{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:13:15Z","timestamp":1783606395601,"version":"3.55.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Spontaneous bacterial peritonitis (SBP) is an infectious condition characterizing the presence of bacterial infection in the peritoneal fluid with no apparent source of infection within the abdomen. It is extremely rare for patients with malnutrition after colorectal cancer (CRC) surgery to develop SBP. This is the first ever case reported case of SBP resulting from intestinal barrier compromise in a patient with colorectal cancer with malnutrition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>A 72-year-old woman with malnutrition was diagnosed with CRC, and following brief nutritional support, she underwent the laparoscopic-assisted radical right hemicolectomy. The patient was then diagnosed with peritonitis after the operation. An emergency laparotomy was performed, and the patient was finally diagnosed with SBP. The patient ultimately recovered following a series of appropriate postoperative supportive treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case highlights the poor outcomes of short preoperative nutritional therapy in CRC patients with malnutrition. Further studies should investigate the role of the intestinal barrier function in the recovery of patients with CRC after surgery.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1444149","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T06:47:40Z","timestamp":1739774860000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: A case report and literature review on spontaneous bacterial peritonitis induced by intestinal barrier damage in a colorectal cancer patient with malnutrition"],"prefix":"10.3389","volume":"15","author":[{"given":"Peng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanbao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"104809","DOI":"10.1016\/j.ebiom.2023.104809","article-title":"Rebalancing of mitochondrial homeostasis through an NAD(+)-SIRT1 pathway preserves intestinal barrier function in severe malnutrition","volume":"96","author":"Ling","year":"2023","journal-title":"EBioMedicine"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.846155","article-title":"Pathologic inflammation in malnutrition is driven by proinflammatory intestinal microbiota, large intestine barrier dysfunction, and translocation of bacterial lipopolysaccharide","volume":"13","author":"Patterson","year":"2022","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1001\/jama.2020.10292","article-title":"Spontaneous bacterial peritonitis","volume":"325","author":"Zhang","year":"2021","journal-title":"JAMA"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/life13040991","article-title":"Gut microbiota and infectious complications in advanced chronic liver disease: focus on spontaneous bacterial peritonitis","volume":"13","author":"Maccauro","year":"2023","journal-title":"Life (Basel)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040910","article-title":"Malnutrition in hospitalized old patients: screening and diagnosis, clinical outcomes, and management","volume":"14","author":"Bellanti","year":"2022","journal-title":"Nutrients"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/apt.2015.41.issue-11","article-title":"Review article: spontaneous bacterial peritonitis\u2013bacteriology, diagnosis, treatment, risk factors and prevention","volume":"41","author":"Dever","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"B7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistic","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"B8","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s12957-023-03138-y","article-title":"Perioperative outcomes of robotic and laparoscopic surgery for colorectal cancer: a propensity score-matched analysis","volume":"21","author":"Farah","year":"2023","journal-title":"World J Surg Oncol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12885-018-5232-6","article-title":"Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first international randomized controlled trial for multimodal prehabilitation","volume":"19","author":"Van Rooijen","year":"2019","journal-title":"BMC Cancer"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1076589","article-title":"Prognostic significance of sarcopenia diagnosed based on the anthropometric equation for progression-free survival and overall survival in patients with colorectal cancer","volume":"10","author":"Xie","year":"2023","journal-title":"Front Nutr"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2019.1708997","article-title":"Long-term outcome in gastric cancer patients with different body composition score assessed via computed tomography","volume":"34","author":"Zhou","year":"2021","journal-title":"J Invest Surg"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2010.01070.x","article-title":"Nutritional status of preoperative colorectal cancer patients","volume":"23","author":"Burden","year":"2010","journal-title":"J Hum Nutr Diet"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10844","article-title":"Ability of malnutrition screening and assessment tools to identify computed tomography defined low muscle mass in colorectal cancer surgery","volume":"37","author":"Djordjevic","year":"2022","journal-title":"Nutr Clin Pract"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.850063","article-title":"Poor pre-operative nutritional status is a risk factor of post-operative infections in patients with gastrointestinal cancer-A multicenter prospective cohort study","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Nutr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/00004836-200304000-00004","article-title":"Enteral nutritional support of the patient with cancer: route and role","volume":"36","author":"Schattner","year":"2003","journal-title":"J Clin Gastroenterol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/nu14010207","article-title":"Malnutrition and increased risk of adverse outcomes in elderly patients undergoing elective colorectal cancer surgery: A case-control study nested in a cohort","volume":"14","author":"Martinez-Escribano","year":"2022","journal-title":"Nutrients"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1330900","article-title":"Role of gut microbiota and bacterial translocation in acute intestinal injury and mortality in patients admitted in ICU for septic shock","volume":"13","author":"Magnan","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-3071-z","article-title":"A four-probiotics regimen reduces postoperative complications after colorectal surgery: A randomized, double-blind, placebo-controlled study","volume":"39","author":"Kotzampassi","year":"2015","journal-title":"World J Surg"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12050980","article-title":"Autoprobiotics in the treatment of patients with colorectal cancer in the early postoperative period","volume":"12","author":"Ermolenko","year":"2024","journal-title":"Microorganisms"},{"key":"B20","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/nutrit\/nuac069","article-title":"The effect of probiotics on postsurgical complications in patients with colorectal cancer: a systematic review and meta-analysis","volume":"81","author":"Araujo","year":"2023","journal-title":"Nutr Rev"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075001","article-title":"Microbial translocation across the GI tract","volume":"30","author":"Brenchley","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063204","article-title":"Preventing bacterial translocation in patients with leaky gut syndrome: nutrition and pharmacological treatment options","volume":"23","author":"Twardowska","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2024.100701","article-title":"Comprehensive insight into the alterations in the gut microbiome and the intestinal barrier as a consequence of iron deficiency anaemia","volume":"47","author":"Soriano-Lerma","year":"2024","journal-title":"BioMed J"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-017-1577-6","article-title":"Gut microbiota and bacterial translocation in digestive surgery: the impact of probiotics","volume":"402","author":"Komatsu","year":"2017","journal-title":"Langenbecks Arch Surg"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176402","article-title":"Gut microbiota and intestinal trans-epithelial permeability","volume":"21","author":"Allam-Ndoul","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147613","article-title":"Leaky gut: effect of dietary fiber and fats on microbiome and intestinal barrier","volume":"22","author":"Usuda","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.12.007","article-title":"Potentially modifiable determinants of malnutrition in older adults: A systematic review","volume":"38","author":"O'keeffe","year":"2019","journal-title":"Clin Nutr"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i31.5094","article-title":"Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets","volume":"19","author":"Jacobi","year":"2013","journal-title":"World J Gastroenterol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1192936","article-title":"Building better barriers: how nutrition and undernutrition impact pediatric intestinal health","volume":"14","author":"Andres","year":"2023","journal-title":"Front Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2024.02.001","article-title":"A new murine undernutrition model based on complementary feeding of undernourished children causes damage to the morphofunctional intestinal epithelium barrier","volume":"154","author":"Ribeiro","year":"2024","journal-title":"J Nutr"},{"key":"B32","doi-asserted-by":"publisher","first-page":"7635","DOI":"10.1038\/s41598-021-86920-w","article-title":"Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition","volume":"11","author":"Maghraby","year":"2021","journal-title":"Sci Rep"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa182","article-title":"The JAK inhibitor tofacitinib rescues intestinal barrier defects caused by disrupted epithelial-macrophage interactions","volume":"15","author":"Spalinger","year":"2021","journal-title":"J Crohns Colitis"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1444149\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T06:47:45Z","timestamp":1739774865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1444149\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":33,"alternative-id":["10.3389\/fonc.2025.1444149"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1444149","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,17]]},"article-number":"1444149"}}