{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:18:35Z","timestamp":1785151115052,"version":"3.55.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>With the development of various advanced radiotherapy techniques, research related to radiotherapy for bone metastases has made great progress, and scholars have published a large number of publications. In this study, we summarized the knowledge structure of radiotherapy for bone metastases and outlined the research hotspots through bibliometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Publications on radiotherapy for bone metastases from 1992 to 2024 were searched in the Web of Science Core Collection (WoSCC) database. Countries, institutions, authors, references, and keywords in the field were visualized using VOSviewer version 1.6.19 and CiteSpace version 6.3.R1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1303 publications from 71 countries were included in this study. The number of research publications on radiotherapy for bone metastases has been increasing year by year. The United States of America (USA) ranking first in terms of publication count and co-citation frequency. The most prolific institutions and authors were the University of Toronto and Sahgal A, while Chow E was the most co-cited author. The most co-cited paper was published by Lutz S et\u00a0al. in 2011 in Internation Journal Of Radiation Oncology Physics. \u201cstereotactic body radiotherapy\u201d, \u201cspine metastases\u201d, \u201cspinal cord compression\u201d, \u201c immunotherapy\u201d and \u201coligometastases\u201d are the main keywords of the current research topics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The application of stereotactic body radiotherapy (SBRT) in the treatment of patients with bone metastases, especially oligometastases, has attracted extensive attention from researchers. How to choose reasonable radiotherapy for patients with complicated bone metastases has now become a research hotspot. Radiotherapy combined with immunotherapy may be the future development trend.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1465104","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T04:11:15Z","timestamp":1756440675000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Global research trends in radiotherapy for bone metastases: a systematic bibliometric analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Fadong","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxiu","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianbin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjue","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Qiteng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41572-020-00216-3","article-title":"Bone metastases","volume":"61","author":"Coleman","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jbo.2014.10.003","article-title":"International patterns of practice in radiotherapy for bone metastases: A review of the literature","author":"McDonald","year":"2014","journal-title":"J Bone Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e000037","DOI":"10.1136\/esmoopen-2016-000037","article-title":"Diagnosis and treatment of bone metastasis: comprehensive guideline of the Japanese Society of Medical Oncology, Japanese Orthopedic Association","volume":"12","author":"Shibata","year":"2016","journal-title":"Japanese Urological Association Japanese Soc Radiat Oncology ESMO Open"},{"key":"B4","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3390\/cancers12030533","article-title":"A splice variant of NCOR2, BQ323636.1, confers chemoresistance in breast cancer by altering the activity of NRF2","volume":"12","author":"Leung","year":"2020","journal-title":"Cancers (Basel) 123"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3413\/Nukmed-0730-15-03","article-title":"The added value of SPECT\/spiral CT in patients with equivocal bony metastasis from hepatocellular carcinoma","volume":"546","author":"Zhang","year":"2015","journal-title":"Nuklearmedizin"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.5603\/RPOR.a2022.0009","article-title":"Stereotactic radiotherapy for bone oligometastases","volume":"271","author":"Colosimo","year":"2022","journal-title":"Rep Pract Oncol Radiother"},{"key":"B7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1967\/s002449910952","article-title":"More advantages in detecting bone and soft tissue metastases from prostate cancer using 18F-PSMA PET\/CT","volume":"221","author":"Pianou","year":"2019","journal-title":"Hell J Nucl Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-022-01383-x","article-title":"Global research trends in radiotherapy for breast cancer: a systematic bibliometric analysis","volume":"416","author":"Jia","year":"2023","journal-title":"Jpn J Radiol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3171\/2015.8.SPINE15674","article-title":"The 100 most-cited articles in spinal oncology","volume":"245","author":"l. 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