{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:13:37Z","timestamp":1753892017093,"version":"3.41.2"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hemangiopericytoma (HPC) is a rare secondary tumor after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which has not been reported in the literature. Herein, we reported a case of HPC after allo-HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case description<\/jats:title><jats:p>We reported a case of a middle-aged female patient with primary plasma cell leukemia who presented lumbosacral pain and right lower limb pain and numbness on1684 days post-transplant. She underwent an MRI of the lumbar spine, which showed abnormal signal intensity in the spinal canal at the second through fifth lumbar spine vertebral levels. The patient was diagnosed with HPC based on a pathological biopsy of the diseased tissue in the spinal canal. Radiotherapy was administered to the lesion in the second through fifth lumbar vertebrae. The patient experienced less numbness and pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to the literature, this is the first reported case of post-transplant HPC. Therefore, attention should be paid to secondary tumors after transplantation, especially rare tumors.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2024.1467237","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T06:21:55Z","timestamp":1731565315000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemangiopericytoma following allogeneic hematopoietic stem cell transplantation in a patient with primary plasma cell leukemia: the first case report and literature review"],"prefix":"10.3389","volume":"14","author":[{"given":"Yajun","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglian","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunyu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.203","article-title":"Second cancers and late mortality in Australian children treated by allogeneic HSCT for haematological Malignancy","volume":"29","author":"Nelson","year":"2015","journal-title":"Leukemia"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34115","article-title":"Risk of secondary nonhematologic Malignancies after allogeneic stem cell transplantation: A nationwide case-control cohort study","volume":"151","author":"Park","year":"2022","journal-title":"Int J Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/bmt.2011.23","article-title":"Secondary solid tumors after allogeneic hematopoietic SCT in Japan","volume":"47","author":"Yokota","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-22-700","article-title":"Outcomes of patients with esophageal cancer after allogeneic hematopoietic stem cell transplantation","volume":"13","author":"Vasudevan","year":"2022","journal-title":"J Gastrointest Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2020_200214N131","article-title":"Total body irradiation is a crucial risk factor for developing secondary carcinomas after allogeneic hematopoietic stem cell transplantation in childhood","volume":"67","author":"Keslova","year":"2020","journal-title":"Neoplasma"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.07.009","article-title":"Second solid cancers after allogeneic hematopoietic cell transplantation using reduced-intensity conditioning","volume":"20","author":"Ringden","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"B7","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s00432-024-05679-5","article-title":"Secondary solid Malignancies and precancerous lesions after allogeneic hematopoietic stem cell transplantation using non-total body irradiation-based conditioning in acute myeloid leukemia","volume":"150","author":"Isabella","year":"2024","journal-title":"J Cancer Res Clin Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e654","DOI":"10.1097\/HS9.0000000000000654","article-title":"Second solid cancers after hematopoietic stem cell transplantation: active surveillance during long-term follow-up","volume":"5","author":"Lupo-Stanghellini","year":"2021","journal-title":"Hemasphere"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01715-5","article-title":"Life expectancy and burden of late complications after reduced intensity conditioning allogeneic transplantation","volume":"57","author":"Del","year":"2022","journal-title":"Bone Marrow Transplant"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.02.015","article-title":"Long-term incidence of secondary Malignancies after allogeneic hematopoietic cell transplantation: A single-center experience","volume":"23","author":"Michelis","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-02926-6","article-title":"Programmed death 1 ligand (PD-L1) in solid cancers after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Nagasaki Transplant Group","volume":"112","author":"Kasai","year":"2020","journal-title":"Int J Hematol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4934","article-title":"Evaluation of second solid cancers after hematopoietic stem cell transplantation in european patients","volume":"5","author":"Tichelli","year":"2019","journal-title":"JAMA Oncol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-020-03500-7","article-title":"Secondary esophageal squamous cell carcinoma after hematopoietic stem cell transplantation","volume":"147","author":"Nomura","year":"2021","journal-title":"J Cancer Res Clin Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0073","article-title":"Malignant and benign thyroid nodules after total body irradiation preceding hematopoietic cell transplantation during childhood","volume":"167","author":"Vivanco","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24328","article-title":"Hemangiopericytoma arising from the cartilage of the external auditory canal","volume":"38","author":"Castiglione","year":"2016","journal-title":"Head Neck"},{"key":"B16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2468320","article-title":"Hemangiopericytoma: incidence, treatment, and prognosis analysis based on SEER database","volume":"2020","author":"Wang","year":"2020","journal-title":"BioMed Res Int"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000146","article-title":"CNS hemangiopericytoma: A systematic review of 523 patients","volume":"40","author":"Ghose","year":"2017","journal-title":"Am J Clin Oncol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-015-3789-1","article-title":"Spinal hemangiopericytoma: an institutional experience and review of literature","author":"Das","year":"2015","journal-title":"Eur Spine J"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-007-0372-z","article-title":"Hemangiopericytoma of thoracic spine: a rare bony tumor","volume":"23","author":"Kumar","year":"2007","journal-title":"Childs Nerv Syst"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0466-y","article-title":"Extra- and intracranial dumbbell-shaped hemangiopericytoma","volume":"265","author":"Diensthuber","year":"2008","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-022-01718-5","article-title":"Hemangiopericytoma\/solitary fibrous tumor of the cranial base: a case series and literature review","volume":"22","author":"Peng","year":"2022","journal-title":"BMC Surg"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2011.01.019","article-title":"Unrecognized hemangiopericytoma of posterior cervical region with intracranial extension","volume":"40","author":"Vilendecic","year":"2012","journal-title":"J Craniomaxillofac Surg"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1673.2001.00935.x","article-title":"Haemangiopericytoma of the trigeminal nerve","volume":"45","author":"Tan","year":"2001","journal-title":"Australas Radiol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599073","article-title":"Intracranial hemangiopericytomas: recurrence, metastasis, and radiotherapy","volume":"78","author":"Patel","year":"2017","journal-title":"J Neurol Surg B Skull Base"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21448","article-title":"Precision radiotherapy for hemangiopericytomas of the central nervous system","volume":"104","author":"Combs","year":"2005","journal-title":"Cancer-Am Cancer Soc"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-023-04499-w","article-title":"Postoperative stereotactic radiosurgery for intracranial solitary fibrous tumors: systematic review and pooled quantitative analysis","volume":"165","author":"Golub","year":"2023","journal-title":"J Neurooncol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200203000-00045","article-title":"Intradural hemangiopericytoma of the lumbar spine: case report","volume":"50","author":"Betchen","year":"2002","journal-title":"Neurosurgery"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303499","article-title":"Hemangiopericytoma: a 20-year single-institution experience","volume":"5","author":"Spitz","year":"1998","journal-title":"Ann Surg Oncol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-021-01812-0","article-title":"Skull base hemangiopericytomas","volume":"122","author":"Tobias","year":"2022","journal-title":"Acta Neurol Belg"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1177\/2192568221994799","article-title":"Imaging characteristics and surgical outcomes in patients with intraspinal solitary fibrous tumor\/hemangiopericytoma: A retrospective cohort study","volume":"13","author":"Okubo","year":"2023","journal-title":"Global Spine J"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-024-10204-8","article-title":"Advances in the molecular biology of the solitary fibrous tumor and potential impact on clinical applications","author":"Ren","year":"2024","journal-title":"Cancer Metastasis Rev"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12987","article-title":"Subsequent Malignancies after allogeneic hematopoietic stem cell transplantation","volume":"31","author":"Gunduz","year":"2017","journal-title":"Clin Transplant"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.9.3633.bloodjournal8793633","article-title":"Malignant neoplasms following bone marrow transplantation","volume":"87","author":"Bhatia","year":"1996","journal-title":"Blood"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.63","article-title":"Secondary solid cancer screening following hematopoietic cell transplantation","volume":"50","author":"Inamoto","year":"2015","journal-title":"Bone Marrow Transplant"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-294629","article-title":"Secondary solid cancers after allogeneic hematopoietic cell transplantation using busulfan-cyclophosphamide conditioning","volume":"117","author":"Majhail","year":"2011","journal-title":"Blood"},{"key":"B37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11864-018-0528-y","article-title":"Second Malignancies after hematopoietic stem cell transplantation","volume":"19","author":"Danylesko","year":"2018","journal-title":"Curr Treat Options Oncol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3411","article-title":"Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study","volume":"105","author":"Curtis","year":"2005","journal-title":"Blood"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.4","article-title":"Increased incidence of oral and gastrointestinal secondary cancer after allogeneic hematopoietic stem cell transplantation","volume":"52","author":"Tanaka","year":"2017","journal-title":"Bone Marrow Transplant"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001355","article-title":"Genetic profile and microsatellite instability in a case of secondary esophageal squamous cell carcinoma 12 years after allogeneic hematopoietic stem cell transplantation for aplastic anemia","volume":"42","author":"Akiyama","year":"2020","journal-title":"J Pediatr Hematol Oncol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.12.519","article-title":"Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation","volume":"18","author":"Majhail","year":"2012","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1467237\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T06:21:57Z","timestamp":1731565317000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1467237\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":41,"alternative-id":["10.3389\/fonc.2024.1467237"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2024.1467237","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2024,11,14]]},"article-number":"1467237"}}