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Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Almost all cases of malignant acanthosis nigricans with oral manifestations occurred in older age groups. Here, we report a case of malignant acanthosis nigricans in a young female presented with chief complaints of oral mucosal hyperplasia, who had previously been diagnosed with allergies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 30-year-old female developed oral hyperplasia and rash following seafood consumption, with subsequent resolution of the rash but persistent oral lesions and the appearance of pigmentation on her hands, neck, and axillae. Clinical examination revealed papillomatosis, hyperemia, and velvety hyperplasia in the oral cavity. Biopsy results confirmed papillary hyperplasia. Despite the patient\u2019s belief in good health, she was advised to undergo further systemic examinations. Elevated serum tumor markers and histologic analysis of an endoscopic biopsy confirmed gastric cancer with duodenal infiltration, leading to the diagnosis of malignant acanthosis nigricans. Unfortunately, the patient passed away due to heart failure during chemotherapy treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of patients with malignant acanthosis nigricans present with oral lesions before the underlying malignancy is detected, emphasizing the importance of timely comprehensive systemic examination. Furthermore, our case suggests that age may not be a restrictive factor for the development of malignant acanthosis nigricans, and the presence of a rash can potentially obscure the cutaneous manifestations associated with this condition.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2024.1459148","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T06:53:44Z","timestamp":1727160824000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Malignant acanthosis nigricans with oral manifestations in a young female: a case report and literature review"],"prefix":"10.3389","volume":"14","author":[{"given":"Zijian","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuling","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13544","article-title":"Acanthosis nigricans: A review","volume":"19","author":"Das","year":"2020","journal-title":"J Cosmet Dermatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2015.04.010","article-title":"Acanthosis nigricans: A fold (intertriginous) dermatosis","volume":"33","author":"Kutlubay","year":"2015","journal-title":"Clin Dermatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.016","article-title":"Juvenile acanthosis nigricans","volume":"57","author":"Sinha","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.867","article-title":"Insulin resistance, acanthosis nigricans, and hypertriglyceridemia","volume":"52","author":"Eberting","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2014.1","article-title":"Oral Malignant acanthosis nigricans associated with endometrial adenocarcinoma","volume":"6","author":"Chu","year":"2014","journal-title":"Int J Oral Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12957-017-1274-5","article-title":"Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma","volume":"15","author":"Yu","year":"2017","journal-title":"World J Surg Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S290124","article-title":"Malignant acanthosis nigricans with recurrent bladder cancer: A case report and review of literature","volume":"14","author":"Zhang","year":"2021","journal-title":"Onco Targets Ther"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.21405","article-title":"Inflammatory papillary hyperplasia: A systematic review","volume":"22","author":"Gual-Vaqu\u00e9s","year":"2017","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12009","article-title":"Focal epithelial hyperplasia - an update","volume":"42","author":"Said","year":"2013","journal-title":"J Oral Pathol Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04493.x","article-title":"2012 European guideline for the management of anogenital warts","volume":"27","author":"Lacey","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0777-7","article-title":"Multiple oral mucosal hamartomas in a 34-year old female","volume":"11","author":"Elo","year":"2017","journal-title":"Head Neck Pathol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00052.x","article-title":"A case of EEC syndrome with peri\/intraoral papillomatosis and widespread freckling","volume":"33","author":"Mansur","year":"2006","journal-title":"J Dermatol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01355.x","article-title":"Review of linear epidermal nevus with oral mucosal involvement\u2013series of five new cases","volume":"14","author":"Haberland-Carrodeguas","year":"2008","journal-title":"Oral Dis"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.046","article-title":"Linear intraoral lesions in the sebaceous nevus syndrome","volume":"52","author":"Warnke","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31478","article-title":"Oral phenotype and variation in focal dermal hypoplasia","author":"Wright","year":"2016","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.642","article-title":"Acanthosis nigricans as a paraneoplastic syndrome. 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