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We searched this field on the basis of PubMed, Google Scholar, Web of Science, and Scopus databases. Most studies show that <jats:italic>H. pylori<\/jats:italic> inhibits the colonization of other bacteria, resulting in a less variety of bacteria in the gastrointestinal (GI) tract. When comparing the patients with <jats:italic>H. pylori\u2013<\/jats:italic>positive and <jats:italic>H. pylori<\/jats:italic>\u2013negative GC, the composition of the gastric microbiome changes with increasing abundance of <jats:italic>H. pylori<\/jats:italic> (where present) in the gastritis stage, whereas, as the gastric carcinogenesis cascade progresses to GC, oral and intestinal-type pathogenic microbial strains predominate. <jats:italic>H. pylori<\/jats:italic> infection induces a premalignant milieu of atrophy and intestinal metaplasia, and the resulting change in gastric microbiota appears to play an important role in gastric carcinogenesis. The effect of <jats:italic>H. pylori<\/jats:italic>\u2013induced GC on GI microbiota is discussed in this review.<\/jats:p>","DOI":"10.3389\/fonc.2024.1495596","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T06:11:38Z","timestamp":1736489498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Helicobacter pylori\u2013induced gastric cancer on gastrointestinal microbiota: a narrative review"],"prefix":"10.3389","volume":"14","author":[{"given":"Mohsen","family":"Heidary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sousan","family":"Akrami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohid","family":"Madanipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafiseh 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