{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:38:17Z","timestamp":1793813897575,"version":"4.6.1"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Penile schwannoma is an uncommonly seen peripheral nerve tumor, of which penile plexiform schwannomas (PS) is extremely rare that has only been reported in several adults. We present a case of penile PS with a similar lesion in inguinal region in a 9-year-old child, which appeared as painless masses and rapidly growing within one year. Penile ultrasonography suggested well-defined lesions with limited vascularity. Both masses presented with low-to-intermediated signal intensity and no definite enhancement in computed tomography. The lesions were completely resected with minimal intraoperative bleeding, and a diagnose of benign PS was confirmed based on H&amp;amp;E staining and positive S-100 expression in immunohistochemistry. There was no evidence of tumor recurrence or metastasis after 6 months of follow-up. Only 6 cases of penile schwannoma in children were recorded, of which 5 were malignant, and none was PS. The malignancy rate of penile schwannoma in children may be overestimated due to delayed diagnose of benign ones. A rapidly growing penile mass with a suspected metastatic lesion in inguinal region could be easily misdiagnosed as malignant. This case report and literature review is expected to assist clinicians in getting a comprehensive understanding of children penile schwannomas and choosing the best management strategy when faced with this rare condition.<\/jats:p>","DOI":"10.3389\/fonc.2024.1356000","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T04:37:45Z","timestamp":1709267865000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Case report and literature review: plexiform schwannoma in the penile and inguinal region in a child"],"prefix":"10.3389","volume":"14","author":[{"given":"Xiaoying","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houqing","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-21-239","article-title":"Penile schwannoma mistaken for hemangioma: a rare case report and literature review","volume":"10","author":"Kim","year":"2021","journal-title":"Transl Androl Urol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.3390\/diagnostics12061463","article-title":"Practical approach to histological diagnosis of peripheral nerve sheath tumors: an update","volume":"12","author":"Magro","year":"2022","journal-title":"Diagnostics"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.10.029","article-title":"Plexiform schwannoma: a clinicopathologic overview with emphasis on the head and neck region","volume":"39","author":"Berg","year":"2008","journal-title":"Hum Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1986.tb02595.x","article-title":"Benign plexiform (multinodular) schwannoma: a rare tumour unassociated with neurofibromatosis","volume":"10","author":"Fletcher","year":"1986","journal-title":"Histopathology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1258\/0956462001915543","article-title":"Not every penile lump is a wart! 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