{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:35:50Z","timestamp":1793745350061,"version":"4.6.1"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002703","name":"Jiangsu University","doi-asserted-by":"publisher","award":["No. jdfyRC2017003, No. BGYCB202203, JDYY2023004"],"award-info":[{"award-number":["No. jdfyRC2017003, No. BGYCB202203, JDYY2023004"]}],"id":[{"id":"10.13039\/501100002703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Screening and postoperative intervention of breast tumors are critical for the effective diagnosis and treatment of disease development, and reliable diagnostic\/screening methods become a key link. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Thromboelastogram (TEG), routine platelet (PLT) count, and the coagulation function indicators in patients with different breast diseases were determined and analyzed to explore their predictive value in secondary bleeding disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 131 patients with breast diseases, admitted to Jiangsu University Affiliated Hospital from January 2019 to December 2022, were selected as the research subjects. The detection items were analyzed using the receiver operating curve (ROC) after grouping for secondary bleeding disorders of patients with breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The reaction (<jats:italic>R<\/jats:italic>) and the coagulation (<jats:italic>K<\/jats:italic>) times were lower in the malignant breast disease group, while the coagulation angle (<jats:italic>\u03b1<\/jats:italic>), maximum amplitude (MA), coagulation index (CI), fibrinogen (FIB), and D-dimer (D-D) were higher than those in the benign breast disease group. The <jats:italic>t<\/jats:italic>-tests proved that the MA and FIB values were statistically significant (<jats:italic>p<\/jats:italic> &amp;lt; 0.05) in the benign and malignant breast disease groups. The <jats:italic>R<\/jats:italic> and <jats:italic>K<\/jats:italic> in patients with breast diseases were positively correlated with the activated partial thromboplastin time (aPTT) and D-D, but were negatively correlated with PLT. The <jats:italic>\u03b1<\/jats:italic> angle was negatively correlated with aPTT and D-D, but was positively correlated with PLT. The MA for PLT function was positively correlated with FIB and PLT. CI was negatively correlated with aPTT, thrombin time (TT), and D-D, but was positively correlated with PLT. ROC curve analysis showed that the CI and <jats:italic>\u03b1<\/jats:italic> angle had a significant predictive value, whereas the correlation of the other indicators was relatively low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Coagulation tests showed significant differences in patients with breast cancer, differing from those with benign breast diseases. TEG combined with conventional coagulation indicators is potentially valuable for the prediction of secondary bleeding disorders in patients with breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2024.1342439","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T04:58:52Z","timestamp":1721192332000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Thromboelastogram and coagulation function index: relevance for female breast cancer"],"prefix":"10.3389","volume":"14","author":[{"given":"Qiongle","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(59)90379-0","article-title":"Armand trousseau: Lecture on angina pectoris","volume":"3","author":"Jarcho","year":"1959","journal-title":"Am J Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12943-021-01347-1","article-title":"Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell","volume":"20","author":"Ward","year":"2021","journal-title":"Mol Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41572-022-00336-y","article-title":"Cancer-associated venous thromboembolism","volume":"8","author":"Khorana","year":"2022","journal-title":"Nat Rev Dis Primers"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2020190097","article-title":"Venous thrombosis and hypercoagulability in the abdomen and pelvis: Causes and imaging findings","volume":"40","author":"Olson","year":"2020","journal-title":"RadioGraphics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0140-6736(20)32658-1","article-title":"Venous thromboembolism","volume":"398","author":"Khan","year":"2021","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2020.12.001","article-title":"Overview of myeloproliferative neoplasms: History, pathogenesis, diagnostic criteria, and complications","volume":"35","author":"Tremblay","year":"2021","journal-title":"Hematology\/Oncol Clinics"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S227171","article-title":"The research progress on the prognostic value of the common hematological parameters in peripheral venous blood in breast cancer","volume":"13","author":"Chen","year":"2020","journal-title":"OncoTargets Ther"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.08.259","article-title":"Clinical approach to splanchnic vein thrombosis: Risk factors and treatment","volume":"130","author":"Riva","year":"2012","journal-title":"Thromb Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.ejcts.2007.07.029","article-title":"Non-bacterial thrombotic endocarditis","volume":"32","author":"Asopa","year":"2007","journal-title":"Eur J Cardio-Thoracic Surg"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15106","article-title":"Tissue factor and its procoagulant activity on cancer-associated thromboembolism in pancreatic cancer","volume":"112","author":"Kobayashi","year":"2021","journal-title":"Cancer Sci"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15880","article-title":"Hemostasis and cancer: Impact of haemostatic biomarkers for the prediction of clinical outcomes in patients with cancer","volume":"20","author":"Moik","year":"2022","journal-title":"J Thromb Haemostasis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02497.x","article-title":"Cancer and thrombosis: from molecular mechanisms to clinical presentations","volume":"5","author":"Buller","year":"2007","journal-title":"J Thromb Haemostasis"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200408000-00012","article-title":"Platelet adhesion in breast cancer: development and application of a novel assay","volume":"15","author":"Caine","year":"2004","journal-title":"Blood Coagulation Fibrinolysis"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188727","article-title":"Coagulation and inflammation in cancer: Limitations and prospects for treatment","volume":"1877","author":"Singh","year":"2022","journal-title":"Biochim Biophys Acta (BBA) - Rev Cancer"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2022.101642","article-title":"Complement activation in cancer: Effects on tumor-associated myeloid cells and immunosuppression","volume":"60","author":"Magrini","year":"2022","journal-title":"Semin Immunol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2022.101349","article-title":"Blood coagulation and cancer genes","volume":"35","author":"Tawil","year":"2022","journal-title":"Best Pract Res Clin Haematol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(12)70012-9","article-title":"Genetic pathways linking hemostasis and cancer","volume":"129","author":"Garnier","year":"2012","journal-title":"Thromb Res"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2022.12.001","article-title":"Cyclin-dependent kinase 4\/6 inhibitor-associated thromboembolism: a critical evaluation of the current evidence","volume":"21","author":"Watson","year":"2023","journal-title":"J Thromb Haemostasis"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12075","article-title":"Coagulation and cancer: biological and clinical aspects","volume":"11","author":"Falanga","year":"2013","journal-title":"J Thromb Haemostasis"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2009.03.008","article-title":"An overview of coagulation disorders in cancer patients","volume":"19","author":"Kvolik","year":"2010","journal-title":"Surg Oncol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.10.011","article-title":"Hypercoagulation and complement: Connected players in tumor development and metastases","volume":"28","author":"Guglietta","year":"2016","journal-title":"Semin Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030566","article-title":"Potential mechanisms of cancer-related hypercoagulability","author":"Nasser","year":"2020","journal-title":"In: Cancers"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-019-02197-6","article-title":"Circulating tumour cells and hypercoagulability: a lethal relationship in metastatic breast cancer","volume":"22","author":"Kirwan","year":"2020","journal-title":"Clin Trans Oncol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0510-x","article-title":"The relationship between pancreatic cancer and hypercoagulability: a comprehensive review on epidemiological and biological issues","volume":"121","author":"Campello","year":"2019","journal-title":"Br J Cancer"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-023-03390-z","article-title":"Venous Thromboembolism: Review of clinical challenges, biology, assessment, treatment, and modeling","volume":"52","author":"Watson","year":"2024","journal-title":"Ann Biomed Eng"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000002314","article-title":"What proportion of patients with musculoskeletal tumors demonstrate thromboelastographic markers of hypercoagulability","volume":"481","author":"Sabharwal","year":"2023","journal-title":"A pilot study Clin Orthopaedics Related Research\u00ae"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s11831-020-09470-w","article-title":"Breast cancer detection, segmentation and classification on histopathology images analysis: A systematic review","volume":"28","author":"Krithiga","year":"2021","journal-title":"Arch Comput Methods Eng"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12748","article-title":"Intra- and inter-centre standardisation of thromboelastography (TEG\u00ae)","volume":"69","author":"Quarterman","year":"2014","journal-title":"Anaesthesia"},{"key":"B29","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s40364-023-00504-6","article-title":"Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer","volume":"11","author":"Ahmadi","year":"2023","journal-title":"biomark Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0482-RA","article-title":"Update on immunohistochemical analysis in breast lesions","volume":"141","author":"Peng","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j3782","article-title":"Indications for anticoagulant and antiplatelet combined therapy","volume":"359","author":"Floyd","year":"2017","journal-title":"BMJ"},{"key":"B32","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.1182\/blood-2019-128170","article-title":"Outcomes of patients receiving direct oral anticoagulants for myeloproliferative neoplasm associated venous thromboembolism","volume":"134","author":"Doyle","year":"2019","journal-title":"Blood"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA-A Cancer J Clin"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1758116","article-title":"Hypercoagulability and thrombosis risk in prostate cancer: The role of thromboelastography","volume":"49","author":"Fainchtein","year":"2022","journal-title":"Semin Thromb Hemost"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2231342","article-title":"The prognosis of breast cancer patients with bone metastasis could be potentially estimated based on blood routine test and biochemical examination at admission","volume":"55","author":"Huang","year":"2023","journal-title":"Ann Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41568-023-00639-6","article-title":"The dynamic role of platelets in cancer progression and their therapeutic implications","volume":"24","author":"Li","year":"2024","journal-title":"Nat Rev Cancer"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.981533","article-title":"Zhao: Combined systemic inflammatory immunity index and prognostic nutritional index scores as a screening marker for sarcopenia in patients with locally advanced gastric cancer","volume":"9","author":"P. a. Ding","year":"2022","journal-title":"Front Nutr"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113714","article-title":"Exposure to melamine and its derivatives in Chinese adults: The cumulative risk assessment and the effect on routine blood parameters","volume":"241","author":"Liu","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1079","article-title":"Monitoring treatment efficacy and resistance in breast cancer patients via circulating tumor DNA genomic profiling","volume":"8","author":"Chen","year":"2020","journal-title":"Mol Genet Genomic Med"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2115616120","article-title":"Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine","volume":"120","author":"Isiksacan","year":"2023","journal-title":"Proc Natl Acad Sci"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657512","article-title":"Venous thromboembolism and gancer: a two-way clinical association","volume":"78","author":"Agnelli","year":"1997","journal-title":"Thromb Haemost"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1177\/1076029617724229","article-title":"Comparison between thromboelastography and conventional coagulation tests in surgical patients with localized prostate cancer","volume":"24","author":"Wang","year":"2017","journal-title":"Clin Appl Thrombosis\/Hemostasis"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39407","article-title":"Thromboelastography in the perioperative period: A literature review","volume":"15","author":"Ramanujam","year":"2023","journal-title":"Cureus"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-5-3","article-title":"Evaluation of the TEG\u00ae platelet mapping\u2122 assay in blood donors","volume":"5","author":"Bochsen","year":"2007","journal-title":"Thromb J"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.05.013","article-title":"Why is everyone so excited about thromboelastrography (TEG)","volume":"436","author":"Karon","year":"2014","journal-title":"Clinica Chimica Acta"},{"key":"B46","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.thromres.2020.01.001","article-title":"Fibrin clot formation under diverse clotting conditions: Comparing turbidimetry and thromboelastography","volume":"187","author":"Zeng","year":"2020","journal-title":"Thromb Res"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.06.019","article-title":"Comparison between thromboelastography and conventional coagulation assays in patients with deep vein thrombosis","volume":"520","author":"Mao","year":"2021","journal-title":"Clinica Chimica Acta"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1753530","article-title":"Thromboelastography-guided therapy enhances patient blood management in cirrhotic patients: A Meta-analysis based on randomized controlled trials","volume":"49","author":"Hartmann","year":"2023","journal-title":"Semin Thromb Hemost"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/j.amjmed.2020.04.029","article-title":"Features of blood clotting on thromboelastography in hospitalized patients with cirrhosis","volume":"133","author":"Shamseddeen","year":"2020","journal-title":"Am J Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2016.08.003","article-title":"Fibrin mechanical properties and their structural origins","author":"Litvinov","year":"2017","journal-title":"Matrix Biol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/jth.12229","article-title":"Fibrin(ogen) and thrombotic disease","volume":"11","author":"Ari\u00ebns","year":"2013","journal-title":"J Thromb Haemostasis"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13067","article-title":"Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients","volume":"13","author":"Moore","year":"2015","journal-title":"J Thromb Haemostasis"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S44469","article-title":"Platelet function tests: a comparative review","volume":"11","author":"Paniccia","year":"2015","journal-title":"Vasc Health Risk Manage"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1617078","article-title":"Depka: Possibilities and limitations of thromboelastometry\/thromboelastography","volume":"26","author":"Lang","year":"2006","journal-title":"Hamostaseologie"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1017\/S1431927621000015","article-title":"The value of detecting pathological changes during clot formation in early disease treatment-na\u00efve breast cancer patients","volume":"27","author":"Goncalves","year":"2021","journal-title":"Microsc Microanalysis"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1692210","article-title":"Clinical application of thromboelastography\/thromboelastometry (TEG\/TEM) in the neonatal population: A narrative review","volume":"45","author":"Konstantinidi","year":"2019","journal-title":"Semin Thromb Hemost"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207794","article-title":"Platelet-rich plasma: New performance understandings and therapeutic considerations in 2020","author":"Everts","year":"2020","journal-title":"In: Int J Mol Sci"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12220","article-title":"Systems biology of coagulation","volume":"11","author":"Diamond","year":"2013","journal-title":"J Thromb Haemostasis"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.308564","article-title":"Fibrinogen and fibrin in hemostasis and thrombosis","volume":"37","author":"Kattula","year":"2017","journal-title":"Arteriosclerosis Thrombosis Vasc Biol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/ijlh.12665","article-title":"Review of D-dimer testing: Good, bad, and ugly","volume":"39","author":"Linkins","year":"2017","journal-title":"Int J Lab Hematol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14060","article-title":"Unveiling the diagnostic enigma of D-dimer testing in cancer patients: Current evidence and areas of application","volume":"53","author":"Gotta","year":"2023","journal-title":"Eur J Clin Invest"},{"key":"B62","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/s13054-022-04167-x","article-title":"Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: Results from a laboratory sub-study of the FEISTY trial","volume":"26","author":"Morrow","year":"2022","journal-title":"Crit Care"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1177\/10760296221077975","article-title":"Thromboelastography for the prevention of perioperative venous thromboembolism in orthopedics","volume":"28","author":"Fan","year":"2022","journal-title":"Clin Appl Thrombosis\/Hemostasis"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1342439\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T04:58:56Z","timestamp":1721192336000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1342439\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":63,"alternative-id":["10.3389\/fonc.2024.1342439"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2024.1342439","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]},"article-number":"1342439"}}