{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:54:27Z","timestamp":1793231667127,"version":"4.5.0"},"reference-count":174,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Cancer treatment is associated with long lasting cognitive impairment in cancer survivors. This cognitive impairment is often termed cancer related cognitive impairment (CRCI). Cancer survivors treated for tumors outside the central nervous system are increasingly diagnosed with CRCI. The development of strategies to mitigate the negative effects of cancer treatment on the brain are crucial. Although neuroimaging research has proposed several candidate mechanisms, the pathogenic underpinnings of CRCI remain uncertain. As such, preventative and treatment strategies have not been identified. To fill these gaps, animal models play a vital role in isolating underlying contributing mechanisms that promote CRCI and in testing new therapeutic approaches.<\/jats:p>","DOI":"10.3389\/fonc.2024.1387251","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T04:33:22Z","timestamp":1713846802000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":58,"title":["Cancer related cognitive impairment: a downside of cancer treatment"],"prefix":"10.3389","volume":"14","author":[{"given":"Kimberly","family":"Demos-Davies","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis","family":"Seelig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"B1","volume-title":"Cancer Treatment & Survivorship Facts & Figures\u00a02022-2024","year":"2022"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21258","article-title":"Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer-related cognitive impairment in adults","volume":"65","author":"Wefel","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.3390\/cancers15041215","article-title":"A systematic review on the potential acceleration of neurocognitive aging in older cancer survivors","volume":"15","author":"Kerstens","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4198","DOI":"10.3390\/cancers13164198","article-title":"Neuroinflammation and its association with cognition, neuronal markers and peripheral inflammation after chemotherapy for breast cancer","volume":"13","author":"Schroyen","year":"2021","journal-title":"Cancers"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.1067298","article-title":"Cancer treatment induces neuroinflammation and behavioral deficits in mice","volume":"16","author":"Demos-Davies","year":"2022","journal-title":"Front Behav Neurosci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2021.02.003","article-title":"Microglia in cancer therapy-related cognitive impairment","volume":"44","author":"Gibson","year":"2021","journal-title":"Trends Neurosci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163233","article-title":"Central nervous system injury \u2013 A newly observed bystander effect of radiation","volume":"11","author":"Feiock","year":"2016","journal-title":"PloS One"},{"key":"B8","first-page":"36","article-title":"Cognitive impairment associated with cancer: A brief review","volume":"15","author":"Pendergrass","year":"2018","journal-title":"Innov Clin Neurosci"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2011.03.014","article-title":"An update on cancer- and chemotherapy-related cognitive dysfunction: current status","volume":"38","author":"Janelsins","year":"2011","journal-title":"Semin Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"103822","DOI":"10.1016\/j.critrevonc.2022.103822","article-title":"Blood-based biomarkers of cancer-related cognitive impairment in non-central nervous system cancer: A scoping review","volume":"180","author":"Oppegaard","year":"2022","journal-title":"Crit Rev Oncol Hematol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1200\/EDBK_201179","article-title":"Cognitive changes in cancer survivors","volume":"38","author":"Hardy","year":"2018","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"B12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/brainsci14010022","article-title":"The distant molecular effects on the brain by cancer treatment","volume":"14","author":"Demos-Davies","year":"2023","journal-title":"Brain Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.3390\/cancers11050687","article-title":"Pretreatment cancer-related cognitive impairment-mechanisms and outlook","volume":"11","author":"Olson","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5847","article-title":"Psychological distress is involved in CRCI in breast cancer survivors via mediating cytokine levels","volume":"12","author":"Pang","year":"2023","journal-title":"Cancer Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz410","article-title":"Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors","volume":"30","author":"Lange","year":"2019","journal-title":"Ann Oncol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70294-1","article-title":"International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer","volume":"12","author":"Wefel","year":"2011","journal-title":"Lancet Oncol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000578","article-title":"Emerging mechanistic underpinnings and therapeutic targets for chemotherapy-related cognitive impairment","volume":"31","author":"Gibson","year":"2019","journal-title":"Curr Opin Oncol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e3039","DOI":"10.1002\/brb3.3039","article-title":"Altered resting-state hippocampal functional connectivity in breast cancer survivors with chemotherapy-induced amenorrhea","volume":"13","author":"Zhuang","year":"2023","journal-title":"Brain Behav"},{"key":"B19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1742-2094-1-14","article-title":"Microglia and neuroinflammation: a pathological perspective","volume":"1","author":"Streit","year":"2004","journal-title":"J Neuroinflammation"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24192","article-title":"Cognitive functioning in breast cancer survivors: a controlled comparison","volume":"115","author":"Jim","year":"2009","journal-title":"Cancer"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2004.10.004","article-title":"The effects of adjuvant chemotherapy on cognition in women with breast cancer\u2014preliminary results of an observational longitudinal study","volume":"14","author":"Shilling","year":"2005","journal-title":"Breast (Edinburgh)"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.02.007","article-title":"Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment (\"chemobrain\"), a condition that significantly impairs the quality of life of many cancer survivors","volume":"1865","author":"Ren","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01195","article-title":"Neuroimmunology of behavioral comorbidities associated with cancer and cancer treatments","volume":"9","author":"Santos","year":"2018","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41571-023-00776-9","article-title":"Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship","volume":"20","author":"Lustberg","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.04.021","article-title":"Either called \"chemobrain\" or \"chemofog,\" the long-term chemotherapy-induced cognitive decline in cancer survivors is real","volume":"41","author":"Argyriou","year":"2011","journal-title":"J Pain Symptom Manage"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.05.001","article-title":"Chemotherapy-induced cognitive impairments: A systematic review of the animal literature","volume":"102","author":"Matsos","year":"2019","journal-title":"Neurosci Biobehav Rev"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2854","article-title":"The blood-brain barrier and cancer: transporters, treatment, and Trojan horses","volume":"13","author":"Deeken","year":"2007","journal-title":"Clin Cancer Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"13801","DOI":"10.1038\/s41598-018-32257-w","article-title":"Diminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"key":"B29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jneuroim.2017.10.005","article-title":"Associations between inflammatory markers and cognitive function in breast cancer patients receiving chemotherapy","volume":"314","author":"Williams","year":"2018","journal-title":"J Neuroimmunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"8896","DOI":"10.3390\/ijerph17238896","article-title":"Study of chemotherapy-induced cognitive impairment in women with breast cancer","volume":"17","author":"Rodr\u00edguez Mart\u00edn","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv206","article-title":"Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study","volume":"26","author":"Cheung","year":"2015","journal-title":"Ann Oncol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1097-0142","article-title":"Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma","volume":"85","author":"Schagen","year":"1999","journal-title":"Cancer"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.3.210","article-title":"Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy","volume":"90","author":"van Dam","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/pon.2960040108","article-title":"Neuropsychological assessment of cognitive functioning following chemotherapy for breast cancer","volume":"4","author":"Wieneke","year":"1995","journal-title":"Psycho-oncology"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.6550","article-title":"Fatigue, menopausal symptoms, and cognitive function in women after adjuvant chemotherapy for breast cancer: 1- and 2-year follow-up of a prospective controlled study","volume":"23","author":"Fan","year":"2005","journal-title":"J Clin Oncol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1210","article-title":"The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study","volume":"17","author":"Stewart","year":"2008","journal-title":"Psycho-oncology (Chichester England)"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.075","article-title":"Quality of life in good prognosis patients with metastatic germ cell cancer: a prospective study of the European Organization for Research and Treatment of Cancer Genitourinary Group\/Medical Research Council Testicular Cancer Study Group (30941\/TE20)","volume":"21","author":"Foss\u00e5","year":"2003","journal-title":"J Clin Oncol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3453","article-title":"A prospective study of cognitive function in men with non-seminomatous germ cell tumors","volume":"23","author":"Wefel","year":"2014","journal-title":"Psychooncology"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx085","article-title":"Changes in brain structural networks and cognitive functions in testicular cancer patients receiving cisplatin-based chemotherapy","volume":"109","author":"Amidi","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2010.12.004","article-title":"Self-reported cognitive problems in testicular cancer patients: relation to neuropsychological performance, fatigue, and psychological distress","volume":"70","author":"Skaali","year":"2011","journal-title":"J Psychosom Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15448","article-title":"Cognitive impairment in hodgkin lymphoma survivors","volume":"182","author":"Trachtenberg","year":"2018","journal-title":"Br J Haematol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"137082","DOI":"10.1016\/j.neulet.2023.137082","article-title":"Cognitive impairment associated with Hodgkin's lymphoma and chemotherapy","volume":"797","author":"Fayette","year":"2023","journal-title":"Neurosci Lett"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.915546","article-title":"Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to determine cognitive impairments after treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone or rituximab and bendamustine","volume":"56","author":"Zimmer","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"B44","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1093\/jnci\/djab133","article-title":"Longitudinal changes in cognitive function in a nationwide cohort study of patients with lymphoma treated with chemotherapy","volume":"114","author":"Janelsins","year":"2022","journal-title":"J Natl Cancer Inst"},{"key":"B45","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.ijrobp.2010.06.037","article-title":"One-year longitudinal study of fatigue, cognitive functions, and quality of life after adjuvant radiotherapy for breast cancer","volume":"81","author":"Noal","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.174","article-title":"Association between adjuvant regional radiotherapy and cognitive function in breast cancer patients treated with conservation therapy","volume":"3","author":"Shibayama","year":"2014","journal-title":"Cancer Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21482","article-title":"Cognitive functioning after adjuvant chemotherapy and\/or radiotherapy for early-stage breast carcinoma","volume":"104","author":"Donovan","year":"2005","journal-title":"Cancer"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.0722001","article-title":"Self-reported cognitive impairment in patients with cancer","volume":"3","author":"Kohli","year":"2007","journal-title":"J Oncol Pract"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2018-000397","article-title":"Impact of abiraterone acetate plus prednisone or enzalutamide on fatigue and cognition in patients with metastatic castration-resistant prostate cancer: initial results from the observational AQUARiUS study","volume":"3","author":"Thiery-Vuillemin","year":"2018","journal-title":"ESMO Open"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/pon.964","article-title":"Cognitive impairment associated with adjuvant therapy in breast cancer","volume":"15","author":"Bender","year":"2006","journal-title":"Psycho-oncology (Chichester England)"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.16.2.185","article-title":"Cognitive dysfunction and depression during treatment with interferon-alpha and chemotherapy","volume":"16","author":"Scheibel","year":"2004","journal-title":"J neuropsychiatry Clin neurosciences"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05168-3","article-title":"Health-related quality of life, emotional burden, and neurocognitive function in the first generation of metastatic melanoma survivors treated with pembrolizumab: a longitudinal pilot study","volume":"28","author":"Rogiers","year":"2020","journal-title":"Supportive Care cancer"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2192480","article-title":"Neurocognitive function, psychosocial outcome, and health-related quality of life of the first-generation metastatic melanoma survivors treated with ipilimumab","volume":"2020","author":"Rogiers","year":"2020","journal-title":"J Immunol Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76055-9","article-title":"Description of neurotoxicity in a series of patients treated with CAR T-cell therapy","volume":"10","author":"Belin","year":"2020","journal-title":"Sci Rep"},{"key":"B55","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.bbmt.2019.09.037","article-title":"Patient-reported neuropsychiatric outcomes of long-term survivors after chimeric antigen receptor T cell therapy","volume":"26","author":"Ruark","year":"2020","journal-title":"Biol Blood marrow transplantation"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.03.023","article-title":"Change in neurocognitive performance among patients with non-hodgkin lymphoma in the first year after chimeric antigen receptor T cell therapy","volume":"28","author":"Hoogland","year":"2022","journal-title":"Transplant Cell Ther"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.3390\/cancers15051615","article-title":"First-line immunotherapy with check-point inhibitors: prospective assessment of cognitive function","volume":"15","author":"Myers","year":"2023","journal-title":"Cancers"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acp060","article-title":"Course of cognitive decline in hematopoietic stem cell transplantation: a within-subjects design","volume":"24","author":"Friedman","year":"2009","journal-title":"Arch Clin Neuropsychol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01481-w","article-title":"Impact of patient and clinical characteristics on cognitive changes after allogeneic hematopoietic stem cell transplantation","volume":"56","author":"Nakamura","year":"2021","journal-title":"Bone marrow Transplant (Basingstoke)"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705663","article-title":"Cognitive function in the acute course of allogeneic hematopoietic stem cell transplantation for hematological Malignancies","volume":"39","author":"Schulz-Kindermann","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28323","article-title":"Acute cognitive impairment in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplant","volume":"119","author":"Jones","year":"2013","journal-title":"Cancer"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3159","article-title":"Cognitive functioning in allogeneic hematopoietic stem cell transplantation recipients and its medical correlates: a prospective multicenter study","volume":"22","author":"Scherwath","year":"2013","journal-title":"Psychooncology"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.06.005","article-title":"Case-referent comparison of cognitive functions in patients receiving haematopoietic stem-cell transplantation for haematological Malignancies: Two-year follow-up results","volume":"43","author":"Harder","year":"2007","journal-title":"Eur J Cancer (1990)"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.05.017","article-title":"Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors","author":"Kesler","year":"2013","journal-title":"Brain Behav Immun"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.0189","article-title":"Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy","volume":"30","author":"Koppelmans","year":"2012","journal-title":"J Clin Oncol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1176\/appi.neuropsych.22.1.48","article-title":"Neuropsychological outcomes of older breast cancer survivors: cognitive features ten or more years after chemotherapy","volume":"22","author":"Yamada","year":"2010","journal-title":"J\u00a0Neuropsychiatry Clin Neurosci"},{"key":"B67","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s13058-018-1062-3","article-title":"Inflammation markers and cognitive performance in breast cancer survivors 20 years after completion of chemotherapy: a cohort study","volume":"20","author":"van der Willik","year":"2018","journal-title":"Breast Cancer Res"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.2.485","article-title":"Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma","volume":"20","author":"Ahles","year":"2002","journal-title":"J Clin Oncol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1080\/02841860701518058","article-title":"Cognitive complaints and cognitive impairment following BEP chemotherapy in patients with testicular cancer","volume":"47","author":"Schagen","year":"2008","journal-title":"Acta Oncol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1017\/S1355617709090316","article-title":"Long-term cognitive function following chemotherapy in patients with testicular cancer","volume":"15","author":"Pedersen","year":"2009","journal-title":"J Int Neuropsychol Society"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0457","article-title":"Long-term cognitive functioning in testicular germ-cell tumor survivors","volume":"23","author":"Chovanec","year":"2018","journal-title":"Oncologist"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2011.602113","article-title":"Testicular-cancer survivors experience compromised language following chemotherapy: findings in a Swedish population-based study 3-26 years after treatment","volume":"51","author":"Skoogh","year":"2012","journal-title":"Acta Oncol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22942","article-title":"Lower cognitive performance and white matter changes in testicular cancer survivors 10 years after chemotherapy","volume":"36","author":"Stouten-Kemperman","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2663-3","article-title":"Cognitive impairment in testicular cancer survivors 2 to 7 years after treatment","volume":"23","author":"Amidi","year":"2015","journal-title":"Support Care Cancer"},{"key":"B75","doi-asserted-by":"publisher","first-page":"5675","DOI":"10.3390\/cancers13225675","article-title":"Cognitive impairment in long-term survivors of testicular cancer more than 20 years after treatment","volume":"13","author":"Stelwagen","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26432","article-title":"Cognitive functioning after cancer treatment: a 3-year longitudinal comparison of breast cancer survivors treated with chemotherapy or radiation and noncancer controls","volume":"118","author":"Phillips","year":"2012","journal-title":"Cancer"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1080\/13803390490510905","article-title":"Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen","volume":"26","author":"Castellon","year":"2004","journal-title":"J Clin Exp Neuropsychol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.2270","article-title":"Cognitive functioning after hematopoietic cell transplantation for hematologic Malignancy: results from a prospective longitudinal study","volume":"36","author":"Sharafeldin","year":"2018","journal-title":"J Clin Oncol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.9119","article-title":"Prospective neurocognitive function over 5 years after allogeneic hematopoietic cell transplantation for cancer survivors compared with matched controls at 5 years","volume":"29","author":"Syrjala","year":"2011","journal-title":"J Clin Oncol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10549-023-07005-y","article-title":"Advances of neuroimaging in chemotherapy related cognitive impairment (CRCI) of patients with breast cancer","volume":"201","author":"Yao","year":"2023","journal-title":"Breast Cancer Res Treat"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2022-0086","article-title":"Anthracycline chemotherapy, vascular dysfunction and cognitive impairment: burgeoning topics and future directions","volume":"19","author":"Maurer","year":"2023","journal-title":"Future Cardiol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00262-021-03013-3","article-title":"Chemotherapy: a double-edged sword in cancer treatment","volume":"71","author":"Behranvand","year":"2022","journal-title":"Cancer immunology Immunother"},{"key":"B83","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.ctrv.2012.11.001","article-title":"A meta-analysis of the effects of chemotherapy on cognition in patients with cancer","volume":"39","author":"Hodgson","year":"2013","journal-title":"Cancer Treat Rev"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9380-z","article-title":"Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy","volume":"103","author":"Silverman","year":"2007","journal-title":"Breast Cancer Res Treat"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21422","article-title":"Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: converging results from multimodal magnetic resonance imaging","volume":"33","author":"de Ruiter","year":"2012","journal-title":"Hum Brain Mapp"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1088-4","article-title":"Gray matter reduction associated with systemic chemotherapy for breast cancer: a prospective MRI study","volume":"123","author":"McDonald","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.09.006","article-title":"Neurobiological basis of chemotherapy-induced cognitive impairment: A review of rodent research","volume":"35","author":"Seigers","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60488-8","article-title":"Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials","volume":"383","author":"McGale","year":"2014","journal-title":"Lancet"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2014.09.018","article-title":"Radiotherapy before and after radical prostatectomy for high-risk and locally advanced prostate cancer","volume":"33","author":"Perez","year":"2015","journal-title":"Urol Oncol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.21037\/tcr","article-title":"Radiotherapy and radiochemotherapy increase serum levels of pro-inflammatory interleukin-6 and C-reactive protein in patients with head and neck cancers","volume":"7","author":"Kiprian","year":"2018","journal-title":"Trans Cancer Res"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1667\/RR3031.1","article-title":"Cytokines in radiobiological responses: A review","volume":"178","author":"Schaue","year":"2012","journal-title":"Radiat Res"},{"key":"B92","doi-asserted-by":"publisher","first-page":"19002","DOI":"10.1038\/s41598-020-75812-0","article-title":"Evaluation of cytokine expression and circulating immune cell subsets as potential parameters of acute radiation toxicity in prostate cancer patients","volume":"10","author":"Stanojkovi\u0107","year":"2020","journal-title":"Sci Rep"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2022.0287","article-title":"Chrysin attenuates oxidative stress to alleviate sevoflurane-induced cognitive impairments in aged rats","volume":"20","author":"Chen","year":"2023","journal-title":"Psychiatry Invest"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-071726","article-title":"Cognitive impairment after cancer treatment: mechanisms, clinical characterization, and management","volume":"380","author":"Fleming","year":"2023","journal-title":"BMJ"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1379","article-title":"Cognitive effects of chemotherapy in post-menopausal breast cancer patients 1 year after treatment","volume":"18","author":"Collins","year":"2009","journal-title":"Psychooncology"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006426132338","article-title":"Preliminary assessment of cognitive function in breast cancer patients treated with tamoxifen","volume":"64","author":"Paganini-Hill","year":"2000","journal-title":"Breast Cancer Res Treat"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13867","article-title":"Neurocognitive impairment after hematopoietic stem cell transplant for hematologic Malignancies: phenotype and mechanisms","volume":"26","author":"Harrison","year":"2021","journal-title":"oncologist (Dayton Ohio)"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-021-03695-w","article-title":"Neurotoxicities associated with immune checkpoint inhibitor therapy","volume":"152","author":"Duong","year":"2021","journal-title":"J neuro-oncology"},{"key":"B99","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00213-014-3636-9","article-title":"Cognitive impact of cytotoxic agents in mice","volume":"232","author":"Seigers","year":"2015","journal-title":"Psychopharmacol (Berl)"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2000","article-title":"Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy","volume":"18","author":"Christie","year":"2012","journal-title":"Clin Cancer Res"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2015.04.010","article-title":"Pre-treatment effects of peripheral tumors on brain and behavior: neuroinflammatory mechanisms in humans and rodents","volume":"49","author":"Schrepf","year":"2015","journal-title":"Brain Behav Immun"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.v8i6","article-title":"Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model","volume":"8","author":"McGinnis","year":"2017","journal-title":"Oncotarget"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.12.012","article-title":"Is basic research providing answers if adjuvant anti-estrogen treatment of breast cancer can induce cognitive impairment","volume":"93","author":"Buwalda","year":"2013","journal-title":"Life Sci (1973)"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1139\/y11-132","article-title":"Profound destructive effects of adolescent exposure to vincristine accompanied with some sex differences in motor and memory performance","volume":"90","author":"Shabani","year":"2012","journal-title":"Can J Physiol Pharmacol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2012.08.004","article-title":"Walnut consumption protects rats against cisplatin-induced neurotoxicity","volume":"33","author":"Shabani","year":"2012","journal-title":"Neurotoxicology (Park For South)"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.12.028","article-title":"Memory loss in chemotherapy-treated rats is exacerbated in high-interference conditions and related to suppression of hippocampal neurogenesis","volume":"281","author":"Winocur","year":"2015","journal-title":"Behav Brain Res"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3394-0","article-title":"Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats","volume":"231","author":"Winocur","year":"2014","journal-title":"Psychopharmacology"},{"key":"B108","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.pbb.2006.07.010","article-title":"The effects of the anti-cancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice","volume":"85","author":"Winocur","year":"2006","journal-title":"Pharmacology Biochem behavior"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12032","article-title":"Cytoarchitectural, behavioural and neurophysiological dysfunctions in the BCNU-treated rat model of cortical dysplasia","volume":"37","author":"Inverardi","year":"2013","journal-title":"Eur J Neurosci"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.06.013","article-title":"A clinically relevant dose of cyclophosphamide chemotherapy impairs memory performance on the delayed spatial alternation task that is sustained over time as mice age","volume":"56","author":"Janelsins","year":"2016","journal-title":"Neurotoxicology (Park For South)"},{"key":"B111","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bbr.2016.07.043","article-title":"Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer","volume":"315","author":"Rendeiro","year":"2016","journal-title":"Behav Brain Res"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2122-2","article-title":"Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy","volume":"215","author":"Lyons","year":"2011","journal-title":"Psychopharmacology"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.08.006","article-title":"Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist","volume":"225","author":"Vijayanathan","year":"2011","journal-title":"Behav Brain Res"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.11.017","article-title":"Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil","volume":"208","author":"Elbeltagy","year":"2010","journal-title":"Behav Brain Res"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030010","article-title":"Fluoxetine counteracts the cognitive and cellular effects of 5-Fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery","volume":"7","author":"Lyons","year":"2012","journal-title":"PloS One"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06325.x","article-title":"5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus","volume":"28","author":"Mustafa","year":"2008","journal-title":"Eur J Neurosci"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2237","article-title":"Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction","volume":"75","author":"Acharya","year":"2015","journal-title":"Cancer Res (Chicago Ill)"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.04.044","article-title":"Long-term cognitive dysfunction in the rat following docetaxel treatment is ameliorated by the phosphodiesterase-4 inhibitor, rolipram","volume":"290","author":"Callaghan","year":"2015","journal-title":"Behav Brain Res"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.04.038","article-title":"The long-term impact of oxaliplatin chemotherapy on rodent cognition and peripheral neuropathy","volume":"291","author":"Fardell","year":"2015","journal-title":"Behav Brain Res"},{"key":"B120","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.lfs.2013.05.006","article-title":"The short and long term effects of docetaxel chemotherapy on rodent object recognition and spatial reference memory","volume":"93","author":"Fardell","year":"2013","journal-title":"Life Sci (1973)"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.11.046","article-title":"Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats","volume":"102","author":"Lomeli","year":"2017","journal-title":"Free Radical Biol Med"},{"key":"B122","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bbr.2010.01.016","article-title":"The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice","volume":"209","author":"Mondie","year":"2010","journal-title":"Behav Brain Res"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.06.007","article-title":"Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: Possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation","volume":"292","author":"Kitamura","year":"2015","journal-title":"Behav Brain Res"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-016-1338-z","article-title":"Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats","volume":"390","author":"Kitamura","year":"2017","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.06.028","article-title":"Doxorubicin and cyclophosphamide induce cognitive dysfunction and activate the ERK and AKT signaling pathways","volume":"292","author":"Salas-Ramirez","year":"2015","journal-title":"Behav Brain Res"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3161-0","article-title":"Post-treatment with cotinine improved memory and decreased depressive-like behavior after chemotherapy in rats","volume":"78","author":"Iarkov","year":"2016","journal-title":"Cancer chemotherapy Pharmacol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2466-2","article-title":"Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity","volume":"220","author":"Fardell","year":"2012","journal-title":"Psychopharmacology"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0060","article-title":"The effects of chemotherapy on cognitive function in a mouse model: A prospective study","volume":"18","author":"Winocur","year":"2012","journal-title":"Clin Cancer Res"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12007","article-title":"Chemotherapy disrupts learning, neurogenesis and theta activity in the adult brain","volume":"36","author":"Nokia","year":"2012","journal-title":"Eur J Neurosci"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1139\/y02-135","article-title":"Hippocampal brain amines in methotrexate-induced learning and memory deficit","volume":"80","author":"Madhyastha","year":"2002","journal-title":"Can J Physiol Pharmacol"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.09.030","article-title":"Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo","volume":"48","author":"Song","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.02.025","article-title":"Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats","volume":"201","author":"Seigers","year":"2009","journal-title":"Behav Brain Res"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2012.07.003","article-title":"Acute treatment with methotrexate induces hippocampal dysfunction in a mouse model of breast cancer","volume":"89","author":"Yang","year":"2012","journal-title":"Brain Res bulletin"},{"key":"B134","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/bcpt.12629","article-title":"Apoptotic process induced by oxaliplatin in rat hippocampus causes memory impairment","volume":"120","author":"Bianchi","year":"2017","journal-title":"Basic Clin Pharmacol toxicology"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.05.087","article-title":"Compound K is able to ameliorate the impaired cognitive function and hippocampal neurogenesis following chemotherapy treatment","volume":"436","author":"Hou","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6945415","article-title":"PET evidence of the effect of donepezil on cognitive performance in an animal model of chemobrain","volume":"2016","author":"Lim","year":"2016","journal-title":"BioMed Res Int"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-008-9100-y","article-title":"Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats","volume":"23","author":"Konat","year":"2008","journal-title":"Metab Brain disease"},{"key":"B138","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4161\/oxim.2.1.7901","article-title":"Metallothionein induction reduces caspase-3 activity and TNFalpha levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats","volume":"2","author":"Helal","year":"2009","journal-title":"Oxid Med Cell Longev"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3764","article-title":"Effects of early chemotherapeutic treatment on learning in adolescent mice: implications for cognitive impairment and remediation in childhood cancer survivors","volume":"19","author":"Bisen-Hersh","year":"2013","journal-title":"Clin Cancer Res"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1175-y","article-title":"Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory","volume":"199","author":"Foley","year":"2008","journal-title":"Psychopharmacologia"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2310-8","article-title":"Effects of repeated administration of chemotherapeutic agents tamoxifen, methotrexate, and 5-fluorouracil on the acquisition and retention of a learned response in mice","volume":"217","author":"Walker","year":"2011","journal-title":"Psychopharmacologia"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.03.013","article-title":"Establishing a model for assessing DNA damage in murine brain cells as a molecular marker of chemotherapy-associated cognitive impairment","volume":"93","author":"Krynetskiy","year":"2013","journal-title":"Life Sci (1973)"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2010.08.019","article-title":"Single high dose treatment with methotrexate causes long-lasting cognitive dysfunction in laboratory rodents","volume":"97","author":"Fardell","year":"2010","journal-title":"Pharmacology Biochem behavior"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00029","article-title":"Impaired brain dopamine and serotonin release and uptake in wistar rats following treatment with carboplatin","volume":"7","author":"Kaplan","year":"2016","journal-title":"ACS Chem Neurosci"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.11.012","article-title":"Chemotherapy-induced long-term alteration of executive functions and hippocampal cell proliferation: Role of glucose as adjuvant","volume":"79","author":"Dubois","year":"2014","journal-title":"Neuropharmacology"},{"key":"B146","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbr.2016.11.042","article-title":"The chemotherapeutic agent paclitaxel selectively impairs learning while sparing source memory and spatial memory","volume":"320","author":"Smith","year":"2017","journal-title":"Behav Brain Res"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-015-0125-y","article-title":"Impairment of cognitive function by chemotherapy: association with the disruption of phase-locking and synchronization in anterior cingulate cortex","volume":"8","author":"Mu","year":"2015","journal-title":"Mol brain"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-1817","article-title":"Pifithrin-\u03bc Prevents cisplatin-induced chemobrain by preserving neuronal mitochondrial function","volume":"77","author":"Chiu","year":"2017","journal-title":"Cancer Res (Chicago Ill)"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00656-6","article-title":"Tamoxifen and toremifene cause impairment of learning and memory function in mice","volume":"71","author":"Chen","year":"2002","journal-title":"Pharmacology Biochem behavior"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00782-1","article-title":"Tamoxifen and toremifene impair retrieval, but not acquisition, of spatial information processing in mice","volume":"72","author":"Chen","year":"2002","journal-title":"Pharmacology Biochem behavior"},{"key":"B151","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00213-008-1448-5","article-title":"Tamoxifen disrupts consolidation and retrieval of morphine-associated contextual memory in male mice: interaction with estradiol","volume":"204","author":"Esmaeili","year":"2009","journal-title":"Psychopharmacologia"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2012.673515","article-title":"Evaluation of destructive effects of exposure to cisplatin during developmental stage: no profound evidence for sex differences in impaired motor and memory performance","volume":"122","author":"Shabani","year":"2012","journal-title":"Int J Neurosci"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1038\/nm749","article-title":"Irradiation induces neural precursor-cell dysfunction","volume":"8","author":"Palmer","year":"2002","journal-title":"Nat Med"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2012.05.005","article-title":"The effect of 5-fluorouracil on the long term survival and proliferation of cells in the rat hippocampus","volume":"88","author":"ELBeltagy","year":"2012","journal-title":"Brain Res Bull"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1186\/jbiol50","article-title":"CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo","volume":"5","author":"Dietrich","year":"2006","journal-title":"J Biol (London England)"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.06.093","article-title":"Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA","volume":"1111","author":"Mignone","year":"2006","journal-title":"Brain Res"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not321","article-title":"Consequences of cancer treatments on adult hippocampal neurogenesis: implications for cognitive function and depressive symptoms","volume":"16","author":"Pereira Dias","year":"2014","journal-title":"Neuro Oncol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.05.027","article-title":"Neuroinflammation after stereotactic radiosurgery-induced brain tumor disintegration is linked to persistent cognitive decline in a mouse model of metastatic disease","volume":"108","author":"Chu","year":"2020","journal-title":"Int J Radiat oncology biology physics"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.10.009","article-title":"Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release","volume":"207","author":"Seigers","year":"2010","journal-title":"Behav Brain Res"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1080\/713936678","article-title":"Carboplatin-induced oxidative injury in rat inferior colliculus","volume":"22","author":"Husain","year":"2003","journal-title":"Int J toxicology"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2009.03.011","article-title":"Cyclophosphamide-induced oxidative stress in brain: protective effect of hot short pepper (Capsicum frutescens L. var. abbreviatum)","volume":"62","author":"Oboh","year":"2010","journal-title":"Exp Toxicol Pathol"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00395.x","article-title":"Oxidative stress mediates neuronal DNA damage and apoptosis in response to cytosine arabinoside","volume":"78","author":"Geller","year":"2001","journal-title":"J Neurochem"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1080\/10715760500143478","article-title":"Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: Insight into chemobrain","volume":"39","author":"Joshi","year":"2005","journal-title":"Free Radical Res"},{"key":"B164","article-title":"Antioxidative effect of melatonin in rat brain oxidative stress induced by Adriamycin","volume":"53","author":"Montilla","year":"1997","journal-title":"Rev Esp Fisiol"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2006.05.005","article-title":"Oxidative stress induced by methotrexate alone and in the presence of methanol in discrete regions of the rodent brain, retina and optic nerve","volume":"165","author":"Rajamani","year":"2006","journal-title":"Toxicol letters"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-005-9003-8","article-title":"Effects of melatonin in reducing the toxic effects of doxorubicin","volume":"286","author":"Oz","year":"2006","journal-title":"Mol Cell Biochem"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-9196-5","article-title":"The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: protective effect of caffeic acid phenethyl ester","volume":"291","author":"Uzar","year":"2006","journal-title":"Mol Cell Biochem"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2015.05.001","article-title":"Curcumin alleviates cisplatin-induced learning and memory impairments","volume":"123","author":"Oz","year":"2015","journal-title":"Neurobiol Learn memory"},{"key":"B169","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11682-017-9674-2","article-title":"In vivo neuroimaging and behavioral correlates in a rat model of chemotherapy-induced cognitive dysfunction","volume":"12","author":"Barry","year":"2018","journal-title":"Brain Imaging behavior"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.01.007","article-title":"5-Fluorouracil impairs attention and dopamine release in rats","volume":"362","author":"Jarmolowicz","year":"2019","journal-title":"Behav Brain Res"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.07.003","article-title":"Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus","volume":"1672","author":"Thomas","year":"2017","journal-title":"Brain Res"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151890","article-title":"Metformin prevents cisplatin-induced cognitive impairment and brain damage in mice","volume":"11","author":"Zhou","year":"2016","journal-title":"PloS One"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"B174","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.ctrv.2004.05.003","article-title":"Endothelial cell effects of cytotoxics: balance between desired and unwanted effects","volume":"30","author":"de Vos","year":"2004","journal-title":"Cancer Treat Rev"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1387251\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T04:33:30Z","timestamp":1713846810000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1387251\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":174,"alternative-id":["10.3389\/fonc.2024.1387251"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2024.1387251","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]},"article-number":"1387251"}}