{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:24:01Z","timestamp":1768973041341,"version":"3.49.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Desmoplastic infantile ganglioglioma (DIG) is a rare intracranial benign tumor occurring in infants under 2 years of age. It has good biological and behavioral characteristics and occasionally has malignant characteristics, such as multiple intracranial lesions, postoperative progression or recurrence, meningeal diffusion, and metastasis. We present a non-infant with DIG who underwent tumor progression. A 16-year-old girl presented with DIG in the cerebral cistern and underwent subtotal resection. A magnetic resonance imaging (MRI) of the brain 2 years later revealed that the area of abnormal enhancement in the surgical site was approximately the same as before, and follow-up was continued. A reexamination 5 years later showed that the residual extent of the operative area was significantly larger than before and involved the right frontal and temporal lobes, considering the progression of the residual part of the tumor. This case report focuses on the occurrence of DIG and its potential malignant features, as assessed through magnetic resonance imaging.<\/jats:p>","DOI":"10.3389\/fonc.2025.1411213","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T06:50:20Z","timestamp":1739170220000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Progression and diagnostic challenges of desmoplastic infantile ganglioglioma in a non-infant: a case report with 5-year follow-up"],"prefix":"10.3389","volume":"15","author":[{"given":"Yan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuzhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-0075-2","article-title":"Desmoplastic infantile astrocytoma with benign histological phenotype and multiple intracranial localizations at presentation","volume":"98","author":"Uro-Coste","year":"2010","journal-title":"J Neurooncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.08.091","article-title":"Infantile and noninfantile desmoplastic astrocytoma and ganglioglioma: only different age of onset","volume":"144","author":"Li","year":"2020","journal-title":"World Neurosurg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3171\/jns.1987.66.1.0058","article-title":"Desmoplastic supratentorial neuroepithelial tumors of infancy with divergent differentiation potential (\u201cdesmoplastic infantile gangliogliomas\u201d). Report on 11 cases of a distinctive embryonal tumor with favorable prognosis","volume":"66","author":"VandenBerg","year":"1987","journal-title":"J Neurosurg"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6226","article-title":"Mixed solid and cystic mass in an infant","volume":"40","author":"Benson","year":"2019","journal-title":"AJNR Am J Neuroradiol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-016-3126-y","article-title":"Desmoplastic astrocytoma: new insights into its clinical profile, diagnosis, and treatment","volume":"32","author":"Rojas-Medina","year":"2016","journal-title":"Childs Nerv Syst"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2019.32.113.12669","article-title":"Desmoplastic infantile ganglioglioma","volume":"32","author":"Kamoun","year":"2019","journal-title":"Pan Afr Med J"},{"key":"B8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.5414\/np300945","article-title":"Desmoplastic infantile astrocytoma and ganglioglioma: case report and review of the literature","volume":"36","author":"Samkari","year":"2017","journal-title":"Clin Neuropathol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.608129","article-title":"Multifocal desmoplastic infantile ganglioglioma\/astrocytoma (DIA\/DIG): an institutional series report and a clinical summary of this rare tumor","volume":"11","author":"Wang","year":"2021","journal-title":"Front Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.Mcr-17-0507","article-title":"Desmoplastic infantile ganglioglioma\/astrocytoma (DIG\/DIA) are distinct entities with frequent BRAFV600 mutations","volume":"16","author":"Wang","year":"2018","journal-title":"Mol Cancer Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1272831","article-title":"Malignant transformation of desmoplastic infantile tumors in a non-infant: a case report","volume":"13","author":"Yang","year":"2023","journal-title":"Front Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-016-3274-0","article-title":"Atypical imaging in a desmoplastic non-infantile astrocytoma","volume":"33","author":"Gupta","year":"2017","journal-title":"Childs Nerv Syst"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-022-01531-3","article-title":"Pleomorphic Xanthoastrocytoma: a single institution retrospective analysis and a review of the literature","volume":"127","author":"Detti","year":"2022","journal-title":"Radiol Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-018-0981-1","article-title":"Magnetic resonance imaging findings of mixed neuronal-glial tumors with pathologic correlation: a review","volume":"118","author":"Demir","year":"2018","journal-title":"Acta Neurol Belg"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/0883073820937225","article-title":"Pilocytic astrocytoma: A review of general, clinical, and molecular characteristics","volume":"35","author":"Salles","year":"2020","journal-title":"J Child Neurol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s13244-014-0328-2","article-title":"Manifestations of pilocytic astrocytoma: a pictorial review","volume":"5","author":"Chourmouzi","year":"2014","journal-title":"Insights Imaging"},{"key":"B17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00381-016-3262-4","article-title":"MR imaging of brain pilocytic astrocytoma: beyond the stereotype of benign astrocytoma","volume":"33","author":"Gaudino","year":"2017","journal-title":"Childs Nerv Syst"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-018-4224-7","article-title":"Differential diagnosis of posterior fossa tumours in children: new insights","volume":"48","author":"D\u2019Arco","year":"2018","journal-title":"Pediatr Radiol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-009-0878-7","article-title":"Imaging of ependymomas: MRI and CT","volume":"25","author":"Yuh","year":"2009","journal-title":"Childs Nerv Syst"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-021-03860-1","article-title":"Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma-and individual participant data meta-analysis (IPDMA)","volume":"155","author":"Wang","year":"2021","journal-title":"J Neurooncol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2011.04.001","article-title":"Malignant transformation of a desmoplastic infantile ganglioglioma","volume":"45","author":"Loh","year":"2011","journal-title":"Pediatr Neurol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1411213\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T06:50:21Z","timestamp":1739170221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1411213\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":21,"alternative-id":["10.3389\/fonc.2025.1411213"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1411213","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]},"article-number":"1411213"}}