{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:49Z","timestamp":1753891849090,"version":"3.41.2"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"Background<\/jats:title>Extramedullary hemopoiesis (EMH) is a rare condition characterized by abnormal blood cell production outside the bone marrow, commonly occurring in the liver, spleen, lymph nodes, and less frequently in the mediastinum.<\/jats:p><\/jats:sec>Case presentation<\/jats:title>This case involves a 68-year-old male patient who was found to have a posterior mediastinal mass upon examination. A surgical biopsy was performed, and pathological examination confirmed it to be extramedullary hemopoiesis (EMH). Further investigation revealed that the patient also suffered from hemolytic anemia.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The report presents a case of a large posterior mediastinal mass, which was confirmed to be extramedullary hemopoiesis (EMH) upon surgical pathology. It is challenging to differentiate posterior mediastinal tumors from EMH, and the possibility of EMH should be considered in patients with posterior mediastinal masses that have similar CT findings and laboratory test results.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2024.1489785","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T05:10:43Z","timestamp":1734066643000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Huge extramedullary hematopoiesis mass in the posterior mediastinum: a case report"],"prefix":"10.3389","volume":"14","author":[{"given":"Zhao","family":"Junjun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Lingjun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma","family":"Zhifeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Haiyong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.179.5.1791239","article-title":"Typical and atypical presentations of extramedullary hemopoiesis","volume":"179","author":"Georgiades","year":"2002","journal-title":"Am J Roentgenol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(98)00101-6","article-title":"Extramedullary paraspinal hematopoiesis in thalassemia: CT and MRI evaluation","volume":"30","author":"Tsitouridis","year":"1999","journal-title":"Eur J Radiol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1177\/0300985811432344","article-title":"Extramedullary hematopoiesis: A new look at the underlying stem cell niche, theories of development, and occurrence in animals","volume":"49","author":"Johns","year":"2012","journal-title":"Vet Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.05.042","article-title":"Intrathoracic extramedullary hematopoiesis manifested as a neoplastic lesion within anterior mediastinum","volume":"88","author":"Santini","year":"2009","journal-title":"Ann Thorac Surgery"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3855","article-title":"Extramedullary hematopoiesis: A report of two cases","volume":"12","author":"Zhang","year":"2016","journal-title":"Exp Ther Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.358","article-title":"Surgical resection of extramedullary hematopoiesis in the posterior mediastinum","volume":"6","author":"Matsumoto","year":"2018","journal-title":"Respirol Case Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2007.00965.x","article-title":"Effect of hydroxyurea on extramedullary hematopoiesis in thalassemia intermedia: case reports and literature review","volume":"30","author":"Meo","year":"2008","journal-title":"Int J Lab Hematol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"5246","DOI":"10.1182\/blood-2023-178053","article-title":"Case series of paraspinal extramedullary hematopoiesis in transfusion-dependent thalassemia treated with luspatercept","volume":"142","author":"Mreiwed","year":"2023","journal-title":"Blood"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/14782715221088912","article-title":"Spinal cord compression secondary to extramedullary hematopoiesis in transformed polycythemia rubra vera","volume":"52","author":"Randhawa","year":"2022","journal-title":"J\u00a0R Coll Phys Edinburgh"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1489785\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T05:10:45Z","timestamp":1734066645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2024.1489785\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,13]]},"references-count":9,"alternative-id":["10.3389\/fonc.2024.1489785"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2024.1489785","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2024,12,13]]},"article-number":"1489785"}}