{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:54:38Z","timestamp":1776560078391,"version":"3.51.2"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Histiocytic sarcoma originates in various tissues, including the skin, lymph nodes, gastrointestinal tract, lungs, bone marrow, and central nervous system. Primary central nervous system histiocytic sarcoma (PCNSHS) is exceptionally rare, known for its aggressive behavior and poor prognosis. This report describes a case of PCNSHS in the cerebellum treated with surgery and radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 30-year-old woman presented with progressive dizziness and headache. Magnetic resonance imaging scans showed right cerebellar neoplastic lesions approximately 3.6 cm*3.0 cm with cerebral edema and fourth ventricle and brainstem compression. The patient underwent surgical debulking, and the pathological diagnosis was PCNSHS. Two months after the surgery, the patient underwent adjuvant radiotherapy at a dose of 60 Gy. No tumor progression has been observed during the one-year follow-up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case report provides an example of effective central nervous system control using resection and radiation therapy. A review of the literature confirms that surgery alone or combined concurrent or sequential treatment of radiotherapy and chemotherapy is often used; however, the best treatment plan remains unclear. Moreover, the prognosis is poor, with a median survival of six months. Thus, ongoing research aims to better understand the biology of histiocytic sarcomas and find more effective strategies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2024.1398350","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T06:31:08Z","timestamp":1734676268000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case report: Treatment of a rare primary cerebellum histiocytic sarcoma with surgery and radiotherapy"],"prefix":"10.3389","volume":"14","author":[{"given":"Li","family":"Yanchu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Qiongwen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duan","family":"Jiayu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3960\/jslrt.53.1","article-title":"Histiocytic sarcoma: an updated literature review based on the 2008 WHO classification","volume":"53","author":"Takahashi","year":"2013","journal-title":"J Clin Exp Hematopathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.24690","article-title":"Successful treatment of central nervous system histiocytic sarcoma with craniectomy and adjuvant radiotherapy","volume":"14","author":"Shahrokh","year":"2022","journal-title":"Cureus"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2010.07.002","article-title":"Primary intramedullary histiocytic sarcoma","volume":"74","author":"Toshkezi","year":"2010","journal-title":"World Neurosurg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-018-1115-x","article-title":"Primary histiocytic sarcoma of the central nervous system: a case report with platelet derived growth factor receptor mutation and PD-L1\/PD-L2 expression and literature review","volume":"13","author":"May","year":"2018","journal-title":"Radiat Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2013.163","article-title":"Primary histiocytic sarcoma of the central nervous system","volume":"47","author":"So","year":"2014","journal-title":"Cancer Res Treat"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-293050","article-title":"The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications","volume":"117","author":"Campo","year":"2011","journal-title":"Blood"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000131541.95394.23","article-title":"Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid Malignancy","volume":"28","author":"Hornick","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.11.002","article-title":"Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma: case report and literature review","volume":"44","author":"Wu","year":"2013","journal-title":"Hum Pathol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/neup.2018.38.issue-6","article-title":"Case of primary central nervous system histiocytic sarcoma with prominent proliferation of histiocytic cells between the trabeculae of reactive glial cells","volume":"38","author":"Takahashi","year":"2018","journal-title":"Neuropathology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/ejh.2016.97.issue-1","article-title":"Histiocytic sarcoma as a secondary Malignancy: pathobiology, diagnosis, and treatment","volume":"97","author":"Ansari","year":"2016","journal-title":"Eur J Haematol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000880","article-title":"Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib","volume":"83","author":"Idbaih","year":"2014","journal-title":"Neurology"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.02.009","article-title":"A case of primary central nervous system histiocytic sarcoma","volume":"114","author":"Wang","year":"2012","journal-title":"Clin Neurol Neurosurg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e11271","DOI":"10.1097\/MD.0000000000011271","article-title":"Primary central nervous system histiocytic sarcoma: A case report and review of literature","volume":"97","author":"Ma","year":"2018","journal-title":"Med (Baltimore)"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.5414\/NP301473","article-title":"Primary central nervous system histiocytic sarcoma with somatic NF2 mutation: Case report and review of literature","volume":"41","author":"Wang","year":"2022","journal-title":"Clin Neuropathol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s10014-023-00471-8","article-title":"A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review","volume":"4","author":"Zhang","year":"2024","journal-title":"Brain Tumor Pathol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2217\/fon.15.315","article-title":"Follicular dendritic cell sarcoma of mediastinum: a key role of radiotherapy in a multidisciplinary approach","volume":"11","author":"Spatola","year":"2015","journal-title":"Future Oncol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2016-0331","article-title":"Role, timing and technique of radiotherapy in pediatric pleuropulmonary synovial sarcoma","volume":"12","author":"Spatola","year":"2016","journal-title":"Future Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1398350\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T06:31:11Z","timestamp":1734676271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1398350\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":17,"alternative-id":["10.3389\/fonc.2024.1398350"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2024.1398350","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"article-number":"1398350"}}