{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:36:14Z","timestamp":1791048974692,"version":"4.1.0"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011828","name":"Guangxi Zhuang Autonomous Region Health and Family Planning Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Perivascular epithelioid cell tumours (PEComas) occurring in the uterus are rare, with surgery being the most recommended primary treatment for malignant cases. This study aims to provide clinical guidance on the clinicopathological features and appropriate treatment options for patients with uterine PEComas of uncertain malignant potential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Cases<\/jats:title><jats:p>This case series summarises the clinical courses of 13 patients diagnosed with uterine PEComas of uncertain malignant potential, including clinical and pathological data as well as their outcomes. We identified one case at our hospital, and data for the other 12 cases were extracted from the PubMed database. The 13 patients were aged 9\u201375 years, with tumour sizes ranging from 1 to 21\u00a0cm, and follow-up times ranging from 2 to 71 months. The most common signs and symptoms included abnormal uterine bleeding (AUB) and abdominal pain. Most of the patients (11\/13) were managed surgically without any chemotherapy or radiation therapy. Except for the patients who were lost to follow-up, 11 patients were free of any recurrence or metastasis at their last follow-up. Patients with group A tumours (abundant HMB45 expression) had a longer disease-free survival than those with group B tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Surgery alone may be appropriate for uterine PEComas of uncertain malignant potential. Surgical treatment plans should consider the patient\u2019s age, fertility requirements, and personal preferences. Mass resection is a viable treatment option for fertility preservation in reproductive-age patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2024.1521253","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T06:40:49Z","timestamp":1737960049000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Mass resection as a candidate treatment for uterine PEComas of uncertain malignant potential: a case report and literature review"],"prefix":"10.3389","volume":"14","author":[{"given":"Haijuan","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoujun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingfeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijsu.2015.05.002","article-title":"Perivascular epithelioid cell neoplasm (PEComa) of the uterus: A systematic review","volume":"19","author":"Musella","year":"2015","journal-title":"Int J Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28657","article-title":"Sarcoma classification: an update based on the 2013 World Health Organization Classification of tumours of Soft Tissue and Bone","volume":"120","author":"Doyle","year":"2014","journal-title":"Cancer"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2020.100603","article-title":"Perivascular epithelioid cell tumours (PEComa) of the female genital tract: A challenging question for gynaecologic oncologist and pathologist","volume":"33","author":"Gadducci","year":"2020","journal-title":"Gynecol Oncol Rep"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880351","article-title":"Abdominopelvic sarcoma of perivascular epithelioid cells. 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