{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:25:16Z","timestamp":1781108716414,"version":"3.54.1"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A growing body of evidence has demonstrated the expanding role of local treatment in managing colorectal cancer liver metastases (CRCLM). To identify current research trends and forecast future directions, we conducted a bibliometric analysis to examine global collaboration patterns and academic influence across countries, institutions, journals, and authors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Relevant articles and reviews on CRCLM local therapies were systematically retrieved from the Web of Science Core Collection. The bibliometric package in R software and VOSviewer software were used to analyze countries, institutions, journals, authors, and keywords. The research status and key areas of local treatment of colorectal cancer liver metastases were analyzed by keywords.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis encompassed 2,695 articles published between 2008 and 2023. The United States emerged as the leading contributor, with Memorial Sloan Kettering Cancer Center producing the highest number of publications (n=178). Among journals, <jats:italic>Annals of Surgical Oncology<\/jats:italic> ranked first in publication volume, while <jats:italic>Journal of Vascular and Interventional Radiology<\/jats:italic> achieved the highest citation count. The local treatment modalities for CRCLM included transarterial therapies (radioembolization and chemoembolization), hepatic artery infusion chemotherapy and immunotherapy, imaging guidance methods, hepatectomy and survival, and ablation and stereotactic body radiotherapy. Recent studies highlighted ablations, microspheres, and immunotherapy as key research areas, with thematic mapping identifying immunotherapy as an emerging niche field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRCLM local treatment research focuses on integrating local and systemic therapies. Preclinical studies, RFA with anti - PD - 1 agents, show enhanced anti - tumor immunity and survival. While the synergy of local and immunotherapy is confirmed, large - scale clinical evidence is still needed. Thus, cross - disciplinary cooperation is urgently required to boost translational medical research.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1490570","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T04:17:49Z","timestamp":1743481069000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Combining with immunotherapy is an emerging trend for local treatment of colorectal cancer liver metastases: a bibliometric analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Bin","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Shi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Nuo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou-Fa","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Zhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA: A Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.annonc.2022.10.003","article-title":"Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Cervantes","year":"2023","journal-title":"Ann Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.v109:4","article-title":"Survival after hepatic resection in metastatic colorectal cancer","volume":"109","author":"Cummings","year":"2007","journal-title":"Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000217629.94941.cf","article-title":"Epidemiology and management of liver metastases from colorectal cancer","volume":"244","author":"Manfredi","year":"2006","journal-title":"Ann Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1001\/jamanetworkopen.2022.36666","article-title":"Incidence and survival in synchronous and metachronous liver metastases from colorectal cancer","volume":"5","author":"Reboux","year":"2022","journal-title":"JAMA Netw Open"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.50299","article-title":"Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases: a population-based study","volume":"4","author":"V\u00e4yrynen","year":"2020","journal-title":"BJS Open"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw235","article-title":"ESMO consensus guidelines for the management of patients with metastatic colorectal cancer","volume":"27","author":"Van Cutsem","year":"2016","journal-title":"Ann Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.v117.17","article-title":"Stereotactic body radiotherapy for colorectal liver metastases: a pooled analysis","volume":"117","author":"Chang","year":"2011","journal-title":"Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.07.030","article-title":"Local control outcomes using stereotactic body radiation therapy for liver metastases from colorectal cancer","volume":"99","author":"Joo","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00818","article-title":"Stereotactic ablative radiotherapy for the comprehensive treatment of oligometastatic cancers: long-term results of the SABR-COMET phase II randomized trial","volume":"38","author":"Palma","year":"2020","journal-title":"J Clin Oncol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2017.1345629","article-title":"Liver-directed therapy in metastatic colorectal cancer","volume":"17","author":"Kelly","year":"2017","journal-title":"Expert Rev Anticancer Ther"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.46883\/2022.25920945","article-title":"Locoregional liver-directed therapies to treat unresectable colorectal liver metastases: A review","volume":"36","author":"McFadden","year":"2022","journal-title":"Oncol (Williston Park)"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2011.05.010","article-title":"Liver-directed therapies in colorectal cancer","volume":"38","author":"Alsina","year":"2011","journal-title":"Semin Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.0600","article-title":"Phase I study of individualized stereotactic body radiotherapy of liver metastases","volume":"27","author":"Lee","year":"2009","journal-title":"J Clin Oncol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/jso.v101:8","article-title":"Thermoablation of colorectal liver metastasis","volume":"101","author":"Kulaylat","year":"2010","journal-title":"J Surg Oncol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nrc3672","article-title":"Thermal ablation of tumours: biological mechanisms and advances in therapy","volume":"14","author":"Chu","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41573-018-0007-y","article-title":"Approaches to treat immune hot, altered and cold tumours with combination immunotherapies","volume":"18","author":"Galon","year":"2019","journal-title":"Nat Rev Drug Discovery"},{"key":"B18","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1148\/radiol.2511072175","article-title":"Radiofrequency ablation induces antigen-presenting cell infiltration and amplification of weak tumor-induced immunity","volume":"251","author":"Dromi","year":"2009","journal-title":"Radiology"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223994","article-title":"Visualizing a field of research: A methodology of systematic scientometric reviews","volume":"14","author":"Chen","year":"2019","journal-title":"PloS One"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.7659\/j.issn.1005-6947.2020.04.003","article-title":"Bibliometric analysis of publications in colorectal cancer liver metastasis from 2000 to 2019 based on Web of Science","volume":"29","author":"Shi","year":"2020","journal-title":"Chin J Gen Surge"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.7150\/jca.52842","article-title":"Evolutions of the management of colorectal cancer liver metastasis: A bibliometric analysis","volume":"12","author":"Jin","year":"2021","journal-title":"J Cancer"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.joi.2017.08.007","article-title":"bibliometrix: An R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J inform"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2174\/258997751102191111141801","article-title":"The H-index in life and health sciences: advantages, drawbacks and challenging opportunities","volume":"11","author":"Dinis-Oliveira","year":"2019","journal-title":"Curr Drug Res Rev"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.17_suppl.LBA3501","article-title":"Surgery versus thermal ablation for small-size colorectal liver metastases (COLLISION): An international, multicenter, phase III randomized controlled trial","volume":"42","author":"Meijerink","year":"2024","journal-title":"J Clin Oncol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds053","article-title":"Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC Intergroup phase II study (EORTC 40004)","volume":"23","author":"Ruers","year":"2012","journal-title":"Ann Oncol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/bjs.9649","article-title":"Long-term outcomes following microwave ablation for liver Malignancies","volume":"102","author":"Leung","year":"2015","journal-title":"Br J Surg"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2025-4","article-title":"Two decades of experience with hepatic cryotherapy for advanced colorectal metastases","volume":"19","author":"Ng","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1550342","DOI":"10.1080\/2162402X.2018.1550342","article-title":"Local immunomodulation combined to radiofrequency ablation results in a complete cure of local and distant colorectal carcinoma","volume":"8","author":"Lemdani","year":"2019","journal-title":"Oncoimmunology"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1352","article-title":"PD-1 blockade boosts radiofrequency ablation-elicited adaptive immune responses against tumor","volume":"22","author":"Shi","year":"2016","journal-title":"Clin Cancer Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1186\/s12967-022-03646-7","article-title":"LAG3 blockade coordinates with microwave ablation to promote CD8(+) T cell-mediated anti-tumor immunity","volume":"20","author":"Shao","year":"2022","journal-title":"J Transl Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/sj.bjc.6603341","article-title":"Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity","volume":"95","author":"den Brok","year":"2006","journal-title":"Br J Cancer"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.10.053","article-title":"Cryoablation induces greater inflammatory and coagulative responses than radiofrequency ablation or laser induced thermotherapy in a rat liver model","volume":"147","author":"Jansen","year":"2010","journal-title":"Surgery"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v9.i3.91","article-title":"Laser ablation of liver tumors: An ancillary technique, or an alternative to radiofrequency and microwave","volume":"9","author":"Sartori","year":"2017","journal-title":"World J Radiol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-016-1891-9","article-title":"Thermal and mechanical high-intensity focused ultrasound: perspectives on tumor ablation, immune effects and combination strategies","volume":"66","author":"van den Bijgaart","year":"2017","journal-title":"Cancer Immunol Immunother"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.811726","article-title":"Irreversible electroporation: an emerging immunomodulatory therapy on solid tumors","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cson.2023.100013","article-title":"Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastases (V. 2023)","volume":"2","author":"Ren","year":"2023","journal-title":"Clin Surg Oncol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6895","article-title":"Stereotactic body radiation therapy for colorectal liver metastases","volume":"97","author":"van der Pool","year":"2010","journal-title":"Br J Surg"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.06.035","article-title":"Stereotactic body radiotherapy for colorectal cancer liver metastases: A systematic review","volume":"129","author":"Petrelli","year":"2018","journal-title":"Radiother Oncol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s11888-021-00472-9","article-title":"The role of ablative radiotherapy to liver oligometastases from colorectal cancer","volume":"17","author":"Ku","year":"2021","journal-title":"Curr Colorect Cancer Rep"},{"key":"B41","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13045-020-00940-z","article-title":"SBRT combined with PD-1\/PD-L1 inhibitors in NSCLC treatment: a focus on the mechanisms, advances, and future challenges","volume":"13","author":"Chen","year":"2020","journal-title":"J Hematol Oncol"},{"key":"B42","article-title":"Intra-arterial infusion of irinotecan-loaded drug-eluting beads (DEBIRI) versus intravenous therapy (FOLFIRI) for hepatic metastases from colorectal cancer: final results of a phase III study","volume":"32","author":"Fiorentini","year":"2012","journal-title":"Anticancer Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-010-9996-6","article-title":"Intra-arterial hepatic chemotherapy: a comparison of percutaneous versus surgical implantation of port-catheters","volume":"34","author":"Deschamps","year":"2011","journal-title":"Cardiovasc Interv Radiol"},{"key":"B44","article-title":"Hepatic arterial chemotherapy in combination with systemic chemotherapy compared with hepatic arterial chemotherapy alone for liver metastases from colorectal cancer: results of a multi-centric randomized study","volume":"20","author":"Fiorentini","year":"2006","journal-title":"In Vivo"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2016.01.150","article-title":"Peripheral blood regulatory T-cell and type 1 helper T-cell population decrease after hepatic artery embolization","volume":"27","author":"Takaki","year":"2016","journal-title":"J Vasc Interv Radiol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jvir.2017.12.012","article-title":"Reply to: \u201cRe: immuno-oncology and its opportunities for interventional radiologists: immune checkpoint inhibition and potential synergies with interventional oncology procedures","volume":"29","author":"Hickey","year":"2018","journal-title":"J Vasc Interv Radiol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1007\/s00432-021-03708-1","article-title":"Treatment efficacy and safety of regorafenib plus drug-eluting beads-transarterial chemoembolization versus regorafenib monotherapy in colorectal cancer liver metastasis patients who fail standard treatment regimens","volume":"147","author":"Cao","year":"2021","journal-title":"J Cancer Res Clin Oncol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.e15563","article-title":"A retrospective study of local hepatic artery infusion chemotherapy combined with regorafenib in the treatment of advanced colorectal cancer with predominant liver metastases","volume":"39","author":"Cao","year":"2021","journal-title":"J Clin Oncol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2007.65","article-title":"Yttrium 90 microsphere selective internal radiation treatment of hepatic colorectal metastases","volume":"143","author":"Price","year":"2008","journal-title":"Arch Surg"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1080\/13651820410025084","article-title":"Selective internal radiation therapy (SIRT): a new modality for treating patients with colorectal liver metastases","volume":"6","author":"Stubbs","year":"2004","journal-title":"HPB (Oxford)"},{"key":"B51","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1634\/theoncologist.2019-0924","article-title":"A pilot feasibility study of yttrium-90 liver radioembolization followed by durvalumab and tremelimumab in patients with microsatellite stable colorectal cancer liver metastases","volume":"25","author":"Wang","year":"2020","journal-title":"Oncologist"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-019-0104-z","article-title":"HITM-SIR: phase Ib trial of intraarterial chimeric antigen receptor T-cell therapy and selective internal radiation therapy for CEA(+) liver metastases","volume":"27","author":"Katz","year":"2020","journal-title":"Cancer Gene Ther"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2022.0071","article-title":"Combining selective internal radiation therapy with immunotherapy in treating hepatocellular carcinoma and hepatic colorectal metastases: A systematic review","volume":"38","author":"Ramdhani","year":"2023","journal-title":"Cancer Biother Radiopharm"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v9.i3.91","article-title":"Microwave ablation (MWA): basics, technique and results in primary and metastatic liver neoplasms - review article","volume":"189","author":"Vogl","year":"2017","journal-title":"Rofo"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2017.08.004","article-title":"Functional hepatic imaging as a biomarker of primary and secondary tumor response to loco-regional therapies","volume":"26","author":"Lewis","year":"2017","journal-title":"Surg Oncol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100729","article-title":"Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and\/or FDG PET\/CT: a meta-analysis of prospective studies including patients who have not previously undergone treatment","volume":"257","author":"Niekel","year":"2010","journal-title":"Radiology"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.21037\/qims-20-173","article-title":"Combined with interventional therapy, immunotherapy can create a new outlook for tumor treatment","volume":"11","author":"Fang","year":"2021","journal-title":"Quant Imaging Med Surg"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1490570\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T04:17:56Z","timestamp":1743481076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1490570\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":57,"alternative-id":["10.3389\/fonc.2025.1490570"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1490570","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"article-number":"1490570"}}