{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:58:41Z","timestamp":1784735921014,"version":"3.55.0"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>While there have been prior reports on pulmonary nodule (PN) localization through computed tomography (CT)-guided soft hook-wire (SHW) placement, there remains a dearth of studies specifically focused on the CT-guided SHW localization of multiple PNs. This study was thus designed to specifically evaluate the efficacy and safety of this localization strategy in patients with multiple PNs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 43 consecutive patients with multiple PNs underwent CT-guided SHW localization followed by video-assisted thoracoscopic surgery (VATS) to resent these PNs in our hospital between January 2022 and December 2022. A control group consisting of 140 individuals who underwent the CT-guided SHW localization of a single PN during the same interval was also selected. Both groups were analyzed retrospectively for safety and efficacy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final study population included 43 patients (94 PNs) in the multiple PN group, and 140 patients (140 PNs) in the single PN group, with all patients having undergone CT-guided SHW localization of these PNs. A one-stage procedure was employed for the localization of multiple PNs. The respective rates of technical success for SHW localization in the multiple and single PN groups were 98.9% and 100% (P = 0.402). The duration of localization in the multiple PN group was significantly longer than that in the single PN group (P = 0.001). The respective pneumothorax rates in the multiple and single PN groups were 32.5% (14\/43) and 15.7% (22\/140) (P = 0.015), while the corresponding lung hemorrhage incidence rates were 48.8% (21\/43) and 36.4% (51\/140) (P = 0.145). All PNs successfully underwent limited VATS resection, with a one-stage VATS procedure having been used for the resection of multiple PNs in a given patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CT-guided SHW localization is a safe and effective means of localizing multiple PNs in a single patient. This simultaneous localization of multiple PNs can provide effective guidance for the subsequent one-stage limited VATS resection of these nodules.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1501165","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:18:06Z","timestamp":1740133086000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Preoperative computed tomography-guided soft hook-wire localization for multiple pulmonary nodules"],"prefix":"10.3389","volume":"15","author":[{"given":"Guang-Chao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Long","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Bing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle","year":"2011","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209120","article-title":"Results of initial low-dose computed tomographic screening for lung cancer","volume":"368","author":"Church","year":"2013","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1363455","article-title":"Lung cancer screening: the radiologist\u2019s perspective","volume":"35","author":"Prokop","year":"2014","journal-title":"Semin Respir Crit Care Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017161659","article-title":"Guidelines for management of incidental pulmonary nodules detected on CT images: from the fleischner society 2017","volume":"284","author":"MacMahon","year":"2017","journal-title":"Radiology"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000001071","article-title":"Computed tomography-guided biopsy for small (\u226420 mm) lung nodules: A meta-analysis","volume":"44","author":"Liu","year":"2020","journal-title":"J Comput Assist Tomogr"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2017.0484","article-title":"Coil localization-guided video-assisted thoracoscopic surgery for lung nodules","volume":"28","author":"Fu","year":"2018","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1708836","article-title":"Methylene blue versus coil-based computed tomography-guided localization of lung nodules","volume":"68","author":"Zhang","year":"2020","journal-title":"Thorac Cardiovasc Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1682.e1","DOI":"10.1016\/j.jvir.2020.04.028","article-title":"Methylene blue\/collagen mixture for CT-guided presurgical lung nodule marking: high efficacy and safety","volume":"31","author":"Aoun","year":"2020","journal-title":"J Vasc Interv Radiol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2022.116396","article-title":"Comparison between coil and hook-wire localization before video-assisted thoracoscopic surgery for lung nodules: a systematic review and meta-analysis","volume":"17","author":"Wang","year":"2022","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.37766\/inplasy2023.5.0082","article-title":"Comparison between preoperative hook-wire and liquid material localization for pulmonary nodules: a meta-analysis","volume":"18","author":"Wang","year":"2023","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2023.130330","article-title":"Computed tomography guided hook-wire precise localization and minimally invasive resection of pulmonary nodules","volume":"18","author":"Wang","year":"2015","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"B12","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13019-019-0870-6","article-title":"Computed tomography-guided simultaneous coil localization as a bridge to one-stage surgery for multiple lung nodules: a retrospective study","volume":"14","author":"Fu","year":"2019","journal-title":"J Cardiothorac Surg"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2021.104199","article-title":"Computed tomography-guided localization for multiple pulmonary nodules: a meta-analysis","volume":"16","author":"Tang","year":"2021","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/jso.v118.7","article-title":"Modified hook-wire placement technique for localizing multiple pulmonary nodules","volume":"118","author":"Kadeer","year":"2018","journal-title":"J Surg Oncol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1080\/13645706.2022.2034647","article-title":"Preoperative computed tomography-guided localization for lung nodules: localization needle versus coil","volume":"31","author":"Huang","year":"2022","journal-title":"Minim Invasive Ther Allied Technol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2023.134158","article-title":"Preoperative computed tomography-guided localization for pulmonary nodules: comparison between hook-wire and anchored needle localization","volume":"19","author":"Zhou","year":"2024","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08101-7","article-title":"Computed tomography-guided cyanoacrylate injection for localization of multiple ipsilateral lung nodules","volume":"32","author":"Xu","year":"2022","journal-title":"Eur Radiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2023.124272","article-title":"Computed tomography-guided indocyanine green localization of multiple ipsilateral lung nodules","volume":"18","author":"Lin","year":"2023","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2021.105683","article-title":"Computed tomography-guided simultaneous coil localization of multiple pulmonary nodules before video-assisted thoracoscopic surgery","volume":"17","author":"Ai","year":"2022","journal-title":"Wideochir Inne Tech Maloinwazyjne"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1501165\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:18:08Z","timestamp":1740133088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1501165\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":19,"alternative-id":["10.3389\/fonc.2025.1501165"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1501165","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,21]]},"article-number":"1501165"}}