{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:54:46Z","timestamp":1781902486665,"version":"3.54.5"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Gastric cancer ranks fourth among the most commonly diagnosed cancers, with over a million new cases diagnosed worldwide each year. Acute and chronic kidney damage are common in patients with malignant diseases and are associated with increased risk of complications and mortality. Rarely, acute renal insufficiency may result from bilateral infiltration of renal parenchyma by tumor cells from another organ. We present a case of a patient with clinical suspected gastric cancer and metastases to the kidneys leading to acute renal failure requiring hemodialysis. Despite gastric biopsies, no tumor cells were found, while histopathological examination of enlarged intra-abdominal lymph node biopsy material confirmed adenocarcinoma of signet ring cell originating from the digestive system. Stomach cancer was identified as the most likely primary site after the kidney biopsy was performed. To the best of our knowledge, no case of gastric cancer leading to kidney metastases and acute renal failure requiring renal replacement therapy was yet described. Multidisciplinary collaboration among oncologists, urologists, radiologists, pathologists, and nephrologists is essential for the optimal treatment outcome of these patients, who generally have a poor prognosis.<\/jats:p>","DOI":"10.3389\/fonc.2024.1459470","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T04:42:06Z","timestamp":1724906526000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Renal metastasis of gastric cancer caused acute kidney injury which resulted with hemodialysis: case report and literature review"],"prefix":"10.3389","volume":"14","author":[{"given":"Ivo","family":"Dilber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stjepko","family":"Ple\u0161tina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domina","family":"Kekez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana Vukovac","family":"\u0160okec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"\u0106ori\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Prejac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.07.004","article-title":"Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"33","author":"Lordick","year":"2022","journal-title":"Ann Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.608","article-title":"Effect of endoscopy screening on stage at gastric cancer diagnosis: results of the National Cancer Screening Programme in Korea","volume":"112","author":"Choi","year":"2015","journal-title":"Br J Cancer"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2021.02.05","article-title":"Screening for gastric cancer in China: Advances, challenges and visions","volume":"33","author":"Fan","year":"2021","journal-title":"Chin J Cancer Res"},{"key":"B4","unstructured":"NCCN guidelines version 2.2023 gastric cancer"},{"key":"B5","first-page":"85","article-title":"Acute kidney injury: definition, pathophysiology and clinical phenotypes","volume":"37","author":"Makris","year":"2016","journal-title":"Clin Biochem Rev"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11040611","article-title":"Acute kidney injury in the patient with cancer","volume":"11","author":"Meraz-Munoz","year":"2021","journal-title":"Diagnost (Basel)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32563-2","article-title":"Acute kidney injury","volume":"394","author":"Ronco","year":"2019","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i35.10746","article-title":"Management of acute kidney injury in gastrointestinal tumor: An overview","volume":"9","author":"Su","year":"2021","journal-title":"World J Clin Cases"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/08860220600580423","article-title":"Acute renal failure secondary to small cell lung cancer with tumor infiltration of the kidneys","volume":"28","author":"Wen","year":"2006","journal-title":"Ren Fail"},{"key":"B10","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/cc4907","article-title":"Clinical review: specific aspects of acute renal failure in cancer patients","volume":"10","author":"Darmon","year":"2006","journal-title":"Crit Care"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.12865\/CHSJ.46.01.11","article-title":"Metastases to the kidney: A case report and review of the literature","volume":"46","author":"Cazacu","year":"2020","journal-title":"Curr Health Sci J"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0341-x","article-title":"Molecular alterations of cancer cell and tumour microenvironment in metastatic gastric cancer","volume":"37","author":"Li","year":"2018","journal-title":"Oncogene"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1159\/000225269","article-title":"The metastatic spread of cancers of the digestive system in man","volume":"35","author":"Viadana","year":"1978","journal-title":"Oncology"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13194","article-title":"Metastases to the kidney: a comprehensive analysis of 151 patients from a tertiary referral centre","volume":"117","author":"Zhou","year":"2016","journal-title":"BJU Int"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.632221","article-title":"Metastases to the kidney: an analysis of 35 cases and a review of literature","volume":"10","author":"Chen","year":"2021","journal-title":"Front Oncol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-003-0259-y","article-title":"Gastric cancer diagnosed in a patient with crescentic glomerulonephritis","volume":"6","author":"Yavuzsen","year":"2003","journal-title":"Gastric Cancer"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2002","article-title":"Case report: Gastric cancer-associated membranous nephropathy that recurred after complete remission and formation of peritoneal dissemination","volume":"7","author":"Kajiwara","year":"2019","journal-title":"Clin Case Rep"},{"key":"B18","article-title":"Glom\u00e9rulon\u00e9phrite \u00e0 croissants associ\u00e9e \u00e0 un ad\u00e9nocarcinome gastrique [Crescentic Glomerulonephritis associated with gastric adenocarcinoma]","volume":"13","author":"Dussol","year":"1992","journal-title":"Nephrologie"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-020-00541-2","article-title":"Extensive bilateral renal metastases of non-small cell lung carcinoma caused acute kidney injury resulting in end-stage renal disease","volume":"10","author":"Miyamoto","year":"2021","journal-title":"CEN Case Rep"},{"key":"B20","article-title":"[A case of right kidney metastasis of gastric cancer]","volume":"48","author":"Akimoto","year":"2021","journal-title":"Gan To Kagaku Ryoho"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1459470\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T04:42:12Z","timestamp":1724906532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1459470\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":20,"alternative-id":["10.3389\/fonc.2024.1459470"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2024.1459470","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"article-number":"1459470"}}