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In this paper, we review the expression and significance of TRPV1 receptor in various cancer cell types, the role of TRPV1 in the apoptosis-proliferation balance, cancer cell invasion and metastasis, and tumor micro-environment, with emphasis on the mechanisms by which TRPV1 receptor mediates inflammatory response, immune system, and thus regulates cancer. We discussed the latest directions and current challenges of TRPV1 receptor-targeting therapy for cancer, and summarized the odorous traditional herbs that modulate TRPV1 receptors, with a view to developing anti-tumor drugs targeting TRPV1 receptors in the future.<\/jats:p>","DOI":"10.3389\/fonc.2025.1488289","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T05:11:03Z","timestamp":1739250663000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal 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