{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:31Z","timestamp":1787026951879,"version":"build-2736575974"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    This case report aims to highlight the importance of considering lymphoma as a potential differential diagnosis in patients presenting with laryngeal mass and associated cervical lymphadenopathy, particularly those with a history of chronic tonsillitis. A case of a 63-year-old male patient who underwent bilateral tonsillectomy for tumor in the left tonsil was presented. Two months after the procedure, he developed throat discomfort, dysphagia, neck swelling, and other symptoms. The patient was initially diagnosed with \u201ctongue base mass\u201d and chronic lymphadenitis. Partial excision of the tongue base mass was performed twice in another hospital, revealing chronic inflammation of the epithelial mucosa. Further evaluations, including electron laryngoscopy and imaging studies, were conducted to investigate the condition. A computed tomography (CT) scan showed irregular soft tissue density in the oropharyngeal region, along with multiple lymph nodes in the neck. Subsequent histopathological examination of the lingual base biopsy revealed peripheral T-cell lymphoma with a follicular T-helper cell phenotype. Immunohistochemical staining confirmed specific markers while ruling out other markers.\n                    <jats:italic>In situ<\/jats:italic>\n                    hybridization testing demonstrated positivity for Epstein\u2013Barr virus-encoded RNA, and TCRG clonality was confirmed. The duration from symptom onset to diagnosis was 2 months. This case emphasizes the importance of considering lymphoma in patients with laryngeal mass and associated cervical lymphadenopathy, especially when a history of chronic tonsillitis is present. Accurate diagnosis and early intervention are crucial for effective management and improved patient outcomes.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2024.1424785","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:32:59Z","timestamp":1722213179000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: Suspicious laryngeal mass: a case of laryngeal lymphoma misdiagnosed as chronic inflammation"],"prefix":"10.3389","volume":"14","author":[{"given":"Juanjuan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoai","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1455613231170085","DOI":"10.1177\/01455613231170085","article-title":"Suspicious laryngeal mass: A case of recurrent mantle cell lymphoma","author":"Bernstein","year":"2023","journal-title":"Ear Nose Throat J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13256-017-1209-3","article-title":"Primary Burkitt lymphoma of the supraglottic larynx: a case report and review of the literature","volume":"11","author":"Quimby","year":"2017","journal-title":"J Med Case Rep"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27074","article-title":"Epidemiology and prognostic indicators in laryngeal lymphoma: A population-based analysis","volume":"128","author":"Hong","year":"2018","journal-title":"Laryngoscope"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2014.07.005","article-title":"Extranodal lymphoma of the head and neck: a 67-case series","volume":"132","author":"Picard","year":"2015","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"105858","DOI":"10.1016\/j.ijscr.2021.105858","article-title":"Primary laryngeal T-cell lymphoma: A case report and review of the literature","volume":"82","author":"Chaker","year":"2021","journal-title":"Int J Surg Case Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13005-018-0186-0","article-title":"Clinical presentation and characteristics of lymphoma in the head and neck region","volume":"15","author":"Storck","year":"2019","journal-title":"Head Face Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21022","article-title":"National Cancer Database report on cancer of the head and neck: 10-year update","volume":"31","author":"Cooper","year":"2009","journal-title":"Head Neck"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4103\/wjnm.WJNM_95_20","article-title":"Should fluorodeoxyglucose positron emission tomography\/computed tomography be the first-line imaging investigation for restaging the laryngeal carcinoma patients","volume":"20","author":"Jain","year":"2021","journal-title":"World J Nucl Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2085","article-title":"Imaging characteristics of primary laryngeal lymphoma","volume":"31","author":"Siddiqui","year":"2010","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1424785\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:33:02Z","timestamp":1722213182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1424785\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":9,"alternative-id":["10.3389\/fonc.2024.1424785"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2024.1424785","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"article-number":"1424785"}}