{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:31Z","timestamp":1753891831867,"version":"3.41.2"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Primary small cell carcinoma of the ovary is an extremely rare and highly malignant ovarian malignancy. The tissue origin of this type of cancer is still unclear, and it is characterized by rapid progression and a discouraging prognosis. The clinical presentation of small cell carcinoma of the ovary lacks specificity, and there are currently no effective treatment options available. Therefore, it is crucial to improve the understanding and identification of this disease. In this paper, we present a case of composite small cell carcinoma of the ovary with mucinous adenocarcinoma and provide a comprehensive review of the relevant literature.<\/jats:p>","DOI":"10.3389\/fonc.2025.1500088","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:11:02Z","timestamp":1740460262000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Compound cancer with small cell carcinoma and mucinous adenocarcinoma of the ovary: a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Wan","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genhua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buzhen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199604000-00012","article-title":"Neuroendocrine carcinoma arising in an ovarian mucinous cystadenoma","volume":"15","author":"Jones","year":"1996","journal-title":"Int J Gynecol Pathol: Off J Int Soc Gynecol Pathol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02390091","article-title":"Primary mixed neuroendocrine and mucinous carcinoma of the ovary","volume":"248","author":"Collins","year":"1991","journal-title":"Arch Gynecol Obstet"},{"key":"B4","article-title":"Ovarian neuroendocrine carcinoma associated with a mucinous neoplasm","volume":"118","author":"Khurana","year":"1994","journal-title":"Arch Pathol Lab Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b013e318039373a","article-title":"Small cell carcinoma of pulmonary type inside a microinvasive mucinous cystadenocarcinoma of the ovary: a case report","volume":"26","author":"Grandjean","year":"2007","journal-title":"Int J Gynecol Pathol: Off J Int Soc Gynecol Pathol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0529-5807.2018.05.015","article-title":"mucinous cystadenocarcinoma of ovary associated with neuroendocrine carcinoma (primary ovarian pulmonary-type small cell carcinoma): report of a case","volume":"47","author":"Qu","year":"2018","journal-title":"Zhonghua Bing Li Xue Za Zhi = Chin J Pathol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b013e318039373a","article-title":"Small-cell carcinoma-associated ovarian mucinous carcinoma: a case report and literature review","volume":"215","author":"Wei","year":"2019","journal-title":"Pathol Res Pract"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.19468","article-title":"A rare presentation of dual ovarian pathologies: small cell carcinoma of the ovary and mucinous ovarian cancer","volume":"13","author":"Mannan","year":"2021","journal-title":"Cureus"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0529-5807.2014.10.001","article-title":"introduction of WHO classification of tumours of female reproductive organs, fourth edition","volume":"43","author":"Lu","year":"2014","journal-title":"Zhonghua Bing Li Xue Za Zhi = Chin J Pathol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/his.14609","article-title":"Key changes to the world health organization (WHO) classification of female genital tumours introduced in the 5th edition (2020)","volume":"80","author":"McCluggage","year":"2022","journal-title":"Histopathology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199411000-00004","article-title":"Small cell carcinoma of the ovary, hypercalcemic type. 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