{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:28:28Z","timestamp":1780068508088,"version":"3.54.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study assesses the clinical utility of contrast - enhanced ultrasound (CEUS) in comparison to contrast - enhanced computed tomography (CECT) in the context of peripheral lung mass biopsy. The overarching objective is to establish robust clinical benchmarks that can guide evidence - based decision - making in the field of pulmonary interventional procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comparison of 420 patients admitted to our hospital from January 2019 to December 2022 who underwent biopsy using two different guidance methods, including 196 cases in the CEUS-guided biopsy group and 224 cases in the CECT-guided biopsy group. The average number of pleural punctures, puncture time, satisfaction with the first puncture specimen, diagnostic accuracy and complication rate were compared between the two guidance methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u2460 Compared with the CECT group, the CEUS-guided group required fewer pleural punctures (2.5 vs. 4.1 times) and shorter puncture time (24 minutes vs. 42 minutes) on average, and the difference was statistically significant (P&amp;lt;0.001). \u2461 In terms of complications, the incidence of pneumothorax (3.1% vs. 8%) was lower in the CEUS group, while the incidence of bleeding (1.5% vs. 3.1%) had no significant difference between the two groups \u2462 When the diameter of the lesion is &amp;lt;3 cm, the specimen satisfaction and diagnostic accuracy of the CEUS group are lower than those of the CECT group (71.0% vs. 88.3%, 64.5% vs. 86.7%). When the diameter of the lesion is (3 ~ 6cm), the specimen satisfaction and diagnostic accuracy of the CEUS group were higher than those of the CECT group (98.6% vs. 89.6%, 95.8% vs. 85.2%), and the above differences were statistically significant; but when the diameter of the lesion was &amp;gt;6cm, there was no significant difference in specimen satisfaction rate and diagnostic accuracy between the two guidance methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CEUS is better than CECT in reducing the number of punctures, shortening puncture time and reducing the incidence of pneumothorax, and is especially suitable for the diagnosis of medium-sized lesions. However, for lesions less than 3 cm in diameter, CECT demonstrated higher specimen satisfaction and diagnostic accuracy. This suggests that diagnostic performance can be optimized by selecting appropriate guidance techniques based on lesion size and risk of complications.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1502356","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:13:42Z","timestamp":1745986422000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of the application value of contrast-enhanced ultrasound and contrast-enhanced CT in puncture biopsy of peripheral pulmonary 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