{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T10:41:31Z","timestamp":1794220891511,"version":"4.8.0"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Cervical cancer (CC) is a significant health problem, especially in low-income countries. Functional studies on the human papillomavirus have generated essential advances in the knowledge of CC. However, many unanswered questions remain. This mini-review discusses the latest results on CC pathogenesis, HPV oncogenesis, and molecular changes identified through next-generation technologies. Interestingly, the percentage of samples with HPV genome integrations correlates with the degree of the cervical lesions, suggesting a role in the development of CC. Also, new functions have been described for the viral oncoproteins E5, E6, and E7, resulting in the acquisition and maintenance of cancer hallmarks, including proliferation, immune response evasion, apoptosis, and genomic instability. Remarkably, E5 oncoprotein affects signaling pathways involved in the expression of interferon-induced genes and EGFR-induced proliferation, while E6 and E7 oncoproteins regulate the DNA damage repair and cell cycle continuity pathways. Furthermore, next-generation technologies provide vast amounts of information, increasing our knowledge of changes in the genome, transcriptome, proteome, metabolome, and epigenome in CC. These studies have identified novel molecular traits associated with disease susceptibility, degree of progression, treatment response, and survival as potential biomarkers and therapeutic targets.<\/jats:p>","DOI":"10.3389\/fonc.2024.1356581","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T04:54:05Z","timestamp":1710824045000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["Molecular aspects of cervical cancer: a pathogenesis update"],"prefix":"10.3389","volume":"14","author":[{"given":"Ver\u00f3nica","family":"Vallejo-Ruiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Guti\u00e9rrez-Xicotencatl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Medina-Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Lizano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"B1","unstructured":"Cancer Today2023"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/IJC.30716","article-title":"Worldwide burden of cancer attributable to HPV by site, country and HPV type","volume":"141","author":"de Martel","year":"2017","journal-title":"Int J Cancer"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE21386","article-title":"Integrated genomic and molecular characterization of cervical cancer","volume":"543","author":"Burk","year":"2017","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/J.PVR.2017.10.003","article-title":"Surgical staging identified false HPV-negative cases in a large series of invasive cervical cancers","volume":"4","author":"Petry","year":"2017","journal-title":"Papillomavirus Res (Amsterdam Netherlands)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1159\/000492658","article-title":"Adaptation of alpha-papillomavirus over millennia","volume":"63","author":"De Oliveira","year":"2019","journal-title":"Acta Cytol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/V7072802","article-title":"Human papillomaviruses; epithelial tropisms, and the development of neoplasia","volume":"7","author":"Egawa","year":"2015","journal-title":"Viruses"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.25259\/CMAS_03_07_2021","article-title":"The Bethesda System for reporting cervical cytology","volume":"19","author":"Pangarkar","year":"2022","journal-title":"Cytojournal"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M705127200","article-title":"Surface-exposed amino acid residues of HPV16 L1 protein mediating interaction with cell surface heparan sulfate","volume":"282","author":"Knappe","year":"2007","journal-title":"J Biol Chem"},{"key":"B9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/J.VIROL.2013.10.034","article-title":"HPV16 infection of HaCaTs is dependent on \u03b24 integrin, and \u03b16 integrin processing","volume":"449","author":"Aksoy","year":"2014","journal-title":"Virology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/S00430-020-00683-1","article-title":"HPV caught in the tetraspanin web","volume":"209","author":"Finke","year":"2020","journal-title":"Med Microbiol Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02143-19","article-title":"Epidermal growth factor receptor and abl2 kinase regulate distinct steps of human papillomavirus 16 endocytosis","volume":"94","author":"Bannach","year":"2020","journal-title":"J Virol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02068-20","article-title":"Human Papillomavirus 16 L2 Recruits both Retromer and Retriever Complexes during Retrograde Trafficking of the Viral Genome to the Cell Nucleus","volume":"95","author":"Pim","year":"2021","journal-title":"J Virol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01499-15","article-title":"A novel PDZ domain interaction mediates the binding between human papillomavirus 16 L2 and sorting nexin 27 and modulates virion trafficking","volume":"89","author":"Pim","year":"2015","journal-title":"J Virol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/J.1462-5822.2010.01515.X","article-title":"Identification of the dynein light chains required for human papillomavirus infection","volume":"13","author":"Schneider","year":"2011","journal-title":"Cell Microbiol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/V9090261","article-title":"Mechanisms by which HPV induces a replication competent environment in differentiating keratinocytes","volume":"9","author":"Moody","year":"2017","journal-title":"Viruses"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-20-0491","article-title":"Cellular functions of HPV16 E5 oncoprotein during oncogenic transformation","volume":"19","author":"Gutierrez-Xicotencatl","year":"2021","journal-title":"Mol Cancer Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/RMV.1822","article-title":"Human papillomavirus molecular biology and disease association","author":"Doorbar","year":"2015","journal-title":"Rev Med Virol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/JNCI\/DJQ001","article-title":"Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2\/3: critical role of duration of infection","volume":"102","author":"Rodriguez","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0B013E3182216FEF","article-title":"Risk factors for persistent cervical intraepithelial neoplasia grades 1 and 2: managed by watchful waiting","volume":"15","author":"Ho","year":"2011","journal-title":"J Low Genit Tract Dis"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/BIOMEDICINES10112965","article-title":"Alteration of the IFN-pathway by human papillomavirus proteins: antiviral immune response evasion mechanism","volume":"10","author":"Castro-Mu\u00f1oz","year":"2022","journal-title":"Biomedicines"},{"key":"B21","doi-asserted-by":"publisher","first-page":"782","DOI":"10.2174\/1389450123666211221160632","article-title":"HPV-mediated cervical cancer: A systematic review on immunological basis, molecular biology, and immune evasion mechanisms","volume":"23","author":"Vanajothi","year":"2022","journal-title":"Curr Drug Targets"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/IJC.31027","article-title":"Immune evasion mechanisms of human papillomavirus: An update","volume":"142","author":"Steinbach","year":"2018","journal-title":"Int J Cancer"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/JNCI\/DJR283","article-title":"Persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer","volume":"103","author":"Chen","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/PATH.4496","article-title":"Pathogenesis of human papillomavirus-associated mucosal disease","volume":"235","author":"Groves","year":"2015","journal-title":"J Pathol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.7150\/JCA.31450","article-title":"The characteristics of HPV integration in cervical intraepithelial cells","volume":"10","author":"Li","year":"2019","journal-title":"J Cancer"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/CARCIN\/BGZ094","article-title":"Risk stratification of cervical lesions using capture sequencing and machine learning method based on HPV and human integrated genomic profiles","volume":"40","author":"Tian","year":"2019","journal-title":"Carcinogenesis"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3085","article-title":"Cervical cancers require the continuous expression of the human papillomavirus type 16 E7 oncoprotein even in the presence of the viral E6 oncoprotein","volume":"72","author":"Jabbar","year":"2012","journal-title":"Cancer Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/CANCERS14184488","article-title":"Direct comparison of HPV16 viral genomic integration, copy loss, and structural variants in oropharyngeal and uterine cervical cancers reveal distinct relationships to E2 disruption and somatic alteration","volume":"14","author":"Schrank","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2754","article-title":"Type-dependent integration frequency of human papillomavirus genomes in cervical lesions","volume":"68","author":"Vinokurova","year":"2008","journal-title":"Cancer Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/IJC.27906","article-title":"Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions","volume":"132","author":"Chaiwongkot","year":"2013","journal-title":"Int J Cancer"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/S41467-022-30190-1","article-title":"Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat Commun"},{"key":"B32","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/J.MEEGID.2015.07.002","article-title":"High-level of viral genomic diversity in cervical cancers: A Brazilian study on human papillomavirus type 16","volume":"34","author":"de Oliveira","year":"2015","journal-title":"Infect Genet Evol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/S12032-023-02085-8","article-title":"HPV-associated cancers: insights into the mechanistic scenario and latest updates","volume":"40","author":"Mukherjee","year":"2023","journal-title":"Med Oncol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/V15020324","article-title":"HPV16 E6 and E7 oncoproteins stimulate the glutamine pathway maintaining cell proliferation in a SNAT1-dependent fashion","volume":"15","author":"Ortiz-Pedraza","year":"2023","journal-title":"Viruses"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARCMED.2014.10.008","article-title":"The role of signaling pathways in cervical cancer and molecular therapeutic targets","volume":"45","author":"Manzo-Merino","year":"2014","journal-title":"Arch Med Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS19092619","article-title":"Papillomaviruses and endocytic trafficking","volume":"19","author":"Siddiqa","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/J.ABB.2023.109716","article-title":"Advances in molecular mechanism of HPV16 E5 oncoprotein carcinogenesis","volume":"745","author":"Chen","year":"2023","journal-title":"Arch Biochem Biophys"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.18632\/ONCOTARGET.21658","article-title":"Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle","volume":"8","author":"Wasson","year":"2017","journal-title":"Oncotarget"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/MEDICINA55070384","article-title":"Key molecular events in cervical cancer development","volume":"55","author":"Balasubramaniam","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/S13046-017-0541-1","article-title":"hrHPV E5 oncoprotein: immune evasion and related immunotherapies","volume":"36","author":"De Freitas","year":"2017","journal-title":"J Exp Clin Cancer Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS20010198","article-title":"HPV-mediated resistance to TNF and TRAIL is characterized by global alterations in apoptosis regulatory factors, dysregulation of death receptors, and induction of ROS\/RNS","volume":"20","author":"Cabe\u00e7a","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/FMICB.2019.02483","article-title":"Ubiquitination of the HPV oncoprotein E6 is critical for E6\/E6AP-mediated p53 degradation","volume":"10","author":"Li","year":"2019","journal-title":"Front Microbiol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01875-21","article-title":"High-risk mucosal human papillomavirus 16 (HPV16) E6 protein and cutaneous HPV5 and HPV8 E6 proteins employ distinct strategies to interfere with interferon regulatory factor 3-mediated beta interferon expression","volume":"96","author":"Poirson","year":"2022","journal-title":"J Virol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3892\/OL.2020.11625","article-title":"Promoter methylation of tumor suppressor genes induced by human papillomavirus in cervical cancer","volume":"20","author":"Yanatatsaneejit","year":"2020","journal-title":"Oncol Lett"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.4049\/JIMMUNOL.178.5.3186","article-title":"TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16","volume":"178","author":"Hasan","year":"2007","journal-title":"J Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.18632\/ONCOTARGET.22036","article-title":"Direct HPV E6\/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00114-11","article-title":"E6 and E7 from human papillomavirus type 16 cooperate to target the PDZ protein Na\/H exchange regulatory factor 1","volume":"85","author":"Accardi","year":"2011","journal-title":"J Virol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/V7072785","article-title":"The human papillomavirus E6 PDZ binding motif: from life cycle to Malignancy","volume":"7","author":"Ganti","year":"2015","journal-title":"Viruses"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PPAT.1007575","article-title":"E6 proteins from high-risk HPV, low-risk HPV, and animal papillomaviruses activate the Wnt\/\u03b2-catenin pathway through E6AP-dependent degradation of NHERF1","volume":"15","author":"Drews","year":"2019","journal-title":"PloS Pathog"},{"key":"B50","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/J.VIRUSRES.2016.10.017","article-title":"The human papillomavirus E7 oncoprotein as a regulator of transcription","volume":"231","author":"Songock","year":"2017","journal-title":"Virus Res"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01360-19","article-title":"Genome-wide transcriptome analysis of human papillomavirus 16-infected primary keratinocytes reveals subtle perturbations mostly due to E7 protein expression","volume":"94","author":"Bienkowska-Haba","year":"2020","journal-title":"J Virol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.7150\/JCA.45871","article-title":"MicroRNA-154-5p regulates the HPV16 E7-pRb pathway in Cervical Carcinogenesis by targeting CUL2","volume":"11","author":"Zhao","year":"2020","journal-title":"J Cancer"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.19.10566-10574.2003","article-title":"Direct activation of cyclin-dependent kinase 2 by human papillomavirus E7","volume":"77","author":"He","year":"2003","journal-title":"J Virol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1906102116","article-title":"Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response","volume":"116","author":"Sitz","year":"2019","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/S41419-020-03244-9","article-title":"HPV E7-mediated NCAPH ectopic expression regulates the carcinogenesis of cervical carcinoma via PI3K\/AKT\/SGK pathway","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2626","article-title":"Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases","volume":"71","author":"Bodily","year":"2011","journal-title":"Cancer Res"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/MBIO.02323-18","article-title":"Repression of human papillomavirus oncogene expression under hypoxia is mediated by PI3K\/mTORC2\/AKT signaling","volume":"10","author":"Bossler","year":"2019","journal-title":"MBio"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/SREP16865","article-title":"Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity","volume":"5","author":"Mitra","year":"2015","journal-title":"Sci Rep"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1055\/A-2044-0162","article-title":"Dysbiotic co-factors in cervical cancer. How the microbiome influences the development of cervical intraepithelial neoplasia (CIN)","volume":"83","author":"Finzer","year":"2023","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELREP.2023.112508","article-title":"Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway","volume":"42","author":"Miyauchi","year":"2023","journal-title":"Cell Rep"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01582-19","article-title":"Human papillomavirus 16 E5 inhibits interferon signaling and supports episomal viral maintenance","volume":"94","author":"Scott","year":"2020","journal-title":"J Virol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE16481","article-title":"Structure of the E6\/E6AP\/p53 complex required for HPV-mediated degradation of p53","volume":"529","author":"Martinez-Zapien","year":"2016","journal-title":"Nature"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2022.900856","article-title":"HPV16 E6-Activated OCT4 Promotes Cervical Cancer Progression by Suppressing p53 Expression via Co-Repressor NCOR1","volume":"12","author":"Shu","year":"2022","journal-title":"Front Oncol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/J.CANLET.2019.10.046","article-title":"A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth","volume":"470","author":"Celegato","year":"2020","journal-title":"Cancer Lett"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2021.677867","article-title":"Novel affibody molecules targeting the HPV16 E6 oncoprotein inhibited the proliferation of cervical cancer cells","volume":"9","author":"Zhu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3390\/PATHOGENS11091027","article-title":"Do or die: HPV E5, E6 and E7 in cell death evasion","volume":"11","author":"Skelin","year":"2022","journal-title":"Pathog (Basel Switzerland)"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.7150\/THNO.78091","article-title":"Human papillomavirus E6\/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair","volume":"13","author":"Bruyere","year":"2023","journal-title":"Theranostics"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01181-21","article-title":"Role of E6 in maintaining the basal cell reservoir during productive papillomavirus infection","volume":"96","author":"Saunders-Wood","year":"2022","journal-title":"J Virol"},{"key":"B69","first-page":"684","article-title":"HPV18 E7 induces the over-transcription of eIF4E gene in cervical cancer","volume":"18","author":"Pang","year":"2015","journal-title":"Iran J Basic Med Sci"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/J.VIRUSRES.2016.11.006","article-title":"Modulation of the DNA damage response during the life cycle of human papillomaviruses","volume":"231","author":"Anacker","year":"2017","journal-title":"Virus Res"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1093\/HMG\/DDAD043","article-title":"GWAS meta-analyses clarify the genetics of cervical phenotypes and inform risk stratification for cervical cancer","volume":"32","author":"Koel","year":"2023","journal-title":"Hum Mol Genet"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE12881","article-title":"Landscape of genomic alterations in cervical carcinomas","volume":"506","author":"Ojesina","year":"2014","journal-title":"Nature"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/JCM9113668","article-title":"MicroRNA-based fingerprinting of cervical lesions and cancer","volume":"9","author":"Pisarska","year":"2020","journal-title":"J Clin Med"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1186\/S12885-021-08412-4","article-title":"Bioinformatics analysis of differentially expressed genes and pathways in the development of cervical cancer","volume":"21","author":"Wu","year":"2021","journal-title":"BMC Cancer"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/FMED.2022.759928","article-title":"Novel insight of circRNAs in cervical cancer: potential biomarkers and therapeutic target","volume":"9","author":"Wu","year":"2022","journal-title":"Front Med"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24076032","article-title":"Identification of mir-182-3p\/FLI-1 axis as a key signaling in immune response in cervical cancer: A comprehensive bioinformatic analysis","volume":"24","author":"Salmer\u00f3n-B\u00e1rcenas","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1186\/S12885-023-10636-5","article-title":"The hsa_circ_0000276-ceRNA regulatory network and immune infiltration in cervical cancer","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Cancer"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/J.COMPBIOMED.2023.106943","article-title":"Comprehensive analysis of lncRNA-mRNA co-expression networks in HPV-driven cervical cancer reveals the pivotal function of LINC00511-PGK1 in tumorigenesis","volume":"159","author":"Xin","year":"2023","journal-title":"Comput Biol Med"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/FGENE.2023.1142938","article-title":"Construction of a prognostic model based on eight ubiquitination-related genes via machine learning and potential therapeutics analysis for cervical cancer","volume":"14","author":"Hao","year":"2023","journal-title":"Front Genet"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/FGENE.2022.933798","article-title":"A novel ten-gene prognostic signature for cervical cancer based on CD79B-related immunomodulators","volume":"13","author":"Pu","year":"2022","journal-title":"Front Genet"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.7717\/PEERJ.12081","article-title":"Hallmarks of glycogene expression and glycosylation pathways in squamous and adenocarcinoma cervical cancer","volume":"9","author":"Martinez-Morales","year":"2021","journal-title":"PeerJ"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12709","article-title":"HPV-related methylation-based reclassification and risk stratification of cervical cancer","volume":"14","author":"Yang","year":"2020","journal-title":"Mol Oncol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/S13148-023-01537-2","article-title":"DNA methylation as a triage marker for colposcopy referral in HPV-based cervical cancer screening: a systematic review and meta-analysis","volume":"15","author":"Salta","year":"2023","journal-title":"Clin Epigenet"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2023.1213285","article-title":"HPV16 E6\/E7-based mRNA vaccine is therapeutic in mice bearing aggressive HPV-positive lesions","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Immunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/J.TRANON.2019.06.003","article-title":"Monoclonal antibodies against human papillomavirus E6 and E7 oncoproteins inhibit tumor growth in experimental cervical cancer","volume":"12","author":"Jiang","year":"2019","journal-title":"Transl Oncol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1186\/S13046-021-01841-W","article-title":"Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors","volume":"40","author":"Paolini","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANTIVIRAL.2020.104794","article-title":"In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6\/E7 mRNAs\u2019 cleavage by CRISPR\/Cas13a system","volume":"178","author":"Chen","year":"2020","journal-title":"Antiviral Res"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3892\/IJMM.2020.4789","article-title":"Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes","volume":"47","author":"Sun","year":"2021","journal-title":"Int J Mol Med"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1007\/S11864-023-01050-X","article-title":"Immunotherapy in HPV-related oropharyngeal cancers","volume":"24","author":"Roof","year":"2023","journal-title":"Curr Treat Options Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1356581\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T04:54:08Z","timestamp":1710824048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1356581\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":89,"alternative-id":["10.3389\/fonc.2024.1356581"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2024.1356581","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,19]]},"article-number":"1356581"}}