{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:20:43Z","timestamp":1775607643440,"version":"3.50.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to identify risk factors for right recurrent laryngeal nerve lymph node (RRLNLN) metastasis using computed tomography (CT) imaging histology and clinical data from patients with esophageal squamous cell carcinoma (ESCC), ultimately developing a clinical prediction model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from 370 patients who underwent surgical resection at the Department of Thoracic Surgery, Zhongshan Hospital of Xiamen University, from December 2014 to December 2020. Subsequently, the venous-stage chest-enhanced CT images of the patients were imported into 3DSlicer 4.11 software, allowing for the extraction of imaging histological features. Additionally, by combining the clinical data of the patients, single- and multifactor analyses were conducted to screen the risk factors and build a predictive model in the form of a nomogram. The area under the curve (AUC) was used as a discriminant for model accuracy, while differentiation and calibration methods were applied to further evaluate the model\u2019s accuracy. Finally, the Bootstrap resampling method was employed to repeat sampling 2,000 times to draw calibration curves, while the K-fold crossvalidation method was used for the internal validation of the prediction model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The RRLNLN lymph node metastasis rate was 17.3%. Four significant factors\u2014Maximum2DDiameterSlice, Mean, Imc1, and Dependence Entropy\u2014were identified. Alignment diagrams were subsequently constructed, yielding an AUC of 0.938 and a C-index of 0.904 during internal validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The model demonstrates high predictive accuracy, making it a valuable tool for guiding the development of preoperative protocols.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2024.1388355","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T06:47:43Z","timestamp":1739774863000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prediction of right recurrent laryngeal nerve lymph node metastasis in esophageal cancer based on computed tomography imaging 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