{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:17:01Z","timestamp":1793236621002,"version":"4.5.0"},"reference-count":179,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Circulating tumor cells (CTCs) are cancerous cells that extravasate from the primary tumor or metastatic foci and travel through the bloodstream to distant organs. CTCs provide crucial insights into cancer metastasis, the evolution of tumor genotypes during treatment, and the development of chemo- and\/or radio-resistance during disease progression. The process of Epithelial-to-mesenchymal transition (EMT) plays a key role in CTCs formation, as this process enhances cell\u2019s migration properties and is often associated with increased invasiveness thereby leading to chemotherapy resistance. During the EMT process, tumor cells lose epithelial markers like EpCAM and acquire mesenchymal markers such as vimentin driven by transcription factors like Snail and Twist. CTCs are typically identified using specific cell surface markers, which vary depending on the cancer type. Common markers include EpCAM, used for epithelial cancers; CD44 and CD24, which are associated with cancer stem cells; and cytokeratins, such as CK8 and CK18. Other markers like HER2\/neu and vimentin can also be used to target CTCs in specific cancer types and stages. Commonly, immune-based isolation techniques are being implemented for the isolation and enrichment of CTCs. This review emphasizes the clinical relevance of CTCs, particularly in understanding drug resistance mechanisms, and underscores the importance of EMT-derived CTCs in multidrug resistance (MDR). Moreover, the review also discusses CTCs-specific surface markers that are crucial for their isolation and enrichment. Ultimately, the EMT-specific markers found in CTCs could provide significant information to halt the disease progression and enable personalized therapies.<\/jats:p>","DOI":"10.3389\/fonc.2025.1494723","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T01:26:48Z","timestamp":1743989208000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Circulating tumor cell markers for early detection and drug resistance assessment through liquid biopsy"],"prefix":"10.3389","volume":"15","author":[{"given":"Priya","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravanan","family":"Rajendrasozhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramzi Hadj","family":"Lajimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja Ramadevi","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Heymann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Rajendra","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"B1","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA: A Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/80051","article-title":"Cancer multidrug resistance","volume":"18","author":"Persidis","year":"2000","journal-title":"Nat Biotechnol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.3390\/ijms21093233","article-title":"Mechanisms of multidrug resistance in cancer chemotherapy","volume":"21","author":"Bukowski","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00267","article-title":"Drug resistance in non-small cell lung cancer: A potential for NOTCH targeting","volume":"8","author":"Sosa Iglesias","year":"2018","journal-title":"Front Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246246","article-title":"Mechanisms of drug resistance in ovarian cancer and associated gene targets","volume":"14","author":"Alatise","year":"2022","journal-title":"Cancers"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.3390\/ijms23063067","article-title":"Resistance mechanisms in pediatric B-cell acute lymphoblastic leukemia","volume":"23","author":"J\u0119draszek","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.3390\/cancers13153691","article-title":"Breast cancer drug resistance: overcoming the challenge by capitalizing on microRNA and tumor microenvironment interplay","volume":"13","author":"Cosentino","year":"2021","journal-title":"Cancers"},{"key":"B8","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12885-018-4076-4","article-title":"Factors associated with breast cancer recurrences or mortality and dynamic prediction of death using history of cancer recurrences: the French E3N cohort","volume":"18","author":"Lafourcade","year":"2018","journal-title":"BMC Cancer"},{"key":"B9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13073-019-0703-1","article-title":"Molecular profiling for precision cancer therapies","volume":"12","author":"Malone","year":"2020","journal-title":"Genome Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3390\/genes12030349","article-title":"Liquid biopsies: applications for cancer diagnosis and monitoring","volume":"12","author":"Martins","year":"2021","journal-title":"LID"},{"key":"B11","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3390\/jpm12030431","article-title":"Factors influencing on pain in patients undergoing pipelle endometrial biopsy for abnormal uterine bleeding: why a personalized approach should be applied","volume":"12","author":"Terzic","year":"2022","journal-title":"J Personalized Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2015.03.16","article-title":"Proposal of an appropriate decalcification method of bone marrow biopsy specimens in the era of expanding genetic molecular study","volume":"49","author":"Choi","year":"2015","journal-title":"J Pathol Trans Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s40121-017-0146-1","article-title":"Infections in cancer patients with solid tumors: A review","volume":"6","author":"Rolston","year":"2017","journal-title":"Infect Dis Ther"},{"key":"B14","doi-asserted-by":"publisher","first-page":"101759","DOI":"10.1016\/j.mex.2022.101759","article-title":"Biofluids manipulation methods for liquid biopsy in minimally-invasive assays","volume":"9","author":"Garzarelli","year":"2022","journal-title":"MethodsX"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.7150\/thno.34337","article-title":"Circulating tumor cells as a tool for assessing tumor heterogeneity","volume":"9","author":"Tellez-Gabriel","year":"2019","journal-title":"Theranostics"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.11.017","article-title":"Characterization of circulating tumor cells as a reflection of the tumor heterogeneity: myth or reality","volume":"24","author":"Brown","year":"2019","journal-title":"Drug Discovery Today"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.3390\/diagnostics11081391","article-title":"Liquid biopsy: A family of possible diagnostic tools","volume":"11","author":"Michela","year":"2021","journal-title":"Diagnostics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41392-021-00817-8","article-title":"Circulating tumor cells: biology and clinical significance","volume":"6","author":"Lin","year":"2021","journal-title":"Signal Transduction Targeted Ther"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3820","article-title":"Challenges in circulating tumour cell research","volume":"14","author":"Alix-Panabi\u00e8res","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-21-205","article-title":"Expression level of epithelial cell adhesion molecule (EpCAM) of circulating tumor cells (CTCs) of patients with NSCLC as an early indicator to monitor the effects of postoperative adjuvant chemotherapy","volume":"10","author":"Zhen","year":"2021","journal-title":"Trans Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.12.003","article-title":"Circulating tumor cells as a window on metastasis biology in lung cancer","volume":"178","author":"Hou","year":"2011","journal-title":"Am J Pathol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.02.007","article-title":"MUC1: a multifaceted oncoprotein with a key role in cancer progression","volume":"20","author":"Nath","year":"2014","journal-title":"Trends Mol Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174446","article-title":"HER2 expression in circulating tumour cells isolated from metastatic breast cancer patients using a size-based microfluidic device","volume":"13","author":"Lopes","year":"2021","journal-title":"Cancers"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050889","article-title":"Receptor tyrosine kinase ephB4 is a survival factor in breast cancer","volume":"169","author":"Kumar","year":"2006","journal-title":"Am J Pathol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020511","article-title":"N-cadherin mRNA levels in peripheral blood could be a potential indicator of new metastases in breast cancer: A pilot study","volume":"21","author":"Masuda","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e0217586","DOI":"10.1371\/journal.pone.0217586","article-title":"Clinical significance of glypican-3-positive circulating tumor cells of hepatocellular carcinoma patients: A prospective study","volume":"14","author":"Hamaoka","year":"2019","journal-title":"PloS One"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104971","article-title":"Trophoblast cell surface antigen-2 phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin","volume":"299","author":"Iwamoto","year":"2023","journal-title":"J Biol Chem"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e0226219","DOI":"10.1371\/journal.pone.0226219","article-title":"Prostate-specific membrane antigen in circulating tumor cells is a new poor prognostic marker for castration-resistant prostate cancer","volume":"15","author":"Nagaya","year":"2020","journal-title":"PloS One"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/cells13040337","article-title":"Extracellular vesicles, circulating tumor cells, and immune checkpoint inhibitors: hints and promises","volume":"13","author":"Bandini","year":"2024","journal-title":"Cells"},{"key":"B30","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40364-022-00403-2","article-title":"Detection of circulating tumor cells: opportunities and challenges","volume":"10","author":"Ju","year":"2022","journal-title":"biomark Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nature14347","article-title":"The evolutionary history of lethal metastatic prostate cancer","volume":"520","author":"Gundem","year":"2015","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"a000752","DOI":"10.1101\/mcs.a000752","article-title":"Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer","volume":"2","author":"Bova","year":"2016","journal-title":"Mol Case Stud"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0561-9","article-title":"Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers","volume":"25","author":"Parikh","year":"2019","journal-title":"Nat Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"12758","DOI":"10.1038\/s41598-024-63305-3","article-title":"Circulating tumor cells are a good predictor of tumor recurrence in clinical patients with gastric cancer","volume":"14","author":"Li","year":"2024","journal-title":"Sci Rep"},{"key":"B35","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s13045-019-0818-2","article-title":"Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy","volume":"12","author":"Lim","year":"2019","journal-title":"J Hematol Oncol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/s12951-022-01626-z","article-title":"Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer","volume":"20","author":"Yadav","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.652253","article-title":"Detection methods and clinical applications of circulating tumor cells in breast cancer","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Oncol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c05155","article-title":"Metabolism-based capture and analysis of circulating tumor cells in an open space","volume":"93","author":"Zhang","year":"2021","journal-title":"Analytical Chem"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/mi11080774","article-title":"Nanotechnology-assisted isolation and analysis of circulating tumor cells on microfluidic devices","volume":"11","author":"Cheng","year":"2020","journal-title":"Micromachines"},{"key":"B40","doi-asserted-by":"publisher","first-page":"100058","DOI":"10.1016\/j.cjac.2022.100058","article-title":"Isolation of circulating tumor cells based on magnetophoresis","volume":"50","author":"Xu","year":"2022","journal-title":"Chin J Analytical Chem"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123525","article-title":"Magnetic particles for CTC enrichment","volume":"12","author":"Liu","year":"2020","journal-title":"Cancers"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1038\/s41598-018-21068-8","article-title":"Gold nanoparticle-based rapid detection and isolation of cells using ligand-receptor chemistry","volume":"8","author":"Rauta","year":"2018","journal-title":"Sci Rep"},{"key":"B43","doi-asserted-by":"publisher","first-page":"80","DOI":"10.7150\/ntno.18216","article-title":"Gold nanoparticle based platforms for circulating cancer marker detection","volume":"1","author":"Huang","year":"2017","journal-title":"Nanotheranostics"},{"key":"B44","doi-asserted-by":"crossref","DOI":"10.1109\/EMBC46164.2021.9629506","article-title":"A graphene oxide-interfaced microfluidics system for isolating and capturing circulating tumor cells and microemboli","author":"Hsieh","year":"2021"},{"key":"B45","doi-asserted-by":"publisher","first-page":"100203","DOI":"10.1016\/j.ijoes.2023.100203","article-title":"Electrochemical detection and isolation of cancer cells using nano-materials based biosensors \u2013 A review","volume":"18","author":"Nagarajan","year":"2023","journal-title":"Int J Electrochem Sci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S187892","article-title":"Capture and biological release of circulating tumor cells in pancreatic cancer based on peptide-functionalized silicon nanowire substrate","volume":"14","author":"Shen","year":"2019","journal-title":"Int J Nanomed"},{"key":"B47","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12951-019-0466-2","article-title":"Random and aligned electrospun PLGA nanofibers embedded in microfluidic chips for cancer cell isolation and integration with air foam technology for cell release","volume":"17","author":"Yu","year":"2019","journal-title":"J Nanobiotechnol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.53.082901.103929","article-title":"Mechanisms of cancer drug resistance","volume":"53","author":"Gottesman","year":"2002","journal-title":"Annu Rev Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e1291","DOI":"10.1002\/cnr2.v5.12","article-title":"Molecular and cellular paradigms of multidrug resistance in cancer","volume":"5","author":"Vaidya","year":"2022","journal-title":"Cancer Rep"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092101","article-title":"The Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer","volume":"14","author":"Ye","year":"2022","journal-title":"Cancers"},{"key":"B51","doi-asserted-by":"publisher","first-page":"103537","DOI":"10.1016\/j.drudis.2023.103537","article-title":"ATP-binding cassette efflux transporters and MDR in cancer","volume":"28","author":"Pote","year":"2023","journal-title":"Drug Discovery Today"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.891652","article-title":"Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches","volume":"12","author":"Emran","year":"2022","journal-title":"Front Oncol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"113064","DOI":"10.1016\/j.biopha.2022.113064","article-title":"The multi-molecular mechanisms of tumor-targeted drug resistance in precision medicine","volume":"150","author":"Li","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e1009418","DOI":"10.1371\/journal.pcbi.1009418","article-title":"Drug-induced resistance evolution necessitates less aggressive treatment","volume":"17","author":"Kuosmanen","year":"2021","journal-title":"PloS Comput Biol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12885-016-2999-1","article-title":"Molecular chess? Hallmarks of anti-cancer drug resistance","volume":"17","author":"Cree","year":"2017","journal-title":"BMC Cancer"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2019.10","article-title":"Drug resistance and combating drug resistance in cancer","volume":"2","author":"Wang","year":"2019","journal-title":"Cancer Drug Resistance"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072653","article-title":"Circulating tumor cell clusters: united we stand divided we fall","volume":"21","author":"Amintas","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040684","article-title":"The role of circulating tumor cells in chemoresistant metastatic breast cancer","volume":"10","author":"Lisencu","year":"2021","journal-title":"J Clin Med"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2019.47","article-title":"Role of circulating tumor cell spheroids in drug resistance","volume":"2","author":"Hamilton","year":"2019","journal-title":"Cancer Drug Resistance"},{"key":"B60","doi-asserted-by":"publisher","first-page":"41707","DOI":"10.1038\/srep41707","article-title":"Microfluidic cell isolation technology for drug testing of single tumor cells and their clusters","volume":"7","author":"Bithi","year":"2017","journal-title":"Sci Rep"},{"key":"B61","doi-asserted-by":"publisher","first-page":"a036905","DOI":"10.1101\/cshperspect.a036905","article-title":"Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis","volume":"10","author":"Celi\u00e0-Terrassa","year":"2020","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"25","DOI":"10.21037\/sci.2019.08.08","article-title":"Epithelial-mesenchymal plasticity\u2014engaging stemness in an interplay of phenotypes","volume":"6","author":"Chin","year":"2019","journal-title":"Stem Cell Invest"},{"key":"B63","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12943-023-01748-4","article-title":"Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment","volume":"22","author":"Wu","year":"2023","journal-title":"Mol Cancer"},{"key":"B64","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/s41392-024-01938-6","article-title":"Circulating tumor cells: from new biological insights to clinical practice","volume":"9","author":"Gu","year":"2024","journal-title":"Signal Transduction Targeted Ther"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S38114","article-title":"Targeting cancer stem cells: emerging role of Nanog transcription factor","volume":"6","author":"Wang","year":"2013","journal-title":"OncoTargets Ther"},{"key":"B66","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/s41571-023-00815-5","article-title":"Drug-tolerant persister cells in cancer: the cutting edges and future directions","volume":"20","author":"Pu","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.11.004","article-title":"Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer","volume":"162","author":"Vallette","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.249706","article-title":"Circulating tumor cells: A review of non\u2013epCAM-based approaches for cell enrichment and isolation","volume":"62","author":"Gabriel","year":"2016","journal-title":"Clin Chem"},{"key":"B69","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13046-022-02263-y","article-title":"An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile","volume":"41","author":"De Angelis","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.04.049","article-title":"Stemness underpinning all steps of human colorectal cancer defines the core of effective therapeutic strategies","volume":"44","author":"Visioli","year":"2019","journal-title":"eBioMedicine"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1136\/gutjnl-2016-311447","article-title":"Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture","volume":"66","author":"Grillet","year":"2017","journal-title":"Gut"},{"key":"B72","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41416-020-01161-4","article-title":"The lingering mysteries of metastatic recurrence in breast cancer","volume":"124","author":"Riggio","year":"2021","journal-title":"Br J Cancer"},{"key":"B73","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41392-023-01725-9","article-title":"New insights into the correlations between circulating tumor cells and target organ metastasis","volume":"8","author":"Zhan","year":"2023","journal-title":"Signal Transduction Targeted Ther"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat Med"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3390\/cells12222590","article-title":"Circulating tumor cells as predictive and prognostic biomarkers in solid tumors","volume":"12","author":"Capuozzo","year":"2023","journal-title":"Cells"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.3390\/cancers16071377","article-title":"The role of circulating tumor cells as a liquid biopsy for cancer: advances, biology, technical challenges, and clinical relevance","volume":"16","author":"Allen","year":"2024","journal-title":"Cancers"},{"key":"B77","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41571-023-00781-y","article-title":"Circulating tumour cells for early detection of clinically relevant cancer","volume":"20","author":"Lawrence","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6546","article-title":"A collective route to metastasis: Seeding by tumor cell clusters","volume":"352","author":"Cheung","year":"2016","journal-title":"Science"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108105","article-title":"Hypoxia triggers the intravasation of clustered circulating tumor cells","volume":"32","author":"Donato","year":"2020","journal-title":"Cell Rep"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.07.013","article-title":"Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis","volume":"158","author":"Aceto","year":"2014","journal-title":"Cell"},{"key":"B81","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13073-020-00728-3","article-title":"Tracking cancer progression: from circulating tumor cells to metastasis","volume":"12","author":"Castro-Giner","year":"2020","journal-title":"Genome Med"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.3716","article-title":"Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer","volume":"30","author":"Hou","year":"2012","journal-title":"J Clin Oncol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1769","article-title":"Circulating tumor cells versus imaging\u2014Predicting overall survival in metastatic breast cancer","volume":"12","author":"Budd","year":"2006","journal-title":"Clin Cancer Res"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.7150\/thno.5195","article-title":"Detecting circulating tumor cells: current challenges and new trends","volume":"3","author":"Hong","year":"2013","journal-title":"Theranostics"},{"key":"B85","doi-asserted-by":"publisher","first-page":"e2437871","DOI":"10.1001\/jamanetworkopen.2024.37871","article-title":"Circulating tumor cell count and overall survival in patients with metastatic hormone-sensitive prostate cancer","volume":"7","author":"Goldkorn","year":"2024","journal-title":"JAMA Network Open"},{"key":"B86","doi-asserted-by":"publisher","first-page":"5372","DOI":"10.3390\/cancers15225372","article-title":"Recent progress in enhanced cancer diagnosis, prognosis, and monitoring using a combined analysis of the number of circulating tumor cells (CTCs) and other clinical parameters","volume":"15","author":"Nguyen","year":"2023","journal-title":"Cancers"},{"key":"B87","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41568-022-00536-4","article-title":"Biology, vulnerabilities and clinical applications of circulating tumour cells","volume":"23","author":"Ring","year":"2023","journal-title":"Nat Rev Cancer"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04875-y","article-title":"The metastatic spread of breast cancer accelerates during sleep","volume":"607","author":"Diamantopoulou","year":"2022","journal-title":"Nature"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112362","article-title":"ABC transporters in cancer stem cells: beyond chemoresistance","volume":"18","author":"Begicevic","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B90","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s12943-024-02087-8","article-title":"Induction of circulating ABCB1 transcripts under platinum-based chemotherapy indicates poor prognosis and a bone micrometastatic phenotype in ovarian cancer patients","volume":"23","author":"Schwarz","year":"2024","journal-title":"Mol Cancer"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-021-02112-3","article-title":"Acquired ABC-transporter overexpression in cancer cells: transcriptional induction or Darwinian selection","volume":"394","author":"Theile","year":"2021","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.02.038","article-title":"Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR","volume":"100","author":"Mohammad","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"B93","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.7150\/jca.19079","article-title":"Epithelial-mesenchymal transition: potential regulator of ABC transporters in tumor progression","volume":"8","author":"Jiang","year":"2017","journal-title":"J Cancer"},{"key":"B94","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3390\/cells9020428","article-title":"Epithelial to mesenchymal transition: A mechanism that fuels cancer radio\/chemoresistance","volume":"9","author":"Dud\u00e1s","year":"2020","journal-title":"Cells"},{"key":"B95","doi-asserted-by":"publisher","first-page":"100773","DOI":"10.1016\/j.tranon.2020.100773","article-title":"Epithelial-mesenchymal transition in cancer: A historical overview","volume":"13","author":"Ribatti","year":"2020","journal-title":"Trans Oncol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0529-5807.2014.04.006","article-title":"Expression of ABCG2 and p-glycoprotein in residual breast cancer tissue after chemotherapy and their correlation with epithelial-mesenchymal transition","volume":"43","author":"Qu","year":"2014","journal-title":"Chin J Pathol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01117.x","article-title":"Molecular markers in circulating tumour cells from metastatic colorectal cancer patients","volume":"14","author":"Gazzaniga","year":"2010","journal-title":"J Cell Mol Med"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23699","article-title":"Chemoresistance profile of circulating tumor cells: Toward a clinical benefit","volume":"123","author":"Gazzaniga","year":"2008","journal-title":"Int J Cancer"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.v126:10","article-title":"Chemosensitivity profile assay of circulating cancer cells: prognostic and predictive value in epithelial tumors","volume":"126","author":"Gazzaniga","year":"2010","journal-title":"Int J Cancer"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/nature19328","article-title":"HER2 expression identifies dynamic functional states within circulating breast cancer cells","volume":"537","author":"Jordan","year":"2016","journal-title":"Nature"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2004.n.014","article-title":"Monitoring the circulating levels of the HER2\/neu oncoprotein in breast cancer","volume":"5","author":"Carney","year":"2004","journal-title":"Clin Breast Cancer"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00381","article-title":"EMT and stemness in tumor dormancy and outgrowth: are they intertwined processes","volume":"8","author":"Weidenfeld","year":"2018","journal-title":"Front Oncol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.devcel.2018.05.027","article-title":"EMT subtype influences epithelial plasticity and mode of cell migration","volume":"45","author":"Aiello","year":"2018","journal-title":"Dev Cell"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-051222-122423","article-title":"Update on epithelial-mesenchymal plasticity in cancer progression","volume":"19","author":"Fontana","year":"2024","journal-title":"Annu Rev Pathol: Mech Dis"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.02.034","article-title":"Plasticity between epithelial and mesenchymal states unlinks EMT from metastasis-enhancing stem cell capacity","volume":"14","author":"Beerling","year":"2016","journal-title":"Cell Rep"},{"key":"B106","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s11033-020-06094-y","article-title":"Alternative splicing modulates cancer aggressiveness: role in EMT\/metastasis and chemoresistance","volume":"48","author":"Roy Burman","year":"2021","journal-title":"Mol Biol Rep"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nature15748","article-title":"Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance","volume":"527","author":"Fischer","year":"2015","journal-title":"Nature"},{"key":"B108","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13045-022-01280-w","article-title":"Single-cell sequencing: a promising approach for uncovering the mechanisms of tumor metastasis","volume":"15","author":"Han","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab0917","article-title":"RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance","volume":"349","author":"Miyamoto","year":"2015","journal-title":"Science"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320659110","article-title":"Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients","volume":"110","author":"Ni","year":"2013","journal-title":"Proc Natl Acad Sci"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-05-0506","article-title":"Snail and slug promote epithelial-mesenchymal transition through \u03b2-catenin\u2013T-cell factor-4-dependent expression of transforming growth factor-\u03b23","volume":"19","author":"Medici","year":"2008","journal-title":"Mol Biol Cell"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-00980-8","article-title":"Harnessing epithelial-mesenchymal plasticity to boost cancer immunotherapy","volume":"20","author":"Gu","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1002\/mol2.2017.11.issue-7","article-title":"New insights into the role of EMT in tumor immune escape","volume":"11","author":"Terry","year":"2017","journal-title":"Mol Oncol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3390\/diagnostics8030059","article-title":"The interplay between circulating tumor cells and the immune system: from immune escape to cancer immunotherapy","volume":"8","author":"Leone","year":"2018","journal-title":"Diagnostics"},{"key":"B115","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev-pathol-020117-043854","article-title":"Epithelial mesenchymal transition in tumor metastasis","volume":"13","author":"Mittal","year":"2018","journal-title":"Annu Rev Pathol: Mech Dis"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228522","article-title":"Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition","volume":"339","author":"Yu","year":"2013","journal-title":"Science"},{"key":"B117","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13058-016-0687-3","article-title":"In patients with metastatic breast cancer the identification of circulating tumor cells in epithelial-to-mesenchymal transition is associated with a poor prognosis","volume":"18","author":"Bulfoni","year":"2016","journal-title":"Breast Cancer Res"},{"key":"B118","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41392-023-01333-7","article-title":"Li Z-h: Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduction Targeted Ther"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2131","article-title":"Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype","volume":"7","author":"Peinado","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.v6i13","article-title":"EMT, CTCs and CSCs in tumor relapse and drug-resistance","volume":"6","author":"Mitra","year":"2015","journal-title":"Oncotarget"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000310","article-title":"Circulating tumor cells: strategies for capture, analyses, and propagation","volume":"24","author":"Agarwal","year":"2018","journal-title":"Cancer J (Sudbury Mass)"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12869","article-title":"Clinical utility of circulating tumor cells: an update","volume":"15","author":"Vasseur","year":"2021","journal-title":"Mol Oncol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081836","article-title":"Epithelial cell adhesion molecule: an anchor to isolate clinically relevant circulating tumor cells","volume":"9","author":"Eslami","year":"2020","journal-title":"Cells"},{"key":"B124","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1158\/1541-7786.MCR-10-0490","article-title":"Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers","volume":"9","author":"Armstrong","year":"2011","journal-title":"Mol Cancer Res"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.347","article-title":"Epithelial\u2013mesenchymal transition markers expressed in circulating tumor cells in hepatocellular carcinoma patients with different stages of disease","volume":"4","author":"Li","year":"2013","journal-title":"Cell Death Dis"},{"key":"B126","doi-asserted-by":"publisher","first-page":"2962580","DOI":"10.1155\/2019\/2962580","article-title":"Epithelial mesenchymal and endothelial mesenchymal transitions in hepatocellular carcinoma: A review","volume":"2019","author":"Gurzu","year":"2019","journal-title":"BioMed Res Int"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09898-3","article-title":"Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years","volume":"39","author":"Gires","year":"2020","journal-title":"Cancer Metastasis Rev"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052504","article-title":"Heterogeneous manifestations of epithelial\u2013mesenchymal plasticity of circulating tumor cells in breast cancer patients","volume":"22","author":"Tashireva","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.228122","article-title":"Circulating tumor cell enumeration with a combination of epithelial cell adhesion molecule\u2013 and cell-surface vimentin\u2013based methods for monitoring breast cancer therapeutic response","volume":"61","author":"Satelli","year":"2015","journal-title":"Clin Chem"},{"key":"B130","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s40364-021-00326-4","article-title":"Detection and clinical significance of circulating tumor cells in colorectal cancer","volume":"9","author":"Jiang","year":"2021","journal-title":"biomark Res"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.672195","article-title":"Early dissemination of circulating tumor cells: biological and clinical insights","volume":"11","author":"Chemi","year":"2021","journal-title":"Front Oncol"},{"key":"B132","doi-asserted-by":"crossref","DOI":"10.1200\/EDBK_158808","article-title":"Tumor heterogeneity and therapeutic resistance","volume-title":"American Society of Clinical Oncology Educational Book","author":"Lovly","year":"2016"},{"key":"B133","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrclinonc.2017.166","article-title":"Tumour heterogeneity and resistance to cancer therapies","volume":"15","author":"Dagogo-Jack","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.72534","article-title":"Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance","volume":"18","author":"Zhang","year":"2022","journal-title":"Int J Biol Sci"},{"key":"B135","first-page":"43","article-title":"Hypoxia-induced phenotypes that mediate tumor heterogeneity","volume-title":"Hypoxia and Cancer Metastasis","author":"Qian","year":"2019"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.165","article-title":"The significance of intertumor and intratumor heterogeneity in liver cancer","volume":"50","author":"Liu","year":"2018","journal-title":"Exp Mol Med"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw5473","article-title":"Metabolic reprogramming and cancer progression","volume":"368","author":"Faubert","year":"2020","journal-title":"Science"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818210116","article-title":"Cancer stemness, intratumoral heterogeneity, and immune response across cancers","volume":"116","author":"Miranda","year":"2019","journal-title":"Proc Natl Acad Sci"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.03.054","article-title":"Comparison between cells and cancer stem-like cells isolated from glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance\u2013associated protein genes","volume":"154","author":"Jin","year":"2008","journal-title":"Neuroscience"},{"key":"B140","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.1038\/s41467-021-24386-0","article-title":"Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma","volume":"12","author":"Sun","year":"2021","journal-title":"Nat Commun"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.509","article-title":"Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance","volume":"5","author":"Dahan","year":"2014","journal-title":"Cell Death Dis"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.v130.4","article-title":"Expression of epithelial\u2013mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy","volume":"130","author":"Mego","year":"2012","journal-title":"Int J Cancer"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0584","article-title":"Circulating tumor cells with stemness and epithelial-to-mesenchymal transition features are chemoresistant and predictive of poor outcome in metastatic breast cancer","volume":"18","author":"Papadaki","year":"2019","journal-title":"Mol Cancer Ther"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122574","article-title":"Drug resistance driven by cancer stem cells and their niche","volume":"18","author":"Prieto-Vila","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B145","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13045-022-01347-8","article-title":"The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis","volume":"15","author":"Huang","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B146","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/s41392-023-01383-x","article-title":"Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies","volume":"8","author":"Shi","year":"2023","journal-title":"Signal Transduction Targeted Ther"},{"key":"B147","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/mol2.2017.11.issue-7","article-title":"Revisiting epithelial-mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness","volume":"11","author":"Liao","year":"2017","journal-title":"Mol Oncol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17548","article-title":"Twist1 confers multidrug resistance in colon cancer through upregulation of ATP-binding cassette transporters","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1002\/stem.154","article-title":"Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells","volume":"27","author":"Kurrey","year":"2009","journal-title":"Stem Cells"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-020-01480-6","article-title":"TCF4 promotes colorectal cancer drug resistance and stemness via regulating ZEB1\/ZEB2 expression","volume":"257","author":"Sun","year":"2020","journal-title":"Protoplasma"},{"key":"B151","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1093\/annonc\/mdq323","article-title":"Circulating tumor cells (CTCs) in metastatic breast cancer (MBC): prognosis, drug resistance and phenotypic characterization","volume":"22","author":"Gradilone","year":"2011","journal-title":"Ann Oncol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"6993","DOI":"10.3390\/ijms22136993","article-title":"CD74 and CD44 expression on CTCs in cancer patients with brain metastasis","volume":"22","author":"Loreth","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.140","article-title":"Circulating tumor cells: A novel prognostic factor for newly diagnosed metastatic breast cancer","volume":"23","author":"Cristofanilli","year":"2005","journal-title":"J Clin Oncol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1593\/tlo.13367","article-title":"Mutational analysis of circulating tumor cells using a novel microfluidic collection device and qPCR assay","volume":"6","author":"Harb","year":"2013","journal-title":"Trans Oncol"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17271","article-title":"Molecular characterization of circulating tumor cells from patients with metastatic breast cancer reflects evolutionary changes in gene expression under the pressure of systemic therapy","volume":"8","author":"Aaltonen","year":"2017","journal-title":"Oncotarget"},{"key":"B156","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1186\/1471-2407-14-456","article-title":"Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow","volume":"14","author":"Deng","year":"2014","journal-title":"BMC Cancer"},{"key":"B157","first-page":"175","article-title":"Chapter six - markers of circulating breast cancer cells","volume-title":"Adv Clin Chem","author":"L\u00f3pez-Mu\u00f1oz","year":"2013"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.554554","article-title":"Preclinical and clinical evaluation of magnetic-activated cell separation technology for CTC isolation in breast cancer","volume":"10","author":"Lozar","year":"2020","journal-title":"Front Oncol"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.23687","article-title":"DEPArray\u2122 system: An automatic image-based sorter for isolation of pure circulating tumor cells","volume":"93","author":"Di Trapani","year":"2018","journal-title":"Cytometry Part A"},{"key":"B160","doi-asserted-by":"publisher","first-page":"26","DOI":"10.33393\/jcb.2023.2629","article-title":"Analytical performance of the FDA-cleared Parsortix\u00ae PC1 system","volume":"12","author":"Templeman","year":"2023","journal-title":"J Circulating Biomarkers"},{"key":"B161","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpj.2019.04.011","article-title":"Mechanics and actomyosin-dependent survival\/chemoresistance of suspended tumor cells in shear flow","volume":"116","author":"Xin","year":"2019","journal-title":"Biophys J"},{"key":"B162","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/cancers11010094","article-title":"Circulating tumor cells develop resistance to TRAIL-induced apoptosis through autophagic removal of death receptor 5: evidence from an in vitro model","volume":"11","author":"Twomey","year":"2019","journal-title":"Cancers"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.6_suppl.273","article-title":"Validation of nuclear-localized AR-V7 on circulating tumor cells (CTC) as a treatment-selection biomarker for managing metastatic castration-resistant prostate cancer (mCRPC)","volume":"4","author":"Scher","year":"2018","journal-title":"Am Soc Clin Oncol"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.v7i19","article-title":"Circulating tumor cells exhibit stem cell characteristics in an orthotopic mouse model of colorectal cancer","volume":"7","author":"Sch\u00f6lch","year":"2016","journal-title":"Oncotarget"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.652628","article-title":"Potentiated DNA damage response in circulating breast tumor cells confers resistance to chemotherapy","volume":"290","author":"Gong","year":"2015","journal-title":"J Biol Chem"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.06.012","article-title":"Circulating tumor cells exhibit a biologically aggressive cancer phenotype accompanied by selective resistance to chemotherapy","volume":"352","author":"Pavese","year":"2014","journal-title":"Cancer Lett"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28263","article-title":"CD133 expression in circulating tumor cells from breast cancer patients: Potential role in resistance to chemotherapy","volume":"133","author":"Nadal","year":"2013","journal-title":"Int J Cancer"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.5151","article-title":"Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with dukes\u2019 Stage B and C colorectal cancer","volume":"29","author":"Iinuma","year":"2011","journal-title":"J Clin Oncol"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0268","article-title":"Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor","volume":"13","author":"de Bono","year":"2007","journal-title":"Clin Cancer Res"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-1329","article-title":"Clinical significance of circulating tumor cells (CTCs) in hormone receptor-positive (HR+) metastatic breast cancer (MBC) patients (pts) receiving letrozole (Let) or Let plus bevacizumab (Bev): CALGB 40503 (Alliance)","volume":"37","author":"Magbanua","year":"2019","journal-title":"J Clin Oncol"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2561","article-title":"Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500","volume":"32","author":"Smerage","year":"2014","journal-title":"J Clin Oncol"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.2295","article-title":"Association of circulating tumor DNA and circulating tumor cells after neoadjuvant chemotherapy with disease recurrence in patients with triple-negative breast cancer: preplanned secondary analysis of the BRE12-158 randomized clinical trial","volume":"6","author":"Radovich","year":"2020","journal-title":"JAMA Oncol"},{"key":"B173","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/s41523-021-00319-4","article-title":"Multimodal liquid biopsy for early monitoring and outcome prediction of chemotherapy in metastatic breast cancer","volume":"7","author":"Bortolini Silveira","year":"2021","journal-title":"NPJ Breast Cancer"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaa113","article-title":"Serial analysis of circulating tumor cells in metastatic breast cancer receiving first-line chemotherapy","volume":"113","author":"Magbanua","year":"2021","journal-title":"JNCI: J Natl Cancer Institute"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1913","article-title":"Development of circulating tumor cell-endocrine therapy index in patients with hormone receptor\u2013positive breast cancer","volume":"21","author":"Paoletti","year":"2015","journal-title":"Clin Cancer Res"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2020.02.014","article-title":"Association between baseline circulating tumor cells, molecular tumor profiling, and clinical characteristics in a large cohort of chemo-naive metastatic colorectal cancer patients prospectively collected","volume":"19","author":"Sastre","year":"2020","journal-title":"Clin Colorectal Cancer"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060516","article-title":"Circulating tumor cells and circulating tumor DNA detection in potentially resectable metastatic colorectal cancer: A prospective ancillary study to the unicancer prodige-14 trial","volume":"8","author":"Bidard","year":"2019","journal-title":"Cells"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003035","article-title":"Circulating tumor cells are an independent predictor of shorter survival in patients undergoing resection for pancreatic and periampullary adenocarcinoma","volume":"271","author":"Hugenschmidt","year":"2020","journal-title":"Ann Surg"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00169","article-title":"Prospective evaluation of clinical outcomes using a multiplex liquid biopsy targeting diverse resistance mechanisms in metastatic prostate cancer","volume":"39","author":"Sperger","year":"2021","journal-title":"J Clin Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1494723\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T01:27:09Z","timestamp":1743989229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1494723\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":179,"alternative-id":["10.3389\/fonc.2025.1494723"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1494723","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"article-number":"1494723"}}