{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:41:21Z","timestamp":1793720481471,"version":"4.6.1"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ovarian carcinoids are exceptionally rare. This report discusses an unprecedented case of a primary ovarian mixed insular and trabecular carcinoid, presenting with constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 47-year-old female presented with a four-month history of constipation. A comprehensive abdominal CT with contrast revealed a large mass in the pelvic region, measuring 8.6\u00d79.7\u00d79.3cm. Consequently, the patient was referred for further evaluation. Intraoperative exploration uncovered a 10.0\u00d79.0 cm mass in the left ovary. Initial histopathological assessment suggested a sex cord-stromal cell tumor, leading to a left ovariectomy and bilateral salpingectomy. Final histopathological analysis post-surgery identified the mass as a mixed insular and trabecular carcinoid. The patient was diagnosed with stage Ia, T1aN0M0 primary ovarian mixed insular and trabecular carcinoid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diagnosis of carcinoids predominantly relies on postoperative histopathological examination. As of now, There is no established standard treatment, emphasizing the necessity for ongoing patient monitoring.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1489978","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T05:22:17Z","timestamp":1738819337000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A rare case report of primary ovarian carcinoid presenting with constipation"],"prefix":"10.3389","volume":"15","author":[{"given":"Xiaofeng","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangfang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000129342.67174.67","article-title":"Updated population-based review of carcinoid tumors","volume":"240","author":"Maggard","year":"2004","journal-title":"Ann Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00399383","article-title":"Carcinoid tumors of the ovary","volume":"107","author":"Talerman","year":"1984","journal-title":"J Cancer Res Clin Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1600-4","article-title":"Primary ovarian trabecular carcinoid tumor: a case report and literature review","volume":"282","author":"Bai","year":"2010","journal-title":"Arch Gynecol Obstet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.10.015","article-title":"Primary insular carcinoid of the ovary","volume":"101","author":"Diaz-Montes","year":"2006","journal-title":"Gynecol Oncol"},{"key":"B5","article-title":"Primary neuroendocrine tumor of the testis: a study of clinicopathological features","volume":"7","author":"Han","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.871210","article-title":"Ovarian strumal carcinoid: case report, systematic literature review and pooled analysis","volume":"13","author":"Turla","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B7","article-title":"Peptide YY producing strumal carcinoid tumor of the ovary","volume":"32","author":"Matsunami","year":"2011","journal-title":"Eur J Gynaecol Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2018.01.002","article-title":"Aggressive neuroendocrine tumor of the ovary with multiple metastases treated with everolimus: A case report","volume":"23","author":"Kaiho-Sakuma","year":"2018","journal-title":"Gynecol Oncol Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.01.002","article-title":"Primary Malignant ovarian carcinoid; 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