{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:19Z","timestamp":1753891879466,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Ovarian-type serous adenocarcinoma of the testis is an extremely rare malignant disease, and experience and evidence regarding its treatment are lacking. Herein, we describe the case of a 39-year-old man who presented with widespread metastasis in the retroperitoneal and pelvic lymph nodes after surgical resection of his right testicular tumor. Systemic chemotherapy with bevacizumab, the treatment strategy used for ovarian serous adenocarcinoma, was administered, and retroperitoneal lymph node dissection and radiotherapy followed after the lesions regressed. The patient has had over 3 years of progression-free survival. This is the first case of a bevacizumab combination in this disease and indicates that bevacizumab may be an option for the treatment strategy of this rare disease.<\/jats:p>","DOI":"10.3389\/fonc.2025.1467579","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T05:16:07Z","timestamp":1742534167000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: An ovarian epithelial-type serous adenocarcinoma of the testis was treated using systemic chemotherapy with bevacizumab, the treatment strategy used for ovarian serous carcinoma"],"prefix":"10.3389","volume":"15","author":[{"given":"Rui-Zhi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2017\/27743.10097","article-title":"High grade serous cystadenocarcinoma of testis-case report of a rare ovarian epithelial type tumour","volume":"11","author":"Aravind","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02017.x","article-title":"Papillary serous carcinoma of ovarian type of the testis with borderline differentiation","volume":"46","author":"Guarch","year":"2005","journal-title":"Histopathology."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1159\/000137653","article-title":"Ovarian type surface epithelial carcinoma of the testis with delayed metastatic spread","volume":"81","author":"Maruschke","year":"2008","journal-title":"Urol Int"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200309000-00005","article-title":"Primary mucinous tumors of the testis and paratestis: a report of nine cases","volume":"27","author":"Ulbright","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1159\/000327989","article-title":"Metastatic serous carcinoma of the testis: a case report and review of the literature","volume":"4","author":"Ma","year":"2011","journal-title":"Case Rep Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(00)80113-2","article-title":"Papillary serous carcinoma of the tunica vaginalis testis","volume":"196","author":"Becerra","year":"2000","journal-title":"Pathol Res Pract"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s13691-023-00608-8","article-title":"An unusual case of a tibial metastasis as the first clinical presentation of a serous papillary carcinoma of the ovarian epithelial type of the testis","volume":"12","author":"Napoletano","year":"2023","journal-title":"Int Cancer Conf J"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.18502\/jfrh.v13i2.1920","article-title":"A rare case of serous papillary ovarian epithelial type carcinoma in testis: A rare testicular neoplasm","volume":"13","author":"Abdollahi","year":"2019","journal-title":". 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