underwent 2D and\/or CEUS examination at Ningbo First Hospital from January 2012 to June 2023. The ultrasound findings of the patients were analyzed using the terminology of the International Organization for the Analysis of Ovarian Tumor and were read by two senior sonographers who reached an agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the all 25 patients, most of them were unilateral, and only one patient was bilateral. Thus, 26 lesions were found: 44.0% (11\/25) were in the left and 52.0% (13\/25) were in the right. Moreover, 53.84% (14\/26) were solid lesions, 15.38% (4\/26) were mixed lesions, and 26.92% (7\/26) were cystic lesions. Among the solid-type patients, 42.85% (6\/14) of the cases were with calcification. Upon laboratory examination, 12.0% (3\/25) of the patients had high carbohydrate antigen 125 (CA-125) level, and 19.04% (4\/21) of the patients had an elevated carbohydrate antigen724 (CA-724) level in the serum tumor markers. In the hormone test, 14.28% (3\/21) were found to have a high postmenopausal estrogen level and 14.28%(3\/21) were found to have a high level of follicle-stimulating hormone (FSH). One patient with complex manifestations and three with solid manifestations were examined by CEUS to observe the microcirculation perfusion of the tumor. One with solid and cystic separation was rapidly hyperenhanced and cleared, and the filling subsided faster than the uterus. The postoperative pathological diagnosis was benign Brenner tumor with mucinous cystadenoma. The other three cases were solid adnexal lesions, which showed isoenhancement on CEUS and disappeared slowly, synchronizing with the uterus. The CEUS results were considered as benign tumors and confirmed by pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BBT can show ovarian cystic, mixed cystic and solid type, and solid echo in 2D ultrasound. Unilateral ovarian fibrosis with punctate calcification is an important feature of BBT in 2D ultrasound. However, for solid adnexal masses and mixed cystic and solid masses with unclear diagnosis, if CEUS shows isoenhancement or hyperenhancement, the possibility of BBT cannot be excluded.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2024.1337806","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T13:35:33Z","timestamp":1709904933000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Benign Brenner tumor of the ovary: two-dimensional and contrast-enhanced ultrasound features\u2014a retrospective study from a single center"],"prefix":"10.3389","volume":"14","author":[{"given":"Mei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusheng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiya","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiupeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(77)80117-2","article-title":"Bilateral Brenner tumors: a case report and review of the literature","volume":"8","author":"Lamping","year":"1977","journal-title":"Hum Pathol"},{"key":"B2","first-page":"791","article-title":"Surface epithelial cells of the ovary","volume-title":"Blaustein\u2019s Pathology of the Female genital tract","author":"Seidman","year":"2002"},{"key":"B3","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s00404-016-4073-2","article-title":"The new WHO classification of ovarian, allopian tube, and primary peritoneal cancer and its clinical implications","volume":"293","author":"Meinhold-Heerlein","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-012-9887-1","article-title":"Ovarian mucinous cystadenoma coexisting with benign Brenner tumor: MR imaging findings","volume":"38","author":"Kato","year":"2013","journal-title":"Abdom Imaging"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.04.538","article-title":"Malignant Brenner tumors of the ovary; a population-based analysis","volume":"142","author":"Nasioudis","year":"2016","journal-title":"Gynecol Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197109)28:3<588::aid-cncr2820280310>3.0.co;2-j","article-title":"Brenner tumor of the ovary: A clinicopathologic study of 60 tumors in 54 women","volume":"28","author":"Silverberg","year":"1971","journal-title":"Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1002\/1097-0142(19850801)56:3<592::aid-cncr2820560328>3.0.co;2-a","article-title":"Ovarian brenner tumors. 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