{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:40Z","timestamp":1753891840213,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Calcifying fibrous tumor (CFT) is an uncommon benign fibrous neoplastic lesion that may manifest as singular or multiple tumors and usually occurs in children or young adults. CFT originates in the muscularis propria of the stomach and is a very rare disease. Here, we report a case of gastric CFT with upper gastrointestinal bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case information<\/jats:title><jats:p>A 39-year-old male was urgently referred to our hospital with haematemesis and melena that had developed over the course of 2 hours. Enhanced abdominal CT imaging revealed a nodular lesion, measuring approximately 3.2 \u00d7 2.1 \u00d7 1.6 cm, protruding from the posterior wall of the gastric body into the gastric lumen. The lesion exhibited scattered calcifications, smooth margins, and a CT attenuation value of 50 Hounsfield units (HU). Gastroscopic ultrasonography performed in the gastroenterology department revealed a semicircular submucosal mass with signs of active bleeding. Initially, the tumor was diagnosed as a gastrointestinal stromal tumor (GIST), and surgical intervention was undertaken due to ongoing hemorrhage. Postoperative histopathological examination confirmed the diagnosis of a gastric calcifying fibrous tumor (CFT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CFT originating from the muscularis propria of the stomach is exceptionally rare, and the case presented here mimicked a gastric submucosal tumor (SMTs),clinicians should consider this differentia diagnosis when evaluating patients with suspected cases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2025.1512964","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T04:11:14Z","timestamp":1745813474000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcifying fibrous tumor of stomach: a rare case report of an upper gastrointestinal bleeding"],"prefix":"10.3389","volume":"15","author":[{"given":"BaoLong","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZiWen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JunFeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KeXing","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CaiLiang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003690","article-title":"Calcifying fibrous tumor: review of 157 patients reported in international literature","volume":"95","author":"Chorti","year":"2016","journal-title":"Med (Baltimore)"},{"key":"B2","first-page":"798","article-title":"Childhood fibrous tumor with psammomabodies. Clinicopathologic features in two cases","volume":"112","author":"Rosenthal","year":"1988","journal-title":"Arch Pathol Lab Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199305000-00010","article-title":"Calcifying fibrous pseudotumor","volume":"17","author":"Fetsch","year":"1993","journal-title":"Am J Surg Pathol"},{"year":"","key":"B4","article-title":"WHO Classification of Tumours Editorial Board. WHO Classification of Tumours Soft Tissue and Bone Tumours, 5th ed. Lyon: IARC Press (2020)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ccb172","article-title":"Calcifying fibrous tumor of the stomach:clinicopathologic and molecular study of seven cases with literature review and reappraisal of histogenesis","volume":"34","author":"Agaimy","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i37.5597","article-title":"Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update","volume":"26","author":"Turbiville","year":"2020","journal-title":"World J Gastroenterol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.humpath.2017.01.002","article-title":"Clinicopathologic study of calcifying fibrous tumor of the gastrointestinal tract:a case series","volume":"62","author":"Pezhouh","year":"2017","journal-title":"Hum Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213307.05811.f0","article-title":"Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations","volume":"31","author":"Agaimy","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/iep.12339","article-title":"Calcifying fibrous tumour: An IgG4-related disease or not","volume":"101","author":"Hu","year":"2020","journal-title":"Int J Exp Pathol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02456.x","article-title":"Sclerosing angiomatoid nodular transformation of the spleen (SANT): clinicopathological study of 10 cases with or without abdominal disseminated calcifying fibrous tumors, and the presence of a significant number of IgG4+ plasma cells","volume":"59","author":"Kuo","year":"2009","journal-title":"Pathol Int"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199903000-00013","article-title":"Is calcifying fibrous pseudotumor a late sclerosing stage of inflammatory myofibroblastic tumor","volume":"23","author":"Van Dorpe","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4103\/JLP.JLP_16_19","article-title":"Castleman\u2019s disease associated with calcifying fibrous tumor: A rare association with review of literature","volume":"11","author":"Marbaniang","year":"2019","journal-title":"J Lab Physicians"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880390","article-title":"Calcifying fibrous pseudotumor versus inflammatory myofibroblastic tumor: a histological and immunohistochemical comparison","volume":"14","author":"Hill","year":"2001","journal-title":"Mod Pathol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v5.i9.457","article-title":"Gastric calcifying fibrous tumor removed by endoscopic submucosal dissection","volume":"5","author":"Ogasawara","year":"2013","journal-title":"World J Gastrointest Endosc"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-28","article-title":"Calcifying fibrous tumor presenting as rectal submucosal tumor: first case reported in rectum","volume":"12","author":"Im","year":"2014","journal-title":"World J Surg Oncol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/26883993","article-title":"Gastric calcifying fibrous pseudotumour associated with an ulcer: report of one case with a literature review","volume":"83","author":"Fan","year":"2010","journal-title":"Br J Radiol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1512964\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T04:11:15Z","timestamp":1745813475000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2025.1512964\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":16,"alternative-id":["10.3389\/fonc.2025.1512964"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2025.1512964","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2025,4,28]]},"article-number":"1512964"}}