{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:25Z","timestamp":1753891825751,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>We report a case of a 60-year-old man who developed scattered erythema and papules on his left upper limb without any apparent cause 6 months ago. Initially, the patient underwent evaluations for various dermatological conditions, including eczema and psoriasis, while also being assessed for potential malignancies such as cutaneous lymphoma or sarcoidosis, but no definitive diagnosis was made. Over time, the patient\u2019s symptoms progressed, presenting as generalized erythema, papules, localized itching, and pain. A histopathological examination of the lesions diagnosed it as extranodal NK\/T-cell lymphoma, nasal type (ENKTCL-NT). Subsequently, the patient was referred for staging via 18F-fluorodeoxyglucose positron emission tomography\/computed tomography (<jats:sup>18<\/jats:sup>F-FDG PET\/CT), which revealed a widespread pattern of metabolically active lesions primarily affecting the skin and subcutaneous tissue of the limbs and buttocks. The patient received sequential treatment with P-GEMOX (gemcitabine, oxaliplatin, and pegaspargase) and underwent clinical examination and follow-up whole-body <jats:sup>18<\/jats:sup>F-FDG PET\/CT after six treatment cycles. The post-treatment PET\/CT showed no abnormal <jats:sup>18<\/jats:sup>F-FDG uptake in the nasal cavity or skin, confirming clinical complete remission. Our case highlights the significant role of <jats:sup>18<\/jats:sup>F-FDG PET\/CT in clinical practice for initial staging and treatment response assessment of ENKTCL-NT.<\/jats:p>","DOI":"10.3389\/fonc.2025.1480661","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T13:23:21Z","timestamp":1744377801000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["18F-FDG PET\/CT in the diagnosis and treatment of atypical extensive skin lesions in extranodal natural killer\/T-cell lymphoma, nasal type: a case report"],"prefix":"10.3389","volume":"15","author":[{"given":"Xu-Sheng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Jun","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01313-2","article-title":"NK-\/T-cell lymphomas","volume":"35","author":"Wang","year":"2021","journal-title":"Leukemia"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000004205","article-title":"Extranodal NK\/T-cell lymphoma with widespread cutaneous and subcutaneous involvement on 18F-FDG PET\/CT","volume":"47","author":"Filizoglu","year":"2022","journal-title":"Clin Nucl Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13045-022-01293-5","article-title":"How we treat NK\/T-cell lymphomas","volume":"15","author":"Tse","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103237","article-title":"Extranodal NK\/T cell lymphoma, nasal type: An updated overview","volume":"159","author":"S\u00e1nchez-Romero","year":"2021","journal-title":"Crit Rev Oncology\/Hematology"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1175545","article-title":"Extranodal NK-\/T-cell lymphoma, nasal type: what advances have been made in the last decade","volume":"13","author":"Costa","year":"2023","journal-title":"Front Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26335","article-title":"Sequential P-GEMOX and radiotherapy for early-stage extranodal natural killer\/T-cell lymphoma: A multicenter study","volume":"96","author":"Zhang","year":"2021","journal-title":"Am J 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natural killer\/T-cell lymphoma, nasal type: a case series","volume":"6","author":"MacDonald","year":"2011","journal-title":"Radiat Oncol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000004582","article-title":"FDG PET\/CT in a case of esophageal extranodal NK\/T-cell lymphoma, nasal type","volume":"48","author":"Zhang","year":"2023","journal-title":"Clin Nucl Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000004959","article-title":"Primary extranodal nasal-type natural killer\/T-cell lymphoma of lower limb muscles on 18 F-FDG PET\/CT","volume":"49","author":"Li","year":"2024","journal-title":"Clin Nucl Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000004756","article-title":"Nasal-type extranodal natural killer\/T-cell lymphoma recurrence at penile glans masquerading urinary contamination on 18 F-FDG PET\/CT","volume":"48","author":"Zhang","year":"2023","journal-title":"Clin Nucl 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